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Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions

The growing demand for sustainable and efficient extraction methods in phytochemical research has led to increasing interest in Natural Deep Eutectic Solvents (NADES) as eco-friendly alternatives for extracting bioactive compounds from medicinal plants. Unlike conventional solvents, NADES are non-to...

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Main Authors: Huang, Mee Mee, Yiin, Chung Loong, Serene Lock, Sow Mun, Bridgid Chin, Lai Fui, Inawati, Othman, Nur Syuhada, Ahmad Zauzi, Chan, Yi Herng
Format: Article
Language:English
Published: Elsevier B.V. 2025
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
Online Access:http://ir.unimas.my/id/eprint/47640/3/Natural%20deep%20eutectic%20solvents%20-%20Copy.pdf
http://ir.unimas.my/id/eprint/47640/
https://www.sciencedirect.com/science/article/abs/pii/S016773222500368X#:~:text=NADES%20provide%20eco%2Dfriendly%20alternatives,bioactive%20compounds%20from%20various%20plants.
https://doi.org/10.1016/j.molliq.2025.127202
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spelling my.unimas.ir-476402025-02-24T02:11:54Z http://ir.unimas.my/id/eprint/47640/ Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions Huang, Mee Mee Yiin, Chung Loong Serene Lock, Sow Mun Bridgid Chin, Lai Fui Inawati, Othman Nur Syuhada, Ahmad Zauzi Chan, Yi Herng T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology The growing demand for sustainable and efficient extraction methods in phytochemical research has led to increasing interest in Natural Deep Eutectic Solvents (NADES) as eco-friendly alternatives for extracting bioactive compounds from medicinal plants. Unlike conventional solvents, NADES are non-toxic, biodegradable, and composed of natural, renewable materials, making them an attractive option for green extraction processes. This review aims to explore the potential of NADES as green solvents for extracting bioactive compounds from medicinal plants, focusing on recent advances, preparation methods, and their effectiveness in various plant extractions. The review also highlights the role of hydrogen bond donors (HBDs) in determining extraction efficiency, particularly for different bioactive compounds. While several reviews on NADES already exist, this work differentiates itself by providing a comprehensive comparison of various NADES formulations, discussing the impact of HBD choice on extraction efficiency, and identifying gaps in current research—particularly in optimizing NADES combinations for specific plant compounds. Additionally, the challenges and future directions for improving NADES-based extraction techniques are thoroughly discussed, paving the way for more sustainable and efficient extraction methods in the pharmaceutical and nutraceutical industries. Elsevier B.V. 2025-02-19 Article PeerReviewed text en http://ir.unimas.my/id/eprint/47640/3/Natural%20deep%20eutectic%20solvents%20-%20Copy.pdf Huang, Mee Mee and Yiin, Chung Loong and Serene Lock, Sow Mun and Bridgid Chin, Lai Fui and Inawati, Othman and Nur Syuhada, Ahmad Zauzi and Chan, Yi Herng (2025) Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions. Journal of Molecular Liquids, 425 (127202). pp. 1-21. ISSN 0167-7322 https://www.sciencedirect.com/science/article/abs/pii/S016773222500368X#:~:text=NADES%20provide%20eco%2Dfriendly%20alternatives,bioactive%20compounds%20from%20various%20plants. https://doi.org/10.1016/j.molliq.2025.127202
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TP Chemical technology
Huang, Mee Mee
Yiin, Chung Loong
Serene Lock, Sow Mun
Bridgid Chin, Lai Fui
Inawati, Othman
Nur Syuhada, Ahmad Zauzi
Chan, Yi Herng
Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
description The growing demand for sustainable and efficient extraction methods in phytochemical research has led to increasing interest in Natural Deep Eutectic Solvents (NADES) as eco-friendly alternatives for extracting bioactive compounds from medicinal plants. Unlike conventional solvents, NADES are non-toxic, biodegradable, and composed of natural, renewable materials, making them an attractive option for green extraction processes. This review aims to explore the potential of NADES as green solvents for extracting bioactive compounds from medicinal plants, focusing on recent advances, preparation methods, and their effectiveness in various plant extractions. The review also highlights the role of hydrogen bond donors (HBDs) in determining extraction efficiency, particularly for different bioactive compounds. While several reviews on NADES already exist, this work differentiates itself by providing a comprehensive comparison of various NADES formulations, discussing the impact of HBD choice on extraction efficiency, and identifying gaps in current research—particularly in optimizing NADES combinations for specific plant compounds. Additionally, the challenges and future directions for improving NADES-based extraction techniques are thoroughly discussed, paving the way for more sustainable and efficient extraction methods in the pharmaceutical and nutraceutical industries.
format Article
author Huang, Mee Mee
Yiin, Chung Loong
Serene Lock, Sow Mun
Bridgid Chin, Lai Fui
Inawati, Othman
Nur Syuhada, Ahmad Zauzi
Chan, Yi Herng
author_facet Huang, Mee Mee
Yiin, Chung Loong
Serene Lock, Sow Mun
Bridgid Chin, Lai Fui
Inawati, Othman
Nur Syuhada, Ahmad Zauzi
Chan, Yi Herng
author_sort Huang, Mee Mee
title Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
title_short Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
title_full Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
title_fullStr Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
title_full_unstemmed Natural deep eutectic solvents (NADES) for sustainable extraction of bioactive compounds from medicinal plants : Recent advances, challenges, and future directions
title_sort natural deep eutectic solvents (nades) for sustainable extraction of bioactive compounds from medicinal plants : recent advances, challenges, and future directions
publisher Elsevier B.V.
publishDate 2025
url http://ir.unimas.my/id/eprint/47640/3/Natural%20deep%20eutectic%20solvents%20-%20Copy.pdf
http://ir.unimas.my/id/eprint/47640/
https://www.sciencedirect.com/science/article/abs/pii/S016773222500368X#:~:text=NADES%20provide%20eco%2Dfriendly%20alternatives,bioactive%20compounds%20from%20various%20plants.
https://doi.org/10.1016/j.molliq.2025.127202
_version_ 1825166855589855232
score 13.244109

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