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Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection

Doctor of Philosophy in Nano electronic Engineering

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Bibliographic Details
Main Author: Tijjani Adam, Shuwa
Other Authors: Uda, Hashim, Prof. Dr.
Format: Thesis
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2015
Subjects:
Microfluids
Nanowires
Biosensors
Nano Lab-On-Chip
Nanotechnology
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/72704
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spelling my.unimap-727042021-11-18T08:21:28Z Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection Tijjani Adam, Shuwa Uda, Hashim, Prof. Dr. Microfluids Nanowires Biosensors Nano Lab-On-Chip Nanotechnology Doctor of Philosophy in Nano electronic Engineering Lab-on-chip fabricated with one-dimensional nanowires offer excellent electrical properties where bio molecular analysis at very low concentrations is becoming increasingly relevant for medical and research communities. Good number of techniques and promising results has been established for detecting small concentrations; however, for high-throughput measurements and label-free detection are still area of fresh investigation. Many research groups have reported high level of bio recognition by using semiconductor nanowire. The semiconductors silicon nanowire biosensor utilizes a Nano wire between two conducting materials. The nanowire has its atoms concentrated on its surface. Thus, any small changes in the charges present on the nanowire will cause a change in the flow of current. In this thesis, a simulation study coupled with experimental approach to explain the change in wire surface behavior as function of the surface charge. The linear behavior of the conductivity to increase the sensitivity of a semiconducting nanowire biosensor is ascertained. The silicon wire should be between 5 to 20nm to allow mean distance between atoms, the oxide should be as thin as possible for optimum surface integrity, and the functional layer should be thin and have a high dielectric constant. The ionic concentration of the electrolyte should be kept low in order to have a large Debye screening length. To confirm these theoretical results, Silicon nanowire of ≈ 15nm was fabricated using conventional photolithography coupled with dry etching process. To determine the capability of the device, it subjected to various pH values and to achieve this, the device is being operated based on the principle of Field Effect Transistor (FET). The surface of the device is hole dominated (p-type material). 2015 2021-11-05T01:43:47Z 2021-11-05T01:43:47Z Thesis http://dspace.unimap.edu.my:80/xmlui/handle/123456789/72704 en Universiti Malaysia Perlis (UniMAP) Universiti Malaysia Perlis (UniMAP) Institute of Nano Electronic Engineering
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Microfluids
Nanowires
Biosensors
Nano Lab-On-Chip
Nanotechnology
spellingShingle Microfluids
Nanowires
Biosensors
Nano Lab-On-Chip
Nanotechnology
Tijjani Adam, Shuwa
Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
description Doctor of Philosophy in Nano electronic Engineering
author2 Uda, Hashim, Prof. Dr.
author_facet Uda, Hashim, Prof. Dr.
Tijjani Adam, Shuwa
format Thesis
author Tijjani Adam, Shuwa
author_sort Tijjani Adam, Shuwa
title Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_short Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_full Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_fullStr Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_full_unstemmed Development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
title_sort development of silicon nanowire lab-on-chip microfluidics integrated biosensor for low concentration bio-molecules detection
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2015
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/72704
_version_ 1724609940595671040
score 13.211869

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