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Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review

Endometrial receptivity is a state of the endometrium defined by its readiness for embryo implantation. When the receptivity of the endometrium is impaired due to hyperandrogenism or androgen excess, this condition can lead to pregnancy loss or infertility. Hyperandrogenism encompasses a wide range...

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Main Authors: Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman, Adila A. Hamid, Norhazlina Abdul Wahab, Mohd Helmy Mokhtar
Format: Article
Language:English
English
Published: Molecular Diversity Preservation International (MDPI) 2023
Subjects:
RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
RG159-208 Functional and systemic disorders. Endocrine gynecology
Online Access:https://eprints.ums.edu.my/id/eprint/37494/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/37494/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/37494/
https://doi.org/10.3390/ijms241512026
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spelling my.ums.eprints.374942023-10-13T07:53:40Z https://eprints.ums.edu.my/id/eprint/37494/ Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review Allia Najmie Muhammad Yusuf Mohd Fariz Amri Azizah Ugusman Adila A. Hamid Norhazlina Abdul Wahab Mohd Helmy Mokhtar RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RG159-208 Functional and systemic disorders. Endocrine gynecology Endometrial receptivity is a state of the endometrium defined by its readiness for embryo implantation. When the receptivity of the endometrium is impaired due to hyperandrogenism or androgen excess, this condition can lead to pregnancy loss or infertility. Hyperandrogenism encompasses a wide range of clinical manifestations, including polycystic ovary syndrome (PCOS), idiopathic hirsutism, hirsutism and hyperandrogaenemia, non-classical congenital adrenal hyperplasia, hyperandrogenism, insulin resistance, acanthosis nigricans (HAIR-AN), ovarian or adrenal androgensecreting neoplasms, Cushing’s syndrome, and hyperprolactinaemia. Recurrent miscarriages have been shown to be closely related to elevated testosterone levels, which alter the endometrial milieu so that it is less favourable for embryo implantation. There are mechanisms for endometrial receptivity that are affected by excess androgen. The HOXA gene, aVβ3 integrin, CDK signalling pathway, MECA-79, and MAGEA-11 were the genes and proteins affect endometrial receptivity in the presence of a hyperandrogenic state. In this review, we would like to explore the other manifestations of androgen excess focusing on causes other than PCOS and learn possible mechanisms of endometrial receptivity behind androgen excess leading to pregnancy loss or infertility Molecular Diversity Preservation International (MDPI) 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/37494/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/37494/2/FULL%20TEXT.pdf Allia Najmie Muhammad Yusuf and Mohd Fariz Amri and Azizah Ugusman and Adila A. Hamid and Norhazlina Abdul Wahab and Mohd Helmy Mokhtar (2023) Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review. International Journal of Molecular Sciences. pp. 1-18. ISSN 1422-0067 https://doi.org/10.3390/ijms241512026
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
RG159-208 Functional and systemic disorders. Endocrine gynecology
spellingShingle RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
RG159-208 Functional and systemic disorders. Endocrine gynecology
Allia Najmie Muhammad Yusuf
Mohd Fariz Amri
Azizah Ugusman
Adila A. Hamid
Norhazlina Abdul Wahab
Mohd Helmy Mokhtar
Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
description Endometrial receptivity is a state of the endometrium defined by its readiness for embryo implantation. When the receptivity of the endometrium is impaired due to hyperandrogenism or androgen excess, this condition can lead to pregnancy loss or infertility. Hyperandrogenism encompasses a wide range of clinical manifestations, including polycystic ovary syndrome (PCOS), idiopathic hirsutism, hirsutism and hyperandrogaenemia, non-classical congenital adrenal hyperplasia, hyperandrogenism, insulin resistance, acanthosis nigricans (HAIR-AN), ovarian or adrenal androgensecreting neoplasms, Cushing’s syndrome, and hyperprolactinaemia. Recurrent miscarriages have been shown to be closely related to elevated testosterone levels, which alter the endometrial milieu so that it is less favourable for embryo implantation. There are mechanisms for endometrial receptivity that are affected by excess androgen. The HOXA gene, aVβ3 integrin, CDK signalling pathway, MECA-79, and MAGEA-11 were the genes and proteins affect endometrial receptivity in the presence of a hyperandrogenic state. In this review, we would like to explore the other manifestations of androgen excess focusing on causes other than PCOS and learn possible mechanisms of endometrial receptivity behind androgen excess leading to pregnancy loss or infertility
format Article
author Allia Najmie Muhammad Yusuf
Mohd Fariz Amri
Azizah Ugusman
Adila A. Hamid
Norhazlina Abdul Wahab
Mohd Helmy Mokhtar
author_facet Allia Najmie Muhammad Yusuf
Mohd Fariz Amri
Azizah Ugusman
Adila A. Hamid
Norhazlina Abdul Wahab
Mohd Helmy Mokhtar
author_sort Allia Najmie Muhammad Yusuf
title Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
title_short Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
title_full Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
title_fullStr Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
title_full_unstemmed Hyperandrogenism and Its Possible Effects on Endometrial Receptivity: A Review
title_sort hyperandrogenism and its possible effects on endometrial receptivity: a review
publisher Molecular Diversity Preservation International (MDPI)
publishDate 2023
url https://eprints.ums.edu.my/id/eprint/37494/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/37494/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/37494/
https://doi.org/10.3390/ijms241512026
_version_ 1781705921848672256
score 13.211869

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