Comparison of the growth of all four dengue virus serotypes in C6/36 and vero cell lines
Dengue virus, which is transmitted by an infected Aedes aegypti mosquito, is one of the most rampant arboviruses that have been infecting millions of people around the world. Previous studies showed that the virus propagated in different cell lines showed diverse results in different experiments con...
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| Format: | Final Year Project Report |
| Language: | English English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/10413/1/Rahmah.pdf http://ir.unimas.my/id/eprint/10413/4/Rahmah%20Fadilah%20ft.pdf http://ir.unimas.my/id/eprint/10413/ |
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| Summary: | Dengue virus, which is transmitted by an infected Aedes aegypti mosquito, is one of the most rampant arboviruses that have been infecting millions of people around the world. Previous studies showed that the virus propagated in different cell lines showed diverse results in different experiments conducted. Hence, the aim of this study is to compare the growth of all four dengue virus serotypes in both C6/36 and Vero cell lines. Three main parameters that were observed and analysed were the differences in cytopathic effect, virus titers and RNA concentration obtained from the experiment. The results obtained showed that the growth of DENV was significantly higher in C6/36 cell line compared to Vero cell line for all four DENV serotypes. Hence, this study allowed a better understanding on the susceptibility differences that occurred where high rate of viral propagated indicated a high affinity of the cell line towards dengue virus. |
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