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Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress

Over 10% of the world population suffer from mental disorders. In particular, depression causes about 800,000 suicide cases annually, while anxiety is the most common mental disorder. Stresses from work, life, and health have been identified as the common triggers for the two mental disorders. Event...

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Main Authors: Wan Lei Thien, Chrystalle Bih Yuan Tan, Kai Ling Chin
Format: Article
Language:English
English
Published: Neurotak Publishing 2023
Subjects:
QP501-801 Animal biochemistry
RA1001-1171 Forensic medicine. Medical jurisprudence. Legal medicine
Online Access:https://eprints.ums.edu.my/id/eprint/37476/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/37476/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/37476/
https://doi.org/10.31117/neuroscirn.v6i2.215
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spelling my.ums.eprints.374762023-10-09T02:10:04Z https://eprints.ums.edu.my/id/eprint/37476/ Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress Wan Lei Thien Chrystalle Bih Yuan Tan Kai Ling Chin QP501-801 Animal biochemistry RA1001-1171 Forensic medicine. Medical jurisprudence. Legal medicine Over 10% of the world population suffer from mental disorders. In particular, depression causes about 800,000 suicide cases annually, while anxiety is the most common mental disorder. Stresses from work, life, and health have been identified as the common triggers for the two mental disorders. Eventhough mental disorders are treatable and validated tools are available to diagnose, many individuals are left untreated due to different factors, such as a lack of trained personnel and stigma. Neuroscience research indicates that mental disorders could be hereditary, where genes involved in determining behavioural variants. Disturbance in brain communication, resulting from abnormalities in neurogenesis, neurotransmission, and enzymatic degradation, have led to negative emotional states. This mini-review will highlight some important genes in the neurotransmitter systems and explore the relationship between gene polymorphisms and emotional states (i.e., depression, anxiety, and stress). The genes that will be discussed in this mini-review include brain-derived neurotrophic factor (BDNF) which is involved in neuron development, serotonin-transporter-linked polymorphic region (5-HTTLPR) and 5- hydroxytryptamine receptor 1A (5-HT1A) which are involved in serotonin neurotransmitter action potential propagation, and monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT), which are involved in neurotransmitter catabolism. Neurotak Publishing 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/37476/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/37476/2/FULL%20TEXT.pdf Wan Lei Thien and Chrystalle Bih Yuan Tan and Kai Ling Chin (2023) Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress. Neuroscience research notes, 6 (2). pp. 1-11. ISSN 2576-828X https://doi.org/10.31117/neuroscirn.v6i2.215
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QP501-801 Animal biochemistry
RA1001-1171 Forensic medicine. Medical jurisprudence. Legal medicine
spellingShingle QP501-801 Animal biochemistry
RA1001-1171 Forensic medicine. Medical jurisprudence. Legal medicine
Wan Lei Thien
Chrystalle Bih Yuan Tan
Kai Ling Chin
Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
description Over 10% of the world population suffer from mental disorders. In particular, depression causes about 800,000 suicide cases annually, while anxiety is the most common mental disorder. Stresses from work, life, and health have been identified as the common triggers for the two mental disorders. Eventhough mental disorders are treatable and validated tools are available to diagnose, many individuals are left untreated due to different factors, such as a lack of trained personnel and stigma. Neuroscience research indicates that mental disorders could be hereditary, where genes involved in determining behavioural variants. Disturbance in brain communication, resulting from abnormalities in neurogenesis, neurotransmission, and enzymatic degradation, have led to negative emotional states. This mini-review will highlight some important genes in the neurotransmitter systems and explore the relationship between gene polymorphisms and emotional states (i.e., depression, anxiety, and stress). The genes that will be discussed in this mini-review include brain-derived neurotrophic factor (BDNF) which is involved in neuron development, serotonin-transporter-linked polymorphic region (5-HTTLPR) and 5- hydroxytryptamine receptor 1A (5-HT1A) which are involved in serotonin neurotransmitter action potential propagation, and monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT), which are involved in neurotransmitter catabolism.
format Article
author Wan Lei Thien
Chrystalle Bih Yuan Tan
Kai Ling Chin
author_facet Wan Lei Thien
Chrystalle Bih Yuan Tan
Kai Ling Chin
author_sort Wan Lei Thien
title Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
title_short Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
title_full Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
title_fullStr Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
title_full_unstemmed Influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
title_sort influences of neurotransmission-related genetic polymorphisms on depression, anxiety and stress
publisher Neurotak Publishing
publishDate 2023
url https://eprints.ums.edu.my/id/eprint/37476/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/37476/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/37476/
https://doi.org/10.31117/neuroscirn.v6i2.215
_version_ 1781705919985352704
score 13.211869

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