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Intelligent design of microneedle structure for drug delivery system

Master of Science in Microeletronic Engineering

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Bibliographic Details
Main Author: Nur Afifah, Ismail
Other Authors: Nurul Izza, Mohd Nor, Dr.
Format: Thesis
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2015
Subjects:
Transdermal medication
Drug delivery systems
Microneedle
Microneedle > Design and construction
Transdermal drug delivery (TDD)
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063
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spelling my.unimap-770632022-11-17T04:24:52Z Intelligent design of microneedle structure for drug delivery system Nur Afifah, Ismail Nurul Izza, Mohd Nor, Dr. Transdermal medication Drug delivery systems Microneedle Microneedle -- Design and construction Transdermal drug delivery (TDD) Master of Science in Microeletronic Engineering Transdermal drug delivery (TDD) is an attractive system to transport drugs or biological compounds into human body, for its apparent benefit of eliminating pain and inconvenient intravenous injections. Microneedle is one example of TDD devices that involves various parameters and complex set of design requirements. Design and analysis of microneedle structure for drug delivery system has been an important issue among researchers especially in biological micro-electro-mechanical system (BioMEMS) field. As MEMS-based microneedles develop in complexity, there is a greater need to reduce the time taken for a MEMS designer to analyze their design before proceed to fabrication process. This study proposed the used of artificial intelligence (AI) methods as a systematic optimization tool to reduce the amount of time taken for designing a microneedle structure. An optimization of microneedle structure is demonstrated by using two techniques of AI which are particle swarm optimization (PSO) and genetic algorithm (GA). A hybrid optimization algorithm has been investigated by combining the PSO with GA to improve computation competency. This combination method is called hybrid PSO-GA (HPSOGA). There are eight design variables of microneedle structure to be optimized in this research. The complex design of microneedle structure considers the shape of microneedle, material used, size of the array, the base of microneedle, the lumen base, the height of microneedle, the height of the lumen, and the height of the drug container or reservoir. 2015 2022-11-17T04:22:40Z 2022-11-17T04:22:40Z Thesis http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063 en Universiti Malaysia Perlis (UniMAP) Universiti Malaysia Perlis (UniMAP) School of Microelectronic Engineering
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Transdermal medication
Drug delivery systems
Microneedle
Microneedle -- Design and construction
Transdermal drug delivery (TDD)
spellingShingle Transdermal medication
Drug delivery systems
Microneedle
Microneedle -- Design and construction
Transdermal drug delivery (TDD)
Nur Afifah, Ismail
Intelligent design of microneedle structure for drug delivery system
description Master of Science in Microeletronic Engineering
author2 Nurul Izza, Mohd Nor, Dr.
author_facet Nurul Izza, Mohd Nor, Dr.
Nur Afifah, Ismail
format Thesis
author Nur Afifah, Ismail
author_sort Nur Afifah, Ismail
title Intelligent design of microneedle structure for drug delivery system
title_short Intelligent design of microneedle structure for drug delivery system
title_full Intelligent design of microneedle structure for drug delivery system
title_fullStr Intelligent design of microneedle structure for drug delivery system
title_full_unstemmed Intelligent design of microneedle structure for drug delivery system
title_sort intelligent design of microneedle structure for drug delivery system
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2015
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77063
_version_ 1751537838738898944
score 13.211869

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