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The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus

Ribavirin is a broad spectrum antiviral drug and has been used to treat various diseases. It has been used as a treatment for subacute sclerosis panencephalitis (SSPE) caused by measles virus infection. However, there were several adverse effects when receiving ribavirin treatment. Other than riba...

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Main Authors: Reagan Entigu, Linton @ Jerah, Samuel, Lihan, Ismail, Ahmad
Format: Article
Language:English
Published: International Journal Of Scientific & Technology Research 2013
Subjects:
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/10110/1/Reagan.pdf
http://ir.unimas.my/id/eprint/10110/
https://www.researchgate.net/publication/262416018_The_Effect_Of_Combination_Of_Octadecanoic_Acid_Methyl_Ester_And_Ribavirin_Against_Measles_Virus
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spelling my.unimas.ir.101102023-03-29T07:14:32Z http://ir.unimas.my/id/eprint/10110/ The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus Reagan Entigu, Linton @ Jerah Samuel, Lihan Ismail, Ahmad Q Science (General) Ribavirin is a broad spectrum antiviral drug and has been used to treat various diseases. It has been used as a treatment for subacute sclerosis panencephalitis (SSPE) caused by measles virus infection. However, there were several adverse effects when receiving ribavirin treatment. Other than ribavirin and vaccine, there is no cure for the disease thus medicinal plants being studied for their potential active compounds to be used as either mono or combined treatment with drugs. The objective of this study was to test antiviral activity of octadecanoic acid, methyl ester (OA), extracted from Cymbopogon nardus (sweet lemon grass) against measles virus in both mono and combination with ribavirin. The cytotoxicity and antiviral activity were tested at low concentration for the compound (25, 12.5 and 2.5 μg/ml) and ribavirin (0.1, 0.05 and 0.01 CC50). The cytotoxicity result showed that the low concentrations of both compounds have low cytotoxicity on Vero cell although there was slight increment of toxicity when they were combined. However, the combined treatment showed higher antiviral activity (p <0.05) compared to single treatment of both compounds (OA12.5 μg/ml + RBV0.05CC50: 94.38 ± 1.5%, OA12.5 μg/ml: 67.09 ± 0.2%, RBV0.05CC50: 51.12 ± 2.1%). The result has also shown that decreasing of the concentration of the combination could still maintained the antiviral activity comparable to single treatment and less cytotoxicity toward Vero cell. This study has proven that OA can be combined with commercial drug such as ribavirin to produce higher antiviral activity at lower concentration for combination of both compounds. International Journal Of Scientific & Technology Research 2013 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/10110/1/Reagan.pdf Reagan Entigu, Linton @ Jerah and Samuel, Lihan and Ismail, Ahmad (2013) The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus. International Journal Of Scientific & Technology Research, 2 (10). pp. 181-184. ISSN 2277-8616 https://www.researchgate.net/publication/262416018_The_Effect_Of_Combination_Of_Octadecanoic_Acid_Methyl_Ester_And_Ribavirin_Against_Measles_Virus
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Reagan Entigu, Linton @ Jerah
Samuel, Lihan
Ismail, Ahmad
The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
description Ribavirin is a broad spectrum antiviral drug and has been used to treat various diseases. It has been used as a treatment for subacute sclerosis panencephalitis (SSPE) caused by measles virus infection. However, there were several adverse effects when receiving ribavirin treatment. Other than ribavirin and vaccine, there is no cure for the disease thus medicinal plants being studied for their potential active compounds to be used as either mono or combined treatment with drugs. The objective of this study was to test antiviral activity of octadecanoic acid, methyl ester (OA), extracted from Cymbopogon nardus (sweet lemon grass) against measles virus in both mono and combination with ribavirin. The cytotoxicity and antiviral activity were tested at low concentration for the compound (25, 12.5 and 2.5 μg/ml) and ribavirin (0.1, 0.05 and 0.01 CC50). The cytotoxicity result showed that the low concentrations of both compounds have low cytotoxicity on Vero cell although there was slight increment of toxicity when they were combined. However, the combined treatment showed higher antiviral activity (p <0.05) compared to single treatment of both compounds (OA12.5 μg/ml + RBV0.05CC50: 94.38 ± 1.5%, OA12.5 μg/ml: 67.09 ± 0.2%, RBV0.05CC50: 51.12 ± 2.1%). The result has also shown that decreasing of the concentration of the combination could still maintained the antiviral activity comparable to single treatment and less cytotoxicity toward Vero cell. This study has proven that OA can be combined with commercial drug such as ribavirin to produce higher antiviral activity at lower concentration for combination of both compounds.
format Article
author Reagan Entigu, Linton @ Jerah
Samuel, Lihan
Ismail, Ahmad
author_facet Reagan Entigu, Linton @ Jerah
Samuel, Lihan
Ismail, Ahmad
author_sort Reagan Entigu, Linton @ Jerah
title The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
title_short The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
title_full The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
title_fullStr The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
title_full_unstemmed The Effect Of Combination Of Octadecanoic Acid, Methyl Ester And Ribavirin Against Measles Virus
title_sort effect of combination of octadecanoic acid, methyl ester and ribavirin against measles virus
publisher International Journal Of Scientific & Technology Research
publishDate 2013
url http://ir.unimas.my/id/eprint/10110/1/Reagan.pdf
http://ir.unimas.my/id/eprint/10110/
https://www.researchgate.net/publication/262416018_The_Effect_Of_Combination_Of_Octadecanoic_Acid_Methyl_Ester_And_Ribavirin_Against_Measles_Virus
_version_ 1762396639727714304
score 13.211869

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