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Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons

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Main Authors: Mrunal, Rane, Aagam, Shah, Shivani, Sheth, Rohit, Manchanda, Prof
Other Authors: mrunal.rane@djsce.ac.in
Format: Working Paper
Language:English
Published: Institute of Electrical and Electronics Engineers (IEEE) 2012
Subjects:
Bi modal behavior
Integration
Medium Spiny Neuron (MSN)
Nucleus accumbens
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/21420
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spelling my.unimap-214202012-10-18T08:30:50Z Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons Mrunal, Rane Aagam, Shah Shivani, Sheth Rohit, Manchanda, Prof mrunal.rane@djsce.ac.in rmanch@iitb.ac.in Bi modal behavior Integration Medium Spiny Neuron (MSN) Nucleus accumbens Link to publisher's homepage at http://ieeexplore.ieee.org/ Reward circuit is considered as the major site at which many drugs of abuse act. The nucleus accumbens (NAcc) plays an important role in the reward circuit and it constitutes the major subdivision of the ventral striatum. Medium Spiny Neuron (MSN), is the principal neuron of Nucleus accumbens (Nacc) and is known to possess bimodal behavior. Due to the bi modal behavior of the cell, there are significant discrepancies in the shape of the EPSP generated in the cell. A change in the active conductances of the cells causes a significant change in the nature of the EPSP generated. The effect of Sodium and Potassium channels is explored to understand their effect on MSN excitability. 2012-10-18T08:30:50Z 2012-10-18T08:30:50Z 2012-02-27 Working Paper p. 562-566 978-145771989-9 http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6178980 http://hdl.handle.net/123456789/21420 en Proceedings of the International Conference on Biomedical Engineering (ICoBE 2012) Institute of Electrical and Electronics Engineers (IEEE)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Bi modal behavior
Integration
Medium Spiny Neuron (MSN)
Nucleus accumbens
spellingShingle Bi modal behavior
Integration
Medium Spiny Neuron (MSN)
Nucleus accumbens
Mrunal, Rane
Aagam, Shah
Shivani, Sheth
Rohit, Manchanda, Prof
Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
description Link to publisher's homepage at http://ieeexplore.ieee.org/
author2 mrunal.rane@djsce.ac.in
author_facet mrunal.rane@djsce.ac.in
Mrunal, Rane
Aagam, Shah
Shivani, Sheth
Rohit, Manchanda, Prof
format Working Paper
author Mrunal, Rane
Aagam, Shah
Shivani, Sheth
Rohit, Manchanda, Prof
author_sort Mrunal, Rane
title Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
title_short Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
title_full Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
title_fullStr Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
title_full_unstemmed Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
title_sort computational investigation of effects of up state on epsp in striatal medium spiny neurons
publisher Institute of Electrical and Electronics Engineers (IEEE)
publishDate 2012
url http://dspace.unimap.edu.my/xmlui/handle/123456789/21420
_version_ 1643793395230965760
score 13.222552

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