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New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants

For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found th...

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Main Authors: Straathof, A. J. J., Heijnen, J. J.
Format: Article
Language:English
Published: John Wiley & Sons, Inc. 2008
Subjects:
Enzyme kinetics.
Parameter estimation.
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/1503
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spelling my.unimap-15032008-08-07T01:22:45Z New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants Straathof, A. J. J. Heijnen, J. J. Enzyme kinetics. Parameter estimation. For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found the additional constraints between the parameters. These relations allow to predict in which situation rate constants are identifiable by steady-state kinetic methods. 2008-08-07T01:22:45Z 2008-08-07T01:22:45Z 1996 Article Biotechnology and Bioengineering, vol. 52, issue 3, 1996, pages 433-437 00063592 http://hdl.handle.net/123456789/1503 en John Wiley & Sons, Inc.
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Enzyme kinetics.
Parameter estimation.
spellingShingle Enzyme kinetics.
Parameter estimation.
Straathof, A. J. J.
Heijnen, J. J.
New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
description For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found the additional constraints between the parameters. These relations allow to predict in which situation rate constants are identifiable by steady-state kinetic methods.
format Article
author Straathof, A. J. J.
Heijnen, J. J.
author_facet Straathof, A. J. J.
Heijnen, J. J.
author_sort Straathof, A. J. J.
title New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_short New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_full New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_fullStr New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_full_unstemmed New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_sort new constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
publisher John Wiley & Sons, Inc.
publishDate 2008
url http://dspace.unimap.edu.my/xmlui/handle/123456789/1503
_version_ 1643787340235145216
score 13.222552

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