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Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study

Stress is necessary and inevitable, but in excess is deleterious to the physical and mental well-being of any animal species. Stressful experiences during pregnancy lead to development of impairments that become evident in prepubertal as well as adult stages. Pyramid models constructed with the same...

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Main Author: Mitchel Constance George
Format: Thesis
Language:English
English
Published: 2013
Subjects:
QP1-345 General Including influence of the environment
Online Access:https://eprints.ums.edu.my/id/eprint/42512/1/24%20PAGES.pdf
https://eprints.ums.edu.my/id/eprint/42512/2/FULLTEXT.pdf
https://eprints.ums.edu.my/id/eprint/42512/
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spelling my.ums.eprints.425122025-01-07T00:43:43Z https://eprints.ums.edu.my/id/eprint/42512/ Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study Mitchel Constance George QP1-345 General Including influence of the environment Stress is necessary and inevitable, but in excess is deleterious to the physical and mental well-being of any animal species. Stressful experiences during pregnancy lead to development of impairments that become evident in prepubertal as well as adult stages. Pyramid models constructed with the same base to height ratio as the Great Pyramid of Giza, when aligned on a true north-south axis, is believed to generate, transform and transmit energy which has beneficial effects. The present study was carried out to assess the effects of housing pregnant Sprague Dawley rats subjected to restraint-stress outside (RC) and under the pyramid (RP) as compared to unstressed normal controls (NC) and its effects on the offspring morphometric and physical development, plasma corticosterone levels and hippocampal Cornu Ammonis (CA3) pyramidal neuron arborisation. The results showed a delay of one day in the fur appearance, pinna detachment, ear and eye opening in RC which was significant when compared to NC, while there was no such delay in the RP offspring. Significant decrease in head, body and tail length along with decrease in body and brain weight in RC group was also seen when compared to NC, but not in the RP offspring. Significant hypertrophy of adrenal gland and increase in plasma corticosterone was seen in the stressed mothers. The results were similar to those we found in our earlier work on adult rats and mice. Similar hypertrophy of adrenal glands and increase in plasma corticosterone was also seen at Postnatal Day (PND) 10, 21, 40 and 60 of the offspring's born to the stressed mothers, indicating presence the of stress induced in the Hypothalamo- Pituitary-Adrenal (HPA) axis of the foetus. RC group showed significant decrease at PND 10, 21, 40 and 60 in both the apical and basal dendritic arborisation when compared to NC and RP offspring. The effects were more significant at PND 10 and 21 which is just before weaning, and the effect became lesser after they were being weaned from the mothers and until adulthood. Thus, the geometric shape of the pyramid and the energy generated within helps reduce the effects of stress probably by suppressing the HPA axis. This study suggests the therapeutic potential of the geometric shape of buildings that could be used to reduce stress and stress related mental diseases. This study prompts us to explore the rehabilitation effects of previously stressed animals under the pyramid in the future. 2013 Thesis NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42512/1/24%20PAGES.pdf text en https://eprints.ums.edu.my/id/eprint/42512/2/FULLTEXT.pdf Mitchel Constance George (2013) Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study. Masters thesis, Universiti Malaysia Sabah.
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QP1-345 General Including influence of the environment
spellingShingle QP1-345 General Including influence of the environment
Mitchel Constance George
Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
description Stress is necessary and inevitable, but in excess is deleterious to the physical and mental well-being of any animal species. Stressful experiences during pregnancy lead to development of impairments that become evident in prepubertal as well as adult stages. Pyramid models constructed with the same base to height ratio as the Great Pyramid of Giza, when aligned on a true north-south axis, is believed to generate, transform and transmit energy which has beneficial effects. The present study was carried out to assess the effects of housing pregnant Sprague Dawley rats subjected to restraint-stress outside (RC) and under the pyramid (RP) as compared to unstressed normal controls (NC) and its effects on the offspring morphometric and physical development, plasma corticosterone levels and hippocampal Cornu Ammonis (CA3) pyramidal neuron arborisation. The results showed a delay of one day in the fur appearance, pinna detachment, ear and eye opening in RC which was significant when compared to NC, while there was no such delay in the RP offspring. Significant decrease in head, body and tail length along with decrease in body and brain weight in RC group was also seen when compared to NC, but not in the RP offspring. Significant hypertrophy of adrenal gland and increase in plasma corticosterone was seen in the stressed mothers. The results were similar to those we found in our earlier work on adult rats and mice. Similar hypertrophy of adrenal glands and increase in plasma corticosterone was also seen at Postnatal Day (PND) 10, 21, 40 and 60 of the offspring's born to the stressed mothers, indicating presence the of stress induced in the Hypothalamo- Pituitary-Adrenal (HPA) axis of the foetus. RC group showed significant decrease at PND 10, 21, 40 and 60 in both the apical and basal dendritic arborisation when compared to NC and RP offspring. The effects were more significant at PND 10 and 21 which is just before weaning, and the effect became lesser after they were being weaned from the mothers and until adulthood. Thus, the geometric shape of the pyramid and the energy generated within helps reduce the effects of stress probably by suppressing the HPA axis. This study suggests the therapeutic potential of the geometric shape of buildings that could be used to reduce stress and stress related mental diseases. This study prompts us to explore the rehabilitation effects of previously stressed animals under the pyramid in the future.
format Thesis
author Mitchel Constance George
author_facet Mitchel Constance George
author_sort Mitchel Constance George
title Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
title_short Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
title_full Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
title_fullStr Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
title_full_unstemmed Effects of prenatal stress on the rat offspring's hippocampal CA3 neurons and the influence of pyramid environment : a morphological and biochemical study
title_sort effects of prenatal stress on the rat offspring's hippocampal ca3 neurons and the influence of pyramid environment : a morphological and biochemical study
publishDate 2013
url https://eprints.ums.edu.my/id/eprint/42512/1/24%20PAGES.pdf
https://eprints.ums.edu.my/id/eprint/42512/2/FULLTEXT.pdf
https://eprints.ums.edu.my/id/eprint/42512/
_version_ 1821003227558051840
score 13.244413

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