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Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity

Garcinia mangostana extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety of bioactive components. GME has proven its anti-Acanthamoeba effectiveness. In this investigation, a GMEloaded niosome was developed to increase its potential therapeutic efficacy. A GME-loaded nio...

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Main Authors:	Suthinee Sangkana, Komgrit Eawsakul, Tassanee Ongtanasup, Rachasak Boonhok, Watcharapong Mitsuwan, Siriphorn Chimplee, Alok K. Paul, Shanmuga Sundar Saravanabhavan, Tooba Mahboob, Muhammad Nawaz, Maria L. Pereira, Polrat Wilairatana, Christophe Wiart, Veeranoot Nissapatorn
Format:	Article
Language:	English English
Published:	Nanoscale Advances 2024
Subjects:	QL360-599.82 Invertebrates RM300-666 Drugs and their actions
Online Access:	https://eprints.ums.edu.my/id/eprint/42079/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/42079/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42079/ https://doi.org/10.1039/D3NA01016C
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spelling	my.ums.eprints.420792024-11-29T04:37:19Z https://eprints.ums.edu.my/id/eprint/42079/ Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity Suthinee Sangkana Komgrit Eawsakul Tassanee Ongtanasup Rachasak Boonhok Watcharapong Mitsuwan Siriphorn Chimplee Alok K. Paul Shanmuga Sundar Saravanabhavan Tooba Mahboob Muhammad Nawaz Maria L. Pereira Polrat Wilairatana Christophe Wiart Veeranoot Nissapatorn QL360-599.82 Invertebrates RM300-666 Drugs and their actions Garcinia mangostana extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety of bioactive components. GME has proven its anti-Acanthamoeba effectiveness. In this investigation, a GMEloaded niosome was developed to increase its potential therapeutic efficacy. A GME-loaded niosome was prepared by encapsulation in a mixture of span60, cholesterol, and chloroform by the thin film hydration method. The vesicle size, zeta potential, percentage of entrapment efficiency, and stability of GME-loaded niosomes were investigated. The values for GME-loaded niosome size and zeta potential were 404.23 ± 4.59 and −32.03 ± 0.95, respectively. The delivery system enhanced the anti-Acanthamoeba activity, which possessed MIC values of 0.25–4 mg mL−1 . In addition, the niosomal formulation decreased the toxicity of GME by 16 times. GME-loaded niosome must be stored at 4 °C, as the quantity of remaining GME encapsulated is greater at this temperature than at room temperature. SEM revealed the damage to the cell membrane caused by trophozoites and cysts, which led to dead cells. In light of the above, it was found that GME-loaded niosomes had better anti-Acanthamoeba activity. The study suggested that GMEloaded niosomes could be used as an alternative to Acanthamoeba's therapeutic effects. Nanoscale Advances 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/42079/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/42079/2/FULL%20TEXT.pdf Suthinee Sangkana and Komgrit Eawsakul and Tassanee Ongtanasup and Rachasak Boonhok and Watcharapong Mitsuwan and Siriphorn Chimplee and Alok K. Paul and Shanmuga Sundar Saravanabhavan and Tooba Mahboob and Muhammad Nawaz and Maria L. Pereira and Polrat Wilairatana and Christophe Wiart and Veeranoot Nissapatorn (2024) Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity. Royal Society of Chemistry. pp. 1-13. https://doi.org/10.1039/D3NA01016C
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	QL360-599.82 Invertebrates RM300-666 Drugs and their actions
spellingShingle	QL360-599.82 Invertebrates RM300-666 Drugs and their actions Suthinee Sangkana Komgrit Eawsakul Tassanee Ongtanasup Rachasak Boonhok Watcharapong Mitsuwan Siriphorn Chimplee Alok K. Paul Shanmuga Sundar Saravanabhavan Tooba Mahboob Muhammad Nawaz Maria L. Pereira Polrat Wilairatana Christophe Wiart Veeranoot Nissapatorn Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
description	Garcinia mangostana extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety of bioactive components. GME has proven its anti-Acanthamoeba effectiveness. In this investigation, a GMEloaded niosome was developed to increase its potential therapeutic efficacy. A GME-loaded niosome was prepared by encapsulation in a mixture of span60, cholesterol, and chloroform by the thin film hydration method. The vesicle size, zeta potential, percentage of entrapment efficiency, and stability of GME-loaded niosomes were investigated. The values for GME-loaded niosome size and zeta potential were 404.23 ± 4.59 and −32.03 ± 0.95, respectively. The delivery system enhanced the anti-Acanthamoeba activity, which possessed MIC values of 0.25–4 mg mL−1 . In addition, the niosomal formulation decreased the toxicity of GME by 16 times. GME-loaded niosome must be stored at 4 °C, as the quantity of remaining GME encapsulated is greater at this temperature than at room temperature. SEM revealed the damage to the cell membrane caused by trophozoites and cysts, which led to dead cells. In light of the above, it was found that GME-loaded niosomes had better anti-Acanthamoeba activity. The study suggested that GMEloaded niosomes could be used as an alternative to Acanthamoeba's therapeutic effects.
format	Article
author	Suthinee Sangkana Komgrit Eawsakul Tassanee Ongtanasup Rachasak Boonhok Watcharapong Mitsuwan Siriphorn Chimplee Alok K. Paul Shanmuga Sundar Saravanabhavan Tooba Mahboob Muhammad Nawaz Maria L. Pereira Polrat Wilairatana Christophe Wiart Veeranoot Nissapatorn
author_facet	Suthinee Sangkana Komgrit Eawsakul Tassanee Ongtanasup Rachasak Boonhok Watcharapong Mitsuwan Siriphorn Chimplee Alok K. Paul Shanmuga Sundar Saravanabhavan Tooba Mahboob Muhammad Nawaz Maria L. Pereira Polrat Wilairatana Christophe Wiart Veeranoot Nissapatorn
author_sort	Suthinee Sangkana
title	Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
title_short	Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
title_full	Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
title_fullStr	Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
title_full_unstemmed	Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
title_sort	preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity
publisher	Nanoscale Advances
publishDate	2024
url	https://eprints.ums.edu.my/id/eprint/42079/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/42079/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/42079/ https://doi.org/10.1039/D3NA01016C
_version_	1817843855002697728
score	13.239859

Preparation and evaluation of a nosocomial delivery system containing g. mangostana extract and study of its anti-acanthamoeba activity

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