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Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones

A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Rea...

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Main Authors: Syed Salman, Shafqat, Amir Azam, Khan, Misbahulain, Khan, Kuan, Nicholas Hoo Tien, Mohd Syahmi, Jamaludin, Pang, Suh Cem
Format: Article
Language:English
Published: EDP Sciences 2016
Subjects:
TJ Mechanical engineering and machinery
Online Access:http://ir.unimas.my/id/eprint/15184/1/Syed.pdf
http://ir.unimas.my/id/eprint/15184/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009080515&doi=10.1051%2fmatecconf%2f20178702025&partnerID=40&md5=86554cb141737de40bb0d27e2a6d1e03
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spelling my.unimas.ir.151842021-06-09T14:59:26Z http://ir.unimas.my/id/eprint/15184/ Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones Syed Salman, Shafqat Amir Azam, Khan Misbahulain, Khan Kuan, Nicholas Hoo Tien Mohd Syahmi, Jamaludin Pang, Suh Cem TJ Mechanical engineering and machinery A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character EDP Sciences 2016-12-12 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15184/1/Syed.pdf Syed Salman, Shafqat and Amir Azam, Khan and Misbahulain, Khan and Kuan, Nicholas Hoo Tien and Mohd Syahmi, Jamaludin and Pang, Suh Cem (2016) Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones. MATEC Web of Conferences, 87. ISSN 2261236X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009080515&doi=10.1051%2fmatecconf%2f20178702025&partnerID=40&md5=86554cb141737de40bb0d27e2a6d1e03 DOI: 10.1051/matecconf/20178702025
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Syed Salman, Shafqat
Amir Azam, Khan
Misbahulain, Khan
Kuan, Nicholas Hoo Tien
Mohd Syahmi, Jamaludin
Pang, Suh Cem
Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
description A general, simple, efficient, cost-effective and environmental benign procedure for the syntheses of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones (DHPMs) has been developed. The reaction is efficiently catalysed by using various amino acids viz., glycine, L-proline, L-cysteine, leucine and tryptophan. Reactions give excellent yields under reflux conditions. The chemical structures of these compounds were identified by Fourier Transform-Infra Red Spectroscopy (FT-IR), Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H NMR). Physical parameters such as m.p., mixed m.p. as well as TLC also helped to characterize the expected products. The progress of the reaction time and purity was checked by TLC and the products were purified by recrystallization using ethyl acetate as a solvent. The synthesized molecule has numerous biological applications as it is anti-microbial, anti-inflammatory and anti-hypertensive in character
format Article
author Syed Salman, Shafqat
Amir Azam, Khan
Misbahulain, Khan
Kuan, Nicholas Hoo Tien
Mohd Syahmi, Jamaludin
Pang, Suh Cem
author_facet Syed Salman, Shafqat
Amir Azam, Khan
Misbahulain, Khan
Kuan, Nicholas Hoo Tien
Mohd Syahmi, Jamaludin
Pang, Suh Cem
author_sort Syed Salman, Shafqat
title Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
title_short Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
title_full Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
title_fullStr Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
title_full_unstemmed Environmentally Benign Syntheses and Characterization of 4- Aryldihydropyrimidin-2(1H)-ones
title_sort environmentally benign syntheses and characterization of 4- aryldihydropyrimidin-2(1h)-ones
publisher EDP Sciences
publishDate 2016
url http://ir.unimas.my/id/eprint/15184/1/Syed.pdf
http://ir.unimas.my/id/eprint/15184/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009080515&doi=10.1051%2fmatecconf%2f20178702025&partnerID=40&md5=86554cb141737de40bb0d27e2a6d1e03
_version_ 1702173243759132672
score 13.211869

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