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Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation

According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resista...

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Main Authors:	Nur Farisya Shamsudin, Qamar Uddin Ahmed, Syed Mahmood, Syed Adnan Ali Shah, Alfi Khatib, Sayeed Mukhtar, Meshari A. Alsharif, Humaira Parveen, Zainul Amiruddin Zakaria
Format:	Article
Language:	English
Published:	Molecular Diversity Preservation International 2022
Subjects:	R856-857 Biomedical engineering. Electronics. Instrumentation RM1-950 Therapeutics. Pharmacology
Online Access:	https://eprints.ums.edu.my/id/eprint/42390/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42390/ https://doi.org/10.3390/molecules27041149
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id	my.ums.eprints.42390
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spelling	my.ums.eprints.423902024-12-26T03:15:05Z https://eprints.ums.edu.my/id/eprint/42390/ Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation Nur Farisya Shamsudin Qamar Uddin Ahmed Syed Mahmood Syed Adnan Ali Shah Alfi Khatib Sayeed Mukhtar Meshari A. Alsharif Humaira Parveen Zainul Amiruddin Zakaria R856-857 Biomedical engineering. Electronics. Instrumentation RM1-950 Therapeutics. Pharmacology According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of biofilm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, flavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrugresistant bacteria. The hydroxylation of C5, C7, C30 , and C40 ; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of flavonoids. On the other hand, methoxylation at C30 and C5 has been reported to decrease flavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products Molecular Diversity Preservation International 2022 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42390/1/FULL%20TEXT.pdf Nur Farisya Shamsudin and Qamar Uddin Ahmed and Syed Mahmood and Syed Adnan Ali Shah and Alfi Khatib and Sayeed Mukhtar and Meshari A. Alsharif and Humaira Parveen and Zainul Amiruddin Zakaria (2022) Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation. Molecules, 27. pp. 1-43. https://doi.org/10.3390/molecules27041149
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English
topic	R856-857 Biomedical engineering. Electronics. Instrumentation RM1-950 Therapeutics. Pharmacology
spellingShingle	R856-857 Biomedical engineering. Electronics. Instrumentation RM1-950 Therapeutics. Pharmacology Nur Farisya Shamsudin Qamar Uddin Ahmed Syed Mahmood Syed Adnan Ali Shah Alfi Khatib Sayeed Mukhtar Meshari A. Alsharif Humaira Parveen Zainul Amiruddin Zakaria Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
description	According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of biofilm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, flavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrugresistant bacteria. The hydroxylation of C5, C7, C30 , and C40 ; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of flavonoids. On the other hand, methoxylation at C30 and C5 has been reported to decrease flavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products
format	Article
author	Nur Farisya Shamsudin Qamar Uddin Ahmed Syed Mahmood Syed Adnan Ali Shah Alfi Khatib Sayeed Mukhtar Meshari A. Alsharif Humaira Parveen Zainul Amiruddin Zakaria
author_facet	Nur Farisya Shamsudin Qamar Uddin Ahmed Syed Mahmood Syed Adnan Ali Shah Alfi Khatib Sayeed Mukhtar Meshari A. Alsharif Humaira Parveen Zainul Amiruddin Zakaria
author_sort	Nur Farisya Shamsudin
title	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_short	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_full	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_fullStr	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_full_unstemmed	Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
title_sort	antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation
publisher	Molecular Diversity Preservation International
publishDate	2022
url	https://eprints.ums.edu.my/id/eprint/42390/1/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42390/ https://doi.org/10.3390/molecules27041149
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score	13.223943

Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation

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