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Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study

Background: Limited information exists regarding the pathophysiological interactions between osteoporosis and chronic obstructive pulmonary disease (COPD). Objective: To study the association of Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-Β ligand (RANKL) in male COPD patie...

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Main Authors: Ahmad N., Bitar, Majed Ahmed, Al-Mansoub, Syed A., Syed-Sulaiman, Fadi G., Saqallah, Irfhan A.B, Hyder-Ali, Salah A., Alshehade, Amer, Hayat-Khan
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Language:English
Published: Permanyer 2024
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RM Therapeutics. Pharmacology
Online Access:http://ir.unimas.my/id/eprint/47026/1/Assessment%20of%20Osteoprotegerin.pdf
http://ir.unimas.my/id/eprint/47026/
https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=517
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spelling my.unimas.ir-470262024-12-24T07:33:50Z http://ir.unimas.my/id/eprint/47026/ Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study Ahmad N., Bitar Majed Ahmed, Al-Mansoub Syed A., Syed-Sulaiman Fadi G., Saqallah Irfhan A.B, Hyder-Ali Salah A., Alshehade Amer, Hayat-Khan RM Therapeutics. Pharmacology Background: Limited information exists regarding the pathophysiological interactions between osteoporosis and chronic obstructive pulmonary disease (COPD). Objective: To study the association of Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-Β ligand (RANKL) in male COPD patients. Methods: An observational clinical study was conducted at Penang General Hospital in Malaysia. Participants were divided into three groups: COPD patients with osteoporosis, COPD patients without osteoporosis, and healthy participants of the same age groups. Serum OPG (sOPG) and RANKL (sRANKL) levels were investigated. Results: The mean age of COPD patients was 64.10 ± 10.04 years. COPD patients had lower body mass index (23.22 ± 6.43) than healthy participants (27.32 ± 6.80). The T-score was significantly lower among COPD patients than healthy participants (p = 0.018). The sOPG concentration among healthy participants was significantly higher (361.90 ± 29.10 pg/mL, p < 0.001) than in the other groups, while the sRANKL concentration was not significantly different. The serum OPG/RANKL concentration was markedly higher in the control group than in the COPD patient group (p < 0.05). The COPD patients with osteoporosis had significantly lower pulmonary parameters (forced expiratory volume in the first [FEV]1% and FEV1/[forced vital capacity] (FVC), p < 0.01) and more dyspnea (modified medical research council = 2.60 ± 0.78 versus 1.90 ± 0.70, p < 0.01) than did the patients without osteoporosis. Furthermore, patients with severe COPD had a 3 times greater risk of developing osteoporosis (OR = 2.997 [95% CI = 2.181, 4.118], p < 0.001), while spirometric parameters had a significant inverse relationship with osteoporosis (FEV1% OR = 0.970, [95% CI = 0.954, 0.986], p = 0.001; FEV1/FVC OR = 0.984, (95% CI = 0.970, 0.999], p = 0.035). Conclusion: The study concluded that COPD patients had lower sOPG levels, leading to decreased OPG/RANKL ratio and faster bone resorption. Low bone mineral density was associated with more severe COPD. (REV INVEST CLIN. 2024;76(6):262-73) Permanyer 2024 Article PeerReviewed text en http://ir.unimas.my/id/eprint/47026/1/Assessment%20of%20Osteoprotegerin.pdf Ahmad N., Bitar and Majed Ahmed, Al-Mansoub and Syed A., Syed-Sulaiman and Fadi G., Saqallah and Irfhan A.B, Hyder-Ali and Salah A., Alshehade and Amer, Hayat-Khan (2024) Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study. Revista de Investigación Clínica, 76 (6). pp. 262-273. ISSN 2564-8896 https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=517 DOI: 10.24875/RIC.24000192
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Ahmad N., Bitar
Majed Ahmed, Al-Mansoub
Syed A., Syed-Sulaiman
Fadi G., Saqallah
Irfhan A.B, Hyder-Ali
Salah A., Alshehade
Amer, Hayat-Khan
Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
description Background: Limited information exists regarding the pathophysiological interactions between osteoporosis and chronic obstructive pulmonary disease (COPD). Objective: To study the association of Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-Β ligand (RANKL) in male COPD patients. Methods: An observational clinical study was conducted at Penang General Hospital in Malaysia. Participants were divided into three groups: COPD patients with osteoporosis, COPD patients without osteoporosis, and healthy participants of the same age groups. Serum OPG (sOPG) and RANKL (sRANKL) levels were investigated. Results: The mean age of COPD patients was 64.10 ± 10.04 years. COPD patients had lower body mass index (23.22 ± 6.43) than healthy participants (27.32 ± 6.80). The T-score was significantly lower among COPD patients than healthy participants (p = 0.018). The sOPG concentration among healthy participants was significantly higher (361.90 ± 29.10 pg/mL, p < 0.001) than in the other groups, while the sRANKL concentration was not significantly different. The serum OPG/RANKL concentration was markedly higher in the control group than in the COPD patient group (p < 0.05). The COPD patients with osteoporosis had significantly lower pulmonary parameters (forced expiratory volume in the first [FEV]1% and FEV1/[forced vital capacity] (FVC), p < 0.01) and more dyspnea (modified medical research council = 2.60 ± 0.78 versus 1.90 ± 0.70, p < 0.01) than did the patients without osteoporosis. Furthermore, patients with severe COPD had a 3 times greater risk of developing osteoporosis (OR = 2.997 [95% CI = 2.181, 4.118], p < 0.001), while spirometric parameters had a significant inverse relationship with osteoporosis (FEV1% OR = 0.970, [95% CI = 0.954, 0.986], p = 0.001; FEV1/FVC OR = 0.984, (95% CI = 0.970, 0.999], p = 0.035). Conclusion: The study concluded that COPD patients had lower sOPG levels, leading to decreased OPG/RANKL ratio and faster bone resorption. Low bone mineral density was associated with more severe COPD. (REV INVEST CLIN. 2024;76(6):262-73)
format Article
author Ahmad N., Bitar
Majed Ahmed, Al-Mansoub
Syed A., Syed-Sulaiman
Fadi G., Saqallah
Irfhan A.B, Hyder-Ali
Salah A., Alshehade
Amer, Hayat-Khan
author_facet Ahmad N., Bitar
Majed Ahmed, Al-Mansoub
Syed A., Syed-Sulaiman
Fadi G., Saqallah
Irfhan A.B, Hyder-Ali
Salah A., Alshehade
Amer, Hayat-Khan
author_sort Ahmad N., Bitar
title Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
title_short Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
title_full Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
title_fullStr Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
title_full_unstemmed Assessment of Osteoprotegerin and Receptor Activator of Nf-Κb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease : A Cross-Sectional Study
title_sort assessment of osteoprotegerin and receptor activator of nf-κb ligand in malaysian male patients with chronic obstructive pulmonary disease : a cross-sectional study
publisher Permanyer
publishDate 2024
url http://ir.unimas.my/id/eprint/47026/1/Assessment%20of%20Osteoprotegerin.pdf
http://ir.unimas.my/id/eprint/47026/
https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=517
_version_ 1819914981838159872
score 13.223943

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