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Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing

The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Po...

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Main Author: Ngadaonye, Jude
Format: Other
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2013
Subjects:
Chitosan-PDEAAm IPN
Novel
Potential wound dressing
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/30893
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spelling my.unimap-308932013-12-27T07:05:22Z Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing Ngadaonye, Jude Chitosan-PDEAAm IPN Novel Potential wound dressing The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia A novel interactive and thermoresponsive interpenetrating polymer network wound dressing which is mostly transparent, permeable to oxygen, and easily stripped from a wound bed, was synthesised by a rapid photopolymerisation and crosslinking of DEAAm in the presence of chitosan. To our knowledge, these study and results provide the first evaluation and optimisation of a UV-polymerised chitosan-PDEAAm IPN composite film for wound dressing application. FTIR spectroscopy and DSC analysis were used to characterise the resulting films. The films exhibited adequate mechanical properties to be used as a wound/burn dressing and from the MDSC and swelling studies were found to switch from slightly hydrophilic to a highly hydrophilic surface upon subjection to solution at a lower temperature. This thermosensitive property allows the dressing to be easily detachable and enables frequent dressing change if desired or removal without causing further injury to healing tissues. There was no significant difference in the oxygen permeability values and mechanical properties, although the mechanical properties could be slightly improved upon. The results from the water sorption tests are in the typical and desired ranges for commercial wound dressings, and even better than some currently available in the market. The results showed that the DCG 20-77.5-2.5 chitosan-PDEAAm composite film had the best potential to be employed as a moist wound dressing due to its high water content compared to the other compositions. This means it has the capacity to retain a moist environment over a wound for much longer thereby facilitating the healing process. It also has a high WVTR value (895.2 + 117 g/m2/day), similar to that of DCG 20-75-5 (909.6 + 168 g/m2/day) which suggests that these chitosan-PDEAAm membranes would be suitable for lightly to moderately exudating wounds. The peel adhesion test results showed that the films can swell and become less adhesive at lower temperatures. A cold pack can be placed over the film prior to dressing removal, it swells and detaches easily from a wound site, thus, helping to prevent the secondary injury usually associated with dressing changes/removal. The ease of removal of the chitosan-PDEAAm dressing from a wound site due to its switchable hydrophilicity further enhances its potential application. Gentamicin-loaded chitosan-PDEAAm dressings showed excellent inhibition towards the growth of S. aureus and P. aeruginosa, hence confirming the efficacy of the antibiotic was not compromised by the films’ preparation process. This inhibitory effect on bacterial viability can significantly improve the wound healing process compared with gauze control or a conventional hydrogel dressing without drug 2013-12-27T07:05:21Z 2013-12-27T07:05:21Z 2012-06-18 Other p. 1287 978-967-5760-11-2 http://hdl.handle.net/123456789/30893 en The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012); Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Chitosan-PDEAAm IPN
Novel
Potential wound dressing
spellingShingle Chitosan-PDEAAm IPN
Novel
Potential wound dressing
Ngadaonye, Jude
Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
description The 2nd International Malaysia-Ireland Joint Symposium on Engineering, Science and Business 2012 (IMiEJS2012) jointly organized by Universiti Malaysia Perlis and Athlone Institute of Technology in collaboration with The Ministry of Higher Education (MOHE) Malaysia, Education Malaysia and Malaysia Postgraduates Student Association Ireland (MyPSI), 18th - 19th June 2012 at Putra World Trade Center (PWTC), Kuala Lumpur, Malaysia
format Other
author Ngadaonye, Jude
author_facet Ngadaonye, Jude
author_sort Ngadaonye, Jude
title Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
title_short Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
title_full Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
title_fullStr Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
title_full_unstemmed Development of a novel thermosensitive chitosan-PDEAAm IPN and its characterisation as a potential wound dressing
title_sort development of a novel thermosensitive chitosan-pdeaam ipn and its characterisation as a potential wound dressing
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2013
url http://dspace.unimap.edu.my/xmlui/handle/123456789/30893
_version_ 1643796408658034688
score 13.222552

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