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First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia

Spinal tuberculosis, also referred to as Pott’s disease, presents a significant risk of severe paralysis if not promptly detected and treated, owing to complications such as spinal cord compression and deformity. This article presents the genetic analysis of a Mycobacterium tuberculosis STB-T1A stra...

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Main Authors: Kai Ling Chin, Eraniyah Jastan Suing, Ruhini Andong, Choong Hoon Foo, Sook Kwan Chan, Jaeyres Jani, Kamruddin Ahmed, Zainal Arifin Mustapha
Format: Article
Language:English
English
Published: Elsevier 2024
Subjects:
QR75-99.5 Bacteria
RC306-320.5 Tuberculosis
Online Access:https://eprints.ums.edu.my/id/eprint/39243/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/39243/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/39243/
https://doi.org/10.1016/j.dib.2024.110476
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spelling my.ums.eprints.392432024-07-19T08:22:35Z https://eprints.ums.edu.my/id/eprint/39243/ First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia Kai Ling Chin Eraniyah Jastan Suing Ruhini Andong Choong Hoon Foo Sook Kwan Chan Jaeyres Jani Kamruddin Ahmed Zainal Arifin Mustapha QR75-99.5 Bacteria RC306-320.5 Tuberculosis Spinal tuberculosis, also referred to as Pott’s disease, presents a significant risk of severe paralysis if not promptly detected and treated, owing to complications such as spinal cord compression and deformity. This article presents the genetic analysis of a Mycobacterium tuberculosis STB-T1A strain, isolated from the spine of a 29-year-old female diagnosed with spinal tuberculosis. Genomic DNA was extracted from pure culture and subjected to sequencing using the Illumina NovaSeq 6000 sequencing system. The genome of the M. tuberculosis STB-T1A strain spans 4,367,616 base pairs with a G+C content of 65.56 % and 4174 protein-coding genes. Comparative genomic analysis, conducted via single nucleotide polymorphism (SNP)-based phylogenetic analysis using the Maximum Likelihood method, revealed that the strain falls within the Indo-Oceanic lineage (Lineage 1). It clusters with the M. tuberculosis 43-16836 strain, which was isolated from the cerebrospinal fluid of a patient with tuberculous meningitis in Thailand. The complete genome sequence has been deposited at the National Center for Biotechnology Information (NCBI) GenBank database with the accession number JBBMVZ000000000. Elsevier 2024 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/39243/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/39243/2/FULL%20TEXT.pdf Kai Ling Chin and Eraniyah Jastan Suing and Ruhini Andong and Choong Hoon Foo and Sook Kwan Chan and Jaeyres Jani and Kamruddin Ahmed and Zainal Arifin Mustapha (2024) First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia. Science direct. pp. 1-7. ISSN 2352-3409 https://doi.org/10.1016/j.dib.2024.110476
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QR75-99.5 Bacteria
RC306-320.5 Tuberculosis
spellingShingle QR75-99.5 Bacteria
RC306-320.5 Tuberculosis
Kai Ling Chin
Eraniyah Jastan Suing
Ruhini Andong
Choong Hoon Foo
Sook Kwan Chan
Jaeyres Jani
Kamruddin Ahmed
Zainal Arifin Mustapha
First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
description Spinal tuberculosis, also referred to as Pott’s disease, presents a significant risk of severe paralysis if not promptly detected and treated, owing to complications such as spinal cord compression and deformity. This article presents the genetic analysis of a Mycobacterium tuberculosis STB-T1A strain, isolated from the spine of a 29-year-old female diagnosed with spinal tuberculosis. Genomic DNA was extracted from pure culture and subjected to sequencing using the Illumina NovaSeq 6000 sequencing system. The genome of the M. tuberculosis STB-T1A strain spans 4,367,616 base pairs with a G+C content of 65.56 % and 4174 protein-coding genes. Comparative genomic analysis, conducted via single nucleotide polymorphism (SNP)-based phylogenetic analysis using the Maximum Likelihood method, revealed that the strain falls within the Indo-Oceanic lineage (Lineage 1). It clusters with the M. tuberculosis 43-16836 strain, which was isolated from the cerebrospinal fluid of a patient with tuberculous meningitis in Thailand. The complete genome sequence has been deposited at the National Center for Biotechnology Information (NCBI) GenBank database with the accession number JBBMVZ000000000.
format Article
author Kai Ling Chin
Eraniyah Jastan Suing
Ruhini Andong
Choong Hoon Foo
Sook Kwan Chan
Jaeyres Jani
Kamruddin Ahmed
Zainal Arifin Mustapha
author_facet Kai Ling Chin
Eraniyah Jastan Suing
Ruhini Andong
Choong Hoon Foo
Sook Kwan Chan
Jaeyres Jani
Kamruddin Ahmed
Zainal Arifin Mustapha
author_sort Kai Ling Chin
title First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
title_short First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
title_full First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
title_fullStr First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
title_full_unstemmed First whole genome sequencing data of a Mycobacterium tuberculosis STB-T1A strain isolated from a spinal tuberculosis patient in Sabah, Malaysia
title_sort first whole genome sequencing data of a mycobacterium tuberculosis stb-t1a strain isolated from a spinal tuberculosis patient in sabah, malaysia
publisher Elsevier
publishDate 2024
url https://eprints.ums.edu.my/id/eprint/39243/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/39243/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/39243/
https://doi.org/10.1016/j.dib.2024.110476
_version_ 1805887938101248000
score 13.211869

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