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Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development

Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalat...

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Main Author: Nur Qistina Diyana, binti Khairul Anwar
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2016
Subjects:
QD Chemistry
Online Access:http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf
http://ir.unimas.my/id/eprint/15471/
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spelling my.unimas.ir.154712024-02-09T07:28:19Z http://ir.unimas.my/id/eprint/15471/ Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development Nur Qistina Diyana, binti Khairul Anwar QD Chemistry Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalate family. In this study, the effects of dipropyl phthalate on the development of zebrafish embryos and early larval stages were investigated. Eggs were exposed to dipropyl phthalate toxic started from 4 to 96-hour post fertilization (hpf), and defects of the zebrafish larvae examined at 96 hpf. Toxicological endpoints like mortality, hatching delay, pericardial edema, yolk sac edema, non-inflated swim bladder, deformation of the tail, blood island, and mobility were recorded. The LC5o calculated to be 7.546 mg/L. These results suggest that dipropyl phthalate could induce a dose-dependent toxicity in embryos, which hinders normal development. Universiti Malaysia Sarawak, (UNIMAS) 2016 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf Nur Qistina Diyana, binti Khairul Anwar (2016) Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Nur Qistina Diyana, binti Khairul Anwar
Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
description Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalate family. In this study, the effects of dipropyl phthalate on the development of zebrafish embryos and early larval stages were investigated. Eggs were exposed to dipropyl phthalate toxic started from 4 to 96-hour post fertilization (hpf), and defects of the zebrafish larvae examined at 96 hpf. Toxicological endpoints like mortality, hatching delay, pericardial edema, yolk sac edema, non-inflated swim bladder, deformation of the tail, blood island, and mobility were recorded. The LC5o calculated to be 7.546 mg/L. These results suggest that dipropyl phthalate could induce a dose-dependent toxicity in embryos, which hinders normal development.
format Final Year Project Report
author Nur Qistina Diyana, binti Khairul Anwar
author_facet Nur Qistina Diyana, binti Khairul Anwar
author_sort Nur Qistina Diyana, binti Khairul Anwar
title Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
title_short Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
title_full Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
title_fullStr Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
title_full_unstemmed Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
title_sort toxicity screening analysis of dipropyl phthalate, dpp on early vertebrate development
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2016
url http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf
http://ir.unimas.my/id/eprint/15471/
_version_ 1792160592519233536
score 13.211869

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