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A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases

Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and...

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Main Authors: Nur Zuliani Ramli, Mohamad Fairuz Yahaya, Ikuo Tooyama, Hanafi Ahmad Damanhuri
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2020
Subjects:
QP1-345 General Including influence of the environment
RA421-790.95 Public health. Hygiene. Preventive medicine
Online Access:https://eprints.ums.edu.my/id/eprint/42463/1/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/42463/
http://dx.doi.org/10.3390/antiox9101019
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spelling my.ums.eprints.424632024-12-31T01:20:59Z https://eprints.ums.edu.my/id/eprint/42463/ A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases Nur Zuliani Ramli Mohamad Fairuz Yahaya Ikuo Tooyama Hanafi Ahmad Damanhuri QP1-345 General Including influence of the environment RA421-790.95 Public health. Hygiene. Preventive medicine Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and PD share the similar involvement of oxidative stress in their pathophysiology. Nutraceuticals exert their antioxidative effects via direct scavenging of free radicals, prevent damage to biomolecules, indirectly stimulate the endogenous antioxidative enzymes and gene expressions, inhibit activation of pro-oxidant enzymes, and chelate metals. In addition, nutraceuticals can act as modulators of pro-survival, pro-apoptotic, and inflammatory signaling pathways. They have been shown to be effective particularly in preclinical stages, due to their multiple mechanisms of action in attenuating oxidative stress underlying AD and PD. Natural antioxidants from food sources and natural products such as resveratrol, curcumin, green tea polyphenols, and vitamin E are promising therapeutic agents in oxidative stress-mediated neurodegenerative disease as they have fewer adverse effects, more tolerable, cheaper, and sustainable for long term consumption. Multidisciplinary Digital Publishing Institute (MDPI) 2020 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42463/1/FULL%20TEXT.pdf Nur Zuliani Ramli and Mohamad Fairuz Yahaya and Ikuo Tooyama and Hanafi Ahmad Damanhuri (2020) A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases. Antioxidants, 9. pp. 1-41. http://dx.doi.org/10.3390/antiox9101019
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QP1-345 General Including influence of the environment
RA421-790.95 Public health. Hygiene. Preventive medicine
spellingShingle QP1-345 General Including influence of the environment
RA421-790.95 Public health. Hygiene. Preventive medicine
Nur Zuliani Ramli
Mohamad Fairuz Yahaya
Ikuo Tooyama
Hanafi Ahmad Damanhuri
A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
description Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and PD share the similar involvement of oxidative stress in their pathophysiology. Nutraceuticals exert their antioxidative effects via direct scavenging of free radicals, prevent damage to biomolecules, indirectly stimulate the endogenous antioxidative enzymes and gene expressions, inhibit activation of pro-oxidant enzymes, and chelate metals. In addition, nutraceuticals can act as modulators of pro-survival, pro-apoptotic, and inflammatory signaling pathways. They have been shown to be effective particularly in preclinical stages, due to their multiple mechanisms of action in attenuating oxidative stress underlying AD and PD. Natural antioxidants from food sources and natural products such as resveratrol, curcumin, green tea polyphenols, and vitamin E are promising therapeutic agents in oxidative stress-mediated neurodegenerative disease as they have fewer adverse effects, more tolerable, cheaper, and sustainable for long term consumption.
format Article
author Nur Zuliani Ramli
Mohamad Fairuz Yahaya
Ikuo Tooyama
Hanafi Ahmad Damanhuri
author_facet Nur Zuliani Ramli
Mohamad Fairuz Yahaya
Ikuo Tooyama
Hanafi Ahmad Damanhuri
author_sort Nur Zuliani Ramli
title A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
title_short A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
title_full A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
title_fullStr A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
title_full_unstemmed A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
title_sort mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2020
url https://eprints.ums.edu.my/id/eprint/42463/1/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/42463/
http://dx.doi.org/10.3390/antiox9101019
_version_ 1821003220793688064
score 13.244413

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