Prevalence of Ultrasound Diagnosed Nonalcoholic Fatty Liver Disease Among Rural Indigenous Community of Sarawak And Its Association With Biochemical and Anthropometric Measures
Although the association between non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome has been previously firmly established, the prevalence of NAFLD and its risk factors in rural communities remains incompletely defined. This study aimed to determine the prevalence and factors associ...
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| Main Authors: | , , , , |
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| Format: | E-Article |
| Language: | English |
| Published: |
Southeast Asian Ministers of Education Organisation.
2013
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/11118/1/IR22.pdf http://ir.unimas.my/id/eprint/11118/ http://www.tm.mahidol.ac.th/seameo/publication.htm |
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| Summary: | Although the association between non-alcoholic fatty liver disease
(NAFLD) and metabolic syndrome has been previously firmly established, the
prevalence of NAFLD and its risk factors in rural communities remains incompletely
defined. This study aimed to determine the prevalence and factors associated
with ultrasound-diagnosed NAFLD amongst a rural community in Sarawak. An
indigenous village was randomly selected where all adults aged 21 years and above
underwent an abdominal ultrasound, biochemical tests and an anthropometric assessment.
Respondents with a score ≥ 8 on an alcohol-use disorders-identification
test (AUDIT) indicating harmful or hazardous drinking were excluded. Seventyseven
respondents (46.8% male, mean age 48.4 SD 16.64), met inclusion criteria.
The prevalence of ultrasound diagnosed NAFLD was 44.2% (n=34), among them
52.9% had moderate NAFLD. There were no significant age or gender differences
between respondents with and without NAFLD, although those with NAFLD
were older. Respondents with NAFLD had a significantly higher BMI than those
without NAFLD (p<0.001). Both male and female respondents with NAFLD had
a significantly higher waist circumference than those without NAFLD (p<0.001).
Prevalence of diabetes, hypertension, hyperglycemia and hypertriglyceridemia
were significantly higher among those with NAFLD. However, there were no significant
differences in terms of percentage of unhealthy body fat and muscle, and
serum HDL levels. Risk factors independently associated with NAFLD included
male gender (odd ratio 0.06; 95% CI 0.008-0.523) and waist circumference (odd ratio
1.2; 95% CI 1.036-1.421). There was a high prevalence of NAFLD and the presence
of more severe stages of disease in this indigenous population. Life-style related
diseases, such as fatty liver disease, can occur in rural as well as urban populations. |
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