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Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia

Introduction: The association between colorectal cancer (CRC), ethnicity, and dietary practices have been well studied. However, limited studies have been conducted to assess dietary practices and ethnicity in Sabah on risk of CRC. This study aimed to assess the risk and protective factors in dietar...

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Main Authors:	Wen-Li Tee, Fredie Robinson, Richard Avoi, Prabakaran Dhanaraj, Nirmal Kaur, Nur Hasanah Sanudin
Format:	Article
Language:	English English
Published:	Universiti Putra Malaysia 2023
Subjects:	RA773-788 Personal health and hygiene Including clothing, bathing, exercise, travel, nutrition, sleep, sex hygiene RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Online Access:	https://eprints.ums.edu.my/id/eprint/39058/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/39058/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/39058/
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spelling	my.ums.eprints.390582024-07-11T08:24:44Z https://eprints.ums.edu.my/id/eprint/39058/ Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia Wen-Li Tee Fredie Robinson Richard Avoi Prabakaran Dhanaraj Nirmal Kaur Nur Hasanah Sanudin RA773-788 Personal health and hygiene Including clothing, bathing, exercise, travel, nutrition, sleep, sex hygiene RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Introduction: The association between colorectal cancer (CRC), ethnicity, and dietary practices have been well studied. However, limited studies have been conducted to assess dietary practices and ethnicity in Sabah on risk of CRC. This study aimed to assess the risk and protective factors in dietary practices and the inclusion of ethnicity and dietary practices as risk predictors for CRC. Methods: 148 CRC patients, 609 controls were recruited in this case-control study. Logistic regression analyses were performed to determine significant predictors of CRC. Prediction model was computed using Logistic Regression (LR) and C5 Decision Tree algorithms and compared. Results: Age 60-69 (aOR = 7.44, 95% CI = 3.69-15.00); male (aOR = 4.49, 95% CI = 2.67-7.54), Chinese (aOR = 32.32, 95% CI = 7.20-145.13); moderate physical activity (aOR = 3.67, 95% CI = 2.03-6.63), pickled mango (aOR = 5.66, 95% CI = 1.62-19.81), pork (aOR = 2.29, 95% CI = 1.09-4.79) increased the odds of developing CRC. No comorbidities (aOR = 0.53, 95% CI = 0.31-0.91), tertiary education attainment (aOR = 0.18, 95% CI = 0.07-0.43) were protective against CRC. Hosmer-Lemeshow test indicated good fit of the model (p =.946) and excellent discriminatory power (AUC=0.877). LR prediction model demonstrated better overall accuracy (89.2%), discriminatory power (AUC=0.82), sensitivity (77%), and specificity (91%) than the C5 Model. Conclusion: Frequent consumption of pickled mangoes and pork increased CRC risk among the Sabah population. Inclusion of ethnicity and dietary practices as predictors could potentially improve risk stratification of the Sabah population for early CRC screening Universiti Putra Malaysia 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/39058/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/39058/2/FULL%20TEXT.pdf Wen-Li Tee and Fredie Robinson and Richard Avoi and Prabakaran Dhanaraj and Nirmal Kaur and Nur Hasanah Sanudin (2023) Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia. Malaysian Journal of Medicine and Health Sciences, 19. pp. 1-16. ISSN 2636-9346
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	RA773-788 Personal health and hygiene Including clothing, bathing, exercise, travel, nutrition, sleep, sex hygiene RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
spellingShingle	RA773-788 Personal health and hygiene Including clothing, bathing, exercise, travel, nutrition, sleep, sex hygiene RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Wen-Li Tee Fredie Robinson Richard Avoi Prabakaran Dhanaraj Nirmal Kaur Nur Hasanah Sanudin Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
description	Introduction: The association between colorectal cancer (CRC), ethnicity, and dietary practices have been well studied. However, limited studies have been conducted to assess dietary practices and ethnicity in Sabah on risk of CRC. This study aimed to assess the risk and protective factors in dietary practices and the inclusion of ethnicity and dietary practices as risk predictors for CRC. Methods: 148 CRC patients, 609 controls were recruited in this case-control study. Logistic regression analyses were performed to determine significant predictors of CRC. Prediction model was computed using Logistic Regression (LR) and C5 Decision Tree algorithms and compared. Results: Age 60-69 (aOR = 7.44, 95% CI = 3.69-15.00); male (aOR = 4.49, 95% CI = 2.67-7.54), Chinese (aOR = 32.32, 95% CI = 7.20-145.13); moderate physical activity (aOR = 3.67, 95% CI = 2.03-6.63), pickled mango (aOR = 5.66, 95% CI = 1.62-19.81), pork (aOR = 2.29, 95% CI = 1.09-4.79) increased the odds of developing CRC. No comorbidities (aOR = 0.53, 95% CI = 0.31-0.91), tertiary education attainment (aOR = 0.18, 95% CI = 0.07-0.43) were protective against CRC. Hosmer-Lemeshow test indicated good fit of the model (p =.946) and excellent discriminatory power (AUC=0.877). LR prediction model demonstrated better overall accuracy (89.2%), discriminatory power (AUC=0.82), sensitivity (77%), and specificity (91%) than the C5 Model. Conclusion: Frequent consumption of pickled mangoes and pork increased CRC risk among the Sabah population. Inclusion of ethnicity and dietary practices as predictors could potentially improve risk stratification of the Sabah population for early CRC screening
format	Article
author	Wen-Li Tee Fredie Robinson Richard Avoi Prabakaran Dhanaraj Nirmal Kaur Nur Hasanah Sanudin
author_facet	Wen-Li Tee Fredie Robinson Richard Avoi Prabakaran Dhanaraj Nirmal Kaur Nur Hasanah Sanudin
author_sort	Wen-Li Tee
title	Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
title_short	Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
title_full	Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
title_fullStr	Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
title_full_unstemmed	Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia
title_sort	ethnicity and dietary practices as colorectal cancer risk predictors: a retrospective case-control study in sabah, malaysia
publisher	Universiti Putra Malaysia
publishDate	2023
url	https://eprints.ums.edu.my/id/eprint/39058/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/39058/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/39058/
_version_	1805887912095514624
score	13.211869

Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia

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