Staff View: A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.

A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.

The secondary metabolites that marine sponges create are essential to the advancement of contemporary medicine and are often employed in clinical settings. Over the past five years, microbes associated with sponges have yielded the identification of 140 novel chemicals. Statistics show that most are...

Full description

Saved in:

Bibliographic Details
Main Authors:	Noora Barzkar, Stanislav Sukhikh, Olga Babich
Format:	Article
Language:	English
Published:	Elsevier 2024
Subjects:	QE1-350.62 General Including geographical divisions QR1-502 Microbiology
Online Access:	https://eprints.ums.edu.my/id/eprint/43032/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/43032/ https://doi.org/10.1016/j.ijbiomac.2024.135823
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.ums.eprints.43032
record_format	eprints
spelling	my.ums.eprints.430322025-03-05T05:36:04Z https://eprints.ums.edu.my/id/eprint/43032/ A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp. Noora Barzkar Stanislav Sukhikh Olga Babich QE1-350.62 General Including geographical divisions QR1-502 Microbiology The secondary metabolites that marine sponges create are essential to the advancement of contemporary medicine and are often employed in clinical settings. Over the past five years, microbes associated with sponges have yielded the identification of 140 novel chemicals. Statistics show that most are derived from actinomycetes (bacteria) and ascomycotes (fungi). The aim of this study was to investigate the biological activity of metabolites from marine sponges. Chlocarbazomycins A-D, which are a group of novel chlorinated carbazole alkaloids isolated from the sponge Neopetrosia fennelliae KUFA 0811, exhibit antimicrobial, cytotoxic, and enzyme inhibitory activities. Recently, marine sponges of the genus Neopetrosia have attracted attention due to the unique chemical composition of the compounds they produce, including alkaloids of potential importance in drug discovery. Fridamycin H and fridamycin I are two novel type II polyketides synthesized by sponge-associated bacteria exhibit antitrypanosomal activity. Fintiamin, composed of amino acids and terpenoid moieties, shows affinity for the cannabinoid receptor CB 1. It was found that out of 27 species of Neopetrosia sponges, the chemical composition of only 9 species has been studied. These species mainly produce bioactive substances such as alkaloids, quinones, sterols, and terpenoids. The presence of motuporamines is a marker of the species Neopetrosia exigua. Terpenoids are specific markers of Neopetrosia vanilla species. Although recently discovered, secondary metabolites from marine sponges have been shown to have diverse biological activities, antimicrobial, antiviral, antibacterial, antimicrobial, antioxidant, antimalarial, and anticancer properties, providing many lead compounds for drug development. The data presented in this review on known and future natural products derived from sponges will further clarify the role and importance of microbes in marine sponges and trace the prospects of their applications, especially in medicine, cosmeceuticals, environmental protection, and manufacturing industries. Elsevier 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/43032/1/FULL%20TEXT.pdf Noora Barzkar and Stanislav Sukhikh and Olga Babich (2024) A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp. International Journal of Biological Macromolecules, 280. pp. 1-18. ISSN 0141-8130 https://doi.org/10.1016/j.ijbiomac.2024.135823
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English
topic	QE1-350.62 General Including geographical divisions QR1-502 Microbiology
spellingShingle	QE1-350.62 General Including geographical divisions QR1-502 Microbiology Noora Barzkar Stanislav Sukhikh Olga Babich A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
description	The secondary metabolites that marine sponges create are essential to the advancement of contemporary medicine and are often employed in clinical settings. Over the past five years, microbes associated with sponges have yielded the identification of 140 novel chemicals. Statistics show that most are derived from actinomycetes (bacteria) and ascomycotes (fungi). The aim of this study was to investigate the biological activity of metabolites from marine sponges. Chlocarbazomycins A-D, which are a group of novel chlorinated carbazole alkaloids isolated from the sponge Neopetrosia fennelliae KUFA 0811, exhibit antimicrobial, cytotoxic, and enzyme inhibitory activities. Recently, marine sponges of the genus Neopetrosia have attracted attention due to the unique chemical composition of the compounds they produce, including alkaloids of potential importance in drug discovery. Fridamycin H and fridamycin I are two novel type II polyketides synthesized by sponge-associated bacteria exhibit antitrypanosomal activity. Fintiamin, composed of amino acids and terpenoid moieties, shows affinity for the cannabinoid receptor CB 1. It was found that out of 27 species of Neopetrosia sponges, the chemical composition of only 9 species has been studied. These species mainly produce bioactive substances such as alkaloids, quinones, sterols, and terpenoids. The presence of motuporamines is a marker of the species Neopetrosia exigua. Terpenoids are specific markers of Neopetrosia vanilla species. Although recently discovered, secondary metabolites from marine sponges have been shown to have diverse biological activities, antimicrobial, antiviral, antibacterial, antimicrobial, antioxidant, antimalarial, and anticancer properties, providing many lead compounds for drug development. The data presented in this review on known and future natural products derived from sponges will further clarify the role and importance of microbes in marine sponges and trace the prospects of their applications, especially in medicine, cosmeceuticals, environmental protection, and manufacturing industries.
format	Article
author	Noora Barzkar Stanislav Sukhikh Olga Babich
author_facet	Noora Barzkar Stanislav Sukhikh Olga Babich
author_sort	Noora Barzkar
title	A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
title_short	A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
title_full	A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
title_fullStr	A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
title_full_unstemmed	A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.
title_sort	comprehensive review of marine sponge metabolites, with emphasis on neopetrosia sp.
publisher	Elsevier
publishDate	2024
url	https://eprints.ums.edu.my/id/eprint/43032/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/43032/ https://doi.org/10.1016/j.ijbiomac.2024.135823
_version_	1825809978702692352
score	13.244413

A comprehensive review of marine sponge metabolites, with emphasis on Neopetrosia sp.

Similar Items