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Design of fully intergrated impedimetric CMOS biosensor for DNA detection

Link to publisher's homepage at http://ijneam.unimap.edu.my/

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Main Authors: Siu Fan, Vinny Lam, Yusmeeraz, Yusof
Other Authors: yusmeeraz@fke.utm.my.
Format: Article
Language:English
Published: Universiti Malaysia Perlis 2016
Subjects:
CMOS
Biosensor
Impedance
Label-free DNA
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41318
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spelling my.unimap-413182017-11-21T01:55:47Z Design of fully intergrated impedimetric CMOS biosensor for DNA detection Siu Fan, Vinny Lam Yusmeeraz, Yusof yusmeeraz@fke.utm.my. CMOS Biosensor Impedance Label-free DNA Link to publisher's homepage at http://ijneam.unimap.edu.my/ This paper described a label-free and fully integrated impedimetric biosensor using standard Complementary Metal Oxide Semiconductor (CMOS) technology to measure both capacitance and resistance of the electrode-electrolyte interface. Conventional impedance biosensors usually use bulky and expensive instruments to monitor the impedance change. This paper demonstrate a low power, high gain and low cost impedance readout circuit design for detecting the biomolecular interactions of deoxyribonucleic acid (DNA) strands at the electrode surface. The proposed biosensor circuit is composed of a transimpedance amplifier (TIA) with two quadrature phase mixers and finally integrated with 5 μm x 5 μm microelectrode based on 0.18 μm Silterra CMOS technology process with 1.8 V supply. The output value of the readout circuit is used to estimate the amplitude and phase of the meausred admittance. The developed TIA can achieve a gain of 88.6dB up to frequency of 50MHz. It also has very good linearity up to 2.7mA and the overall dynamic range is approximately 90dB. . 2016-04-22T08:36:02Z 2016-04-22T08:36:02Z 2015 Article International Journal of Nanoelectronics and Materials, vol.8 (1), 2015, pages 55-60 1985-5761 (Printed) 1997-4434 (Online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41318 en Universiti Malaysia Perlis
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic CMOS
Biosensor
Impedance
Label-free DNA
spellingShingle CMOS
Biosensor
Impedance
Label-free DNA
Siu Fan, Vinny Lam
Yusmeeraz, Yusof
Design of fully intergrated impedimetric CMOS biosensor for DNA detection
description Link to publisher's homepage at http://ijneam.unimap.edu.my/
author2 yusmeeraz@fke.utm.my.
author_facet yusmeeraz@fke.utm.my.
Siu Fan, Vinny Lam
Yusmeeraz, Yusof
format Article
author Siu Fan, Vinny Lam
Yusmeeraz, Yusof
author_sort Siu Fan, Vinny Lam
title Design of fully intergrated impedimetric CMOS biosensor for DNA detection
title_short Design of fully intergrated impedimetric CMOS biosensor for DNA detection
title_full Design of fully intergrated impedimetric CMOS biosensor for DNA detection
title_fullStr Design of fully intergrated impedimetric CMOS biosensor for DNA detection
title_full_unstemmed Design of fully intergrated impedimetric CMOS biosensor for DNA detection
title_sort design of fully intergrated impedimetric cmos biosensor for dna detection
publisher Universiti Malaysia Perlis
publishDate 2016
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/41318
_version_ 1643802796854607872
score 13.222552

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