Cover Image

Nanogap Dielectric Biosensor for label free DNA Hybridization detection

Link to publisher's homepage at http://www.unimap.edu.my/

Saved in:
Bibliographic Details
Main Authors: Uda, Hashim, Muhamad Emi Azri, Shohini, Harbant, Singh
Other Authors: uda@unimap.edu.my
Format: Article
Language:English
Published: Universiti Malaysia Perlis 2010
Subjects:
Nanogap
DNA hybridization
Lab-on-a-chip
Spacer Patterning technology
Reverse Spacer Lithographic
Sensors
Deoxyribonucleic acid (DNA)
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/7446
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.unimap-7446
record_format dspace
spelling my.unimap-74462010-01-01T04:07:08Z Nanogap Dielectric Biosensor for label free DNA Hybridization detection Uda, Hashim Muhamad Emi Azri, Shohini Harbant, Singh uda@unimap.edu.my Nanogap DNA hybridization Lab-on-a-chip Spacer Patterning technology Reverse Spacer Lithographic Sensors Deoxyribonucleic acid (DNA) Link to publisher's homepage at http://www.unimap.edu.my/ Sensors based on nanogap capacitance changes are being developed for genomic and proteomic applications because they offer label-free detection on platforms amenable to high throughput configurations. This paper presents the development of fabrication and characterisation of lab-on-a-chip methodology for deoxyribonucleic acid (DNA) hybridization detection. The electrodes made of amorphous silicon (a-Si) separated by a narrow gap whose width is comparable to the size of a DNA molecule are used as a trap. During hybridization, trapped DNA change from single stranded DNA (ssDNA) to double stranded DNA (dsDNA) cause the change of charge density of molecules structure. This change results in an effective change of capacitance that can be monitored electronically by using dielectric spectroscopy, a type of impedance spectroscopy that measures the dielectric properties of a medium as a function of frequency. 2010-01-01T04:07:08Z 2010-01-01T04:07:08Z 2007 Article Journal of Engineering Research and Education, vol. 4, 2007, pages 41-49. 1823-2981 http://www.unimap.edu.my/ http://hdl.handle.net/123456789/7446 en Universiti Malaysia Perlis
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Nanogap
DNA hybridization
Lab-on-a-chip
Spacer Patterning technology
Reverse Spacer Lithographic
Sensors
Deoxyribonucleic acid (DNA)
spellingShingle Nanogap
DNA hybridization
Lab-on-a-chip
Spacer Patterning technology
Reverse Spacer Lithographic
Sensors
Deoxyribonucleic acid (DNA)
Uda, Hashim
Muhamad Emi Azri, Shohini
Harbant, Singh
Nanogap Dielectric Biosensor for label free DNA Hybridization detection
description Link to publisher's homepage at http://www.unimap.edu.my/
author2 uda@unimap.edu.my
author_facet uda@unimap.edu.my
Uda, Hashim
Muhamad Emi Azri, Shohini
Harbant, Singh
format Article
author Uda, Hashim
Muhamad Emi Azri, Shohini
Harbant, Singh
author_sort Uda, Hashim
title Nanogap Dielectric Biosensor for label free DNA Hybridization detection
title_short Nanogap Dielectric Biosensor for label free DNA Hybridization detection
title_full Nanogap Dielectric Biosensor for label free DNA Hybridization detection
title_fullStr Nanogap Dielectric Biosensor for label free DNA Hybridization detection
title_full_unstemmed Nanogap Dielectric Biosensor for label free DNA Hybridization detection
title_sort nanogap dielectric biosensor for label free dna hybridization detection
publisher Universiti Malaysia Perlis
publishDate 2010
url http://dspace.unimap.edu.my/xmlui/handle/123456789/7446
_version_ 1643788828728623104
score 13.222552

Similar Items