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Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe

Folic acid (FA) is a crucial vitamin for the human health, and imbalanced levels of folate can result in various illnesses. A new fluorescent probe called CQDs-MSN, made from biomass carbon quantum dots and mesoporous silica, was developed through hydrothermal and template techniques to detect FA co...

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Main Authors: Wen, He, Lim, Soh Fong, Rubiyah, Baini, Jie, Lu, Yingdi, Zheng
Format: Article
Language:English
Published: Royal Society of Chemistry 2024
Subjects:
QD Chemistry
Online Access:http://ir.unimas.my/id/eprint/46956/1/Determination%20of%20Folic%20Acid.pdf
http://ir.unimas.my/id/eprint/46956/
https://pubs.rsc.org/en/content/articlelanding/2025/nj/d4nj03438d
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spelling my.unimas.ir-469562024-12-19T01:53:38Z http://ir.unimas.my/id/eprint/46956/ Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe Wen, He Lim, Soh Fong Rubiyah, Baini Jie, Lu Yingdi, Zheng QD Chemistry Folic acid (FA) is a crucial vitamin for the human health, and imbalanced levels of folate can result in various illnesses. A new fluorescent probe called CQDs-MSN, made from biomass carbon quantum dots and mesoporous silica, was developed through hydrothermal and template techniques to detect FA concentrations. By studying the fluorescence response and linear correlation ofthe CQDs-MSN with FA, the optimal conditions were determined by adjusting the reaction time and pH level.The findings indicated that the best fluorescence quenching effect occurred when the pH was 7.4, and the reaction time was 4 min. At λex=355 nm and λem=427 nm, the fluorescence emission spectra of CQDs-MSN were notably reduced due to the combined effects of static quenching and internal filtering effect when FA was present. Under optimal conditions, the detection concentration for FA ranged from 0 to 100.0 µM, with a limit of 0.18 µM. Furthermore, CQDs-MSN were effectively utilized to measure FA in real samples, including urine and rabbit serum, achieving spiked recoveries between 98.7% and 102.3%. These demonstrated that the CQDs-MSN is a suitable tool for analysing FA in biosensing applications. Royal Society of Chemistry 2024-12-13 Article PeerReviewed text en http://ir.unimas.my/id/eprint/46956/1/Determination%20of%20Folic%20Acid.pdf Wen, He and Lim, Soh Fong and Rubiyah, Baini and Jie, Lu and Yingdi, Zheng (2024) Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe. New Journal of Chemistry. pp. 1-9. ISSN 1369-9261 (In Press) https://pubs.rsc.org/en/content/articlelanding/2025/nj/d4nj03438d DOI https://doi.org/10.1039/D4NJ03438D
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Wen, He
Lim, Soh Fong
Rubiyah, Baini
Jie, Lu
Yingdi, Zheng
Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
description Folic acid (FA) is a crucial vitamin for the human health, and imbalanced levels of folate can result in various illnesses. A new fluorescent probe called CQDs-MSN, made from biomass carbon quantum dots and mesoporous silica, was developed through hydrothermal and template techniques to detect FA concentrations. By studying the fluorescence response and linear correlation ofthe CQDs-MSN with FA, the optimal conditions were determined by adjusting the reaction time and pH level.The findings indicated that the best fluorescence quenching effect occurred when the pH was 7.4, and the reaction time was 4 min. At λex=355 nm and λem=427 nm, the fluorescence emission spectra of CQDs-MSN were notably reduced due to the combined effects of static quenching and internal filtering effect when FA was present. Under optimal conditions, the detection concentration for FA ranged from 0 to 100.0 µM, with a limit of 0.18 µM. Furthermore, CQDs-MSN were effectively utilized to measure FA in real samples, including urine and rabbit serum, achieving spiked recoveries between 98.7% and 102.3%. These demonstrated that the CQDs-MSN is a suitable tool for analysing FA in biosensing applications.
format Article
author Wen, He
Lim, Soh Fong
Rubiyah, Baini
Jie, Lu
Yingdi, Zheng
author_facet Wen, He
Lim, Soh Fong
Rubiyah, Baini
Jie, Lu
Yingdi, Zheng
author_sort Wen, He
title Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
title_short Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
title_full Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
title_fullStr Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
title_full_unstemmed Determination of Folic Acid with a Novel Biomass Sourced Carbon Quantum Dots-Mesoporous Silica Fluorescent Probe
title_sort determination of folic acid with a novel biomass sourced carbon quantum dots-mesoporous silica fluorescent probe
publisher Royal Society of Chemistry
publishDate 2024
url http://ir.unimas.my/id/eprint/46956/1/Determination%20of%20Folic%20Acid.pdf
http://ir.unimas.my/id/eprint/46956/
https://pubs.rsc.org/en/content/articlelanding/2025/nj/d4nj03438d
_version_ 1818839398416908288
score 13.223943

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