A preliminary study on the association between pro inflammatory cytokine IL-1b polymorphisms and susceptibility to hepatitis C infection in Malay male Malay drug abusers
Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during inna...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Biomedical Research and Therapy
2023
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/37908/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/37908/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/37908/ https://doi.org/10.15419/bmrat.v10i2.794 |
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| Summary: | Introduction: Hepatitis C virus (HCV) infection frequently leads to liver complications, such as fibrosis, cirrhosis, and hepatocellular carcinoma. The incidence of HCV infection transmission among drug abusers is concerning. Interleukin-1β (IL-1β) is a pro-inflammatory cytokine secreted during innate and adaptive immune responses and plays a pivotal role in chronic inflammatory diseases. Functional single nucleotide polymorphisms in IL-1β cause it to play different roles in disease susceptibility and progression. This study aimed to investigate the association between genetic polymorphisms of pro-inflammatory cytokines (IL-1β) and HCV infection susceptibility in Malay male drug abusers. Methods: In total, 48 male Malay drug abusers were included in this retrospective case-control study. Genomic DNA was extracted from whole blood samples and analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the IL1β rs16944 and rs1143634 polymorphisms. Results: Analysis of IL-1β rs1143634 revealed that the C/C genotype was common in both the case and control groups; however, no statistical significance was observed (p = 0.068, χ 2= 3.755). Genotyping of IL-1β demonstrated that all samples were of the homozygous mutant type (T/T). Conclusion: There was no association between IL-1β polymorphism (rs1143634 and rs16944) and hepatitis C infection susceptibility among Malay male drug abusers. |
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