Staff View: The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia

The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia

Introduction: Leukaemia is the fourth leading cause of death among children aged 0 to 14. This study aimed to determine the prognostic factors of death in childhood leukaemia in Malaysia. Methods: A retrospective cohort study was conducted for all childhood leukaemia patients aged 0 to 19 years diag...

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Main Authors:	Nabihah Ali, Saihpudin@Sahipudin Saupin, Balqis Bahtiar, Shamsul Bahari Shamsudin
Format:	Article
Language:	English English
Published:	Universiti Putra Malaysia 2023
Subjects:	RC633-647.5 Diseases of the blood and blood-forming organs RJ370-550 Diseases of children and adolescents
Online Access:	https://eprints.ums.edu.my/id/eprint/41994/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/41994/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/41994/
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spelling	my.ums.eprints.419942024-11-26T05:34:58Z https://eprints.ums.edu.my/id/eprint/41994/ The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia Nabihah Ali Saihpudin@Sahipudin Saupin Balqis Bahtiar Shamsul Bahari Shamsudin RC633-647.5 Diseases of the blood and blood-forming organs RJ370-550 Diseases of children and adolescents Introduction: Leukaemia is the fourth leading cause of death among children aged 0 to 14. This study aimed to determine the prognostic factors of death in childhood leukaemia in Malaysia. Methods: A retrospective cohort study was conducted for all childhood leukaemia patients aged 0 to 19 years diagnosed between 2010 and 2014 using data from the Malaysian National Cancer Registry database. Death dates were updated until 31st December 2019. The Cox proportional hazard model was used to determine the prognostic factors and hazard ratios. Results: Among the 1,212 children with leukaemia, females had a 19% (HR: 0.81, 95% CI: 0.68, 0.96) reduced risk of death than males. Meanwhile, patients aged less than one year, or between 10-14 and 15-19 years old reported adjusted hazard ratios of 1.7 (p<0.05), 1.7 (p<0.001), and 2.2 (p<0.001), respectively, when compared with patients aged 1-4 years old. Malay children with leukaemia had a 33% (HR: 1.33, 95% CI: 1.05, 1.68) higher risk of mortality than the Chinese. Patients with Mature B-cell (1a2) subtypes, acute myeloid leukaemia (AML) (1b) subtypes, and “unspecified and other” leukaemia (1e) subtypes showed 1.6 (p<0.05), 1.5 (p<0.001), and 1.6 (p<0.001) times the risk of death as compared to acute lymphoid leukaemia (ALL) (1a1) subtypes. Conclusion: Sex, age, ethnicity, and leukaemia subtypes were the four prognostic factors of mortality among pediatric patients. Early detection and treatment may improve childhood leukaemia survival. Universiti Putra Malaysia 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/41994/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/41994/2/FULL%20TEXT.pdf Nabihah Ali and Saihpudin@Sahipudin Saupin and Balqis Bahtiar and Shamsul Bahari Shamsudin (2023) The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia. Malaysian Journal of Medicine and Health Sciences, 19. pp. 64-71. ISSN 2636-9346
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	RC633-647.5 Diseases of the blood and blood-forming organs RJ370-550 Diseases of children and adolescents
spellingShingle	RC633-647.5 Diseases of the blood and blood-forming organs RJ370-550 Diseases of children and adolescents Nabihah Ali Saihpudin@Sahipudin Saupin Balqis Bahtiar Shamsul Bahari Shamsudin The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
description	Introduction: Leukaemia is the fourth leading cause of death among children aged 0 to 14. This study aimed to determine the prognostic factors of death in childhood leukaemia in Malaysia. Methods: A retrospective cohort study was conducted for all childhood leukaemia patients aged 0 to 19 years diagnosed between 2010 and 2014 using data from the Malaysian National Cancer Registry database. Death dates were updated until 31st December 2019. The Cox proportional hazard model was used to determine the prognostic factors and hazard ratios. Results: Among the 1,212 children with leukaemia, females had a 19% (HR: 0.81, 95% CI: 0.68, 0.96) reduced risk of death than males. Meanwhile, patients aged less than one year, or between 10-14 and 15-19 years old reported adjusted hazard ratios of 1.7 (p<0.05), 1.7 (p<0.001), and 2.2 (p<0.001), respectively, when compared with patients aged 1-4 years old. Malay children with leukaemia had a 33% (HR: 1.33, 95% CI: 1.05, 1.68) higher risk of mortality than the Chinese. Patients with Mature B-cell (1a2) subtypes, acute myeloid leukaemia (AML) (1b) subtypes, and “unspecified and other” leukaemia (1e) subtypes showed 1.6 (p<0.05), 1.5 (p<0.001), and 1.6 (p<0.001) times the risk of death as compared to acute lymphoid leukaemia (ALL) (1a1) subtypes. Conclusion: Sex, age, ethnicity, and leukaemia subtypes were the four prognostic factors of mortality among pediatric patients. Early detection and treatment may improve childhood leukaemia survival.
format	Article
author	Nabihah Ali Saihpudin@Sahipudin Saupin Balqis Bahtiar Shamsul Bahari Shamsudin
author_facet	Nabihah Ali Saihpudin@Sahipudin Saupin Balqis Bahtiar Shamsul Bahari Shamsudin
author_sort	Nabihah Ali
title	The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
title_short	The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
title_full	The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
title_fullStr	The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
title_full_unstemmed	The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia
title_sort	determinants and prognostic factors of 5-year survival of childhood leukaemia in malaysia
publisher	Universiti Putra Malaysia
publishDate	2023
url	https://eprints.ums.edu.my/id/eprint/41994/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/41994/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/41994/
_version_	1817843836283518976
score	13.222552

The determinants and prognostic factors of 5-year survival of childhood leukaemia in Malaysia

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