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Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats

Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysian Borneo, but HPAI has circulated in poultry and migratory...

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Main Authors: Hannah Klim, Timothy William, Jack Mellors, Caolann Brady, Giri S. Rajahram, Tock H. Chua, Helena Brazal Monzó, Jecelyn Leslie John, Mohammad Saffree Jeffree, Nigel J. Temperton, Tom Tipton, Craig P. Thompson, Kamruddin Ahmed, Chris J. Drakeley, Miles W. Carroll, Kimberly M. Fornace
Format: Article
Language:English
English
Published: Springer Nature Limited 2024
Subjects:
QR1-74.5 General
RA648.5-767 Epidemics. Epidemiology. Quarantine. Disinfection
Online Access:https://eprints.ums.edu.my/id/eprint/41968/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/41968/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/41968/
https://doi.org/10.1038/s41467-024-53058-y
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spelling my.ums.eprints.419682024-11-20T02:46:01Z https://eprints.ums.edu.my/id/eprint/41968/ Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats Hannah Klim Timothy William Jack Mellors Caolann Brady Giri S. Rajahram Tock H. Chua Helena Brazal Monzó Jecelyn Leslie John Mohammad Saffree Jeffree Nigel J. Temperton Tom Tipton Craig P. Thompson Kamruddin Ahmed Chris J. Drakeley Miles W. Carroll Kimberly M. Fornace QR1-74.5 General RA648.5-767 Epidemics. Epidemiology. Quarantine. Disinfection Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysian Borneo, but HPAI has circulated in poultry and migratory avian species transiting through the region. Recent deforestation in coastal habitats in Malaysian Borneo may increase the proximity between humans and migratory birds. We hypothesise that higher rates of human-animal contact, caused by this habitat destruction, will increase the likelihood of potential zoonotic spillover events. In 2015, an environmentally stratified cross-sectional survey was conducted collecting geolocated questionnaire data in 10,100 individuals. A serological survey of these individuals reveals evidence of H5 neutralisation that persisted following depletion of seasonal H1/H3 HA binding antibodies from the plasma. The presence of these antibodies suggests that some individuals living near migratory sites may have been exposed to H5 HA. There is a spatial and environmental overlap between individuals displaying high H5 HA binding and the distribution of migratory birds. We have developed a novel surveillance approach including both spatial and serological data to detect potential spillover events, highlighting the urgent need to study cross-species pathogen transmission in migratory zones. Springer Nature Limited 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/41968/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/41968/2/FULL%20TEXT.pdf Hannah Klim and Timothy William and Jack Mellors and Caolann Brady and Giri S. Rajahram and Tock H. Chua and Helena Brazal Monzó and Jecelyn Leslie John and Mohammad Saffree Jeffree and Nigel J. Temperton and Tom Tipton and Craig P. Thompson and Kamruddin Ahmed and Chris J. Drakeley and Miles W. Carroll and Kimberly M. Fornace (2024) Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats. Nature communications, 15 (8863). pp. 1-13. https://doi.org/10.1038/s41467-024-53058-y
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QR1-74.5 General
RA648.5-767 Epidemics. Epidemiology. Quarantine. Disinfection
spellingShingle QR1-74.5 General
RA648.5-767 Epidemics. Epidemiology. Quarantine. Disinfection
Hannah Klim
Timothy William
Jack Mellors
Caolann Brady
Giri S. Rajahram
Tock H. Chua
Helena Brazal Monzó
Jecelyn Leslie John
Mohammad Saffree Jeffree
Nigel J. Temperton
Tom Tipton
Craig P. Thompson
Kamruddin Ahmed
Chris J. Drakeley
Miles W. Carroll
Kimberly M. Fornace
Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
description Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No human cases of H5 infection have been reported in Malaysian Borneo, but HPAI has circulated in poultry and migratory avian species transiting through the region. Recent deforestation in coastal habitats in Malaysian Borneo may increase the proximity between humans and migratory birds. We hypothesise that higher rates of human-animal contact, caused by this habitat destruction, will increase the likelihood of potential zoonotic spillover events. In 2015, an environmentally stratified cross-sectional survey was conducted collecting geolocated questionnaire data in 10,100 individuals. A serological survey of these individuals reveals evidence of H5 neutralisation that persisted following depletion of seasonal H1/H3 HA binding antibodies from the plasma. The presence of these antibodies suggests that some individuals living near migratory sites may have been exposed to H5 HA. There is a spatial and environmental overlap between individuals displaying high H5 HA binding and the distribution of migratory birds. We have developed a novel surveillance approach including both spatial and serological data to detect potential spillover events, highlighting the urgent need to study cross-species pathogen transmission in migratory zones.
format Article
author Hannah Klim
Timothy William
Jack Mellors
Caolann Brady
Giri S. Rajahram
Tock H. Chua
Helena Brazal Monzó
Jecelyn Leslie John
Mohammad Saffree Jeffree
Nigel J. Temperton
Tom Tipton
Craig P. Thompson
Kamruddin Ahmed
Chris J. Drakeley
Miles W. Carroll
Kimberly M. Fornace
author_facet Hannah Klim
Timothy William
Jack Mellors
Caolann Brady
Giri S. Rajahram
Tock H. Chua
Helena Brazal Monzó
Jecelyn Leslie John
Mohammad Saffree Jeffree
Nigel J. Temperton
Tom Tipton
Craig P. Thompson
Kamruddin Ahmed
Chris J. Drakeley
Miles W. Carroll
Kimberly M. Fornace
author_sort Hannah Klim
title Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
title_short Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
title_full Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
title_fullStr Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
title_full_unstemmed Serological analysis in humans in Malaysian Borneo suggests prior exposure to H5 avian influenza near migratory shorebird habitats
title_sort serological analysis in humans in malaysian borneo suggests prior exposure to h5 avian influenza near migratory shorebird habitats
publisher Springer Nature Limited
publishDate 2024
url https://eprints.ums.edu.my/id/eprint/41968/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/41968/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/41968/
https://doi.org/10.1038/s41467-024-53058-y
_version_ 1817843832329338880
score 13.250246

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