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In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites

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Main Authors: Andriani, Yosephine, Morrow, Isabel C., Taran, Elena, Edwards, Grant A., Schiller, Tara L., Azlin Fazlina, Osman, Martin, Darren J.
Other Authors: yosephineandriani@uqconnect.edu.au
Format: Article
Language:English
Published: Elsevier Ltd. 2014
Subjects:
Biomaterial
Biostability
Nanocomposite
Organoclay
Polyurethane
Online Access:http://dspace.unimap.edu.my:80/dspace/handle/123456789/32753
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spelling my.unimap-327532014-03-14T07:45:54Z In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites Andriani, Yosephine Morrow, Isabel C. Taran, Elena Edwards, Grant A. Schiller, Tara L. Azlin Fazlina, Osman Martin, Darren J. yosephineandriani@uqconnect.edu.au g.edwards1@uq.edu.au tara.schiller@monash.edu.au azlin@unimap.edu.my darren.martin@uq.edu.au Biomaterial Biostability Nanocomposite Organoclay Polyurethane Link to publisher's homepage at https://www.elsevier.com/‎ We have prepared a number of silicone-based thermoplastic polyurethane (TPU) nanocomposites and demonstrated an enhancement of in vitro biostability against metal-ion-induced oxidation for potential use in long-term implantable medical devices. Organoclays based on both low-aspect-ratio hectorites and high-aspect-ratio fluoromicas were evaluated after being dual-modified with two quaternary alkyl ammonium salts with differing degrees of polarity. The resultant nanocomposites were tested for in vitro biostability using physiologically relevant oxidizing conditions. Subsequently, the effects of oxidative treatment on the surface degradation and bulk mechanical integrity of the nanocomposites were investigated and compared with the parent TPUs to identify nanocomposites with the most desirable features for long-term implantation. Here, we demonstrate that the low-aspect-ratio organohectorite was delaminated and well dispersed in the nanocomposites. Importantly, these factors gave rise to the enhanced oxidative stability. In addition, the mechanical properties of all nanocomposites were less adversely affected by the oxidative treatment compared to their parent TPUs. These results suggest the potential for improved mechanical integrity and biostability when suitable dual modified organoclays are incorporated in a silicone-based TPU. 2014-03-14T07:45:54Z 2014-03-14T07:45:54Z 2013-09 Article Acta Biomaterialia, vol. 9(9), 2013, pages 8308-8317 1742-7061 http://www.sciencedirect.com/science/article/pii/S1742706113002705 http://dspace.unimap.edu.my:80/dspace/handle/123456789/32753 en Elsevier Ltd.
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Biomaterial
Biostability
Nanocomposite
Organoclay
Polyurethane
spellingShingle Biomaterial
Biostability
Nanocomposite
Organoclay
Polyurethane
Andriani, Yosephine
Morrow, Isabel C.
Taran, Elena
Edwards, Grant A.
Schiller, Tara L.
Azlin Fazlina, Osman
Martin, Darren J.
In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
description Link to publisher's homepage at https://www.elsevier.com/‎
author2 yosephineandriani@uqconnect.edu.au
author_facet yosephineandriani@uqconnect.edu.au
Andriani, Yosephine
Morrow, Isabel C.
Taran, Elena
Edwards, Grant A.
Schiller, Tara L.
Azlin Fazlina, Osman
Martin, Darren J.
format Article
author Andriani, Yosephine
Morrow, Isabel C.
Taran, Elena
Edwards, Grant A.
Schiller, Tara L.
Azlin Fazlina, Osman
Martin, Darren J.
author_sort Andriani, Yosephine
title In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
title_short In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
title_full In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
title_fullStr In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
title_full_unstemmed In vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
title_sort in vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocomposites
publisher Elsevier Ltd.
publishDate 2014
url http://dspace.unimap.edu.my:80/dspace/handle/123456789/32753
_version_ 1643796974677262336
score 13.222552

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