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Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats

Background: Type 2 diabetes is one of the most common metabolic diseases in recent years and has become an important risk factor for cardiovascular disorders. The first goal is to reduce type 2 diabetes, and in the case of cardiovascular disease, the second goal is to reduce and manage that disorder...

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Main Authors: Mohammad Rami, Samane Rahdar, Amirhoseein Ahmadi Hekmatikar, D. Maryama Awang Daud
Format: Article
Language:English
English
Published: National Library of Medicine 2023
Subjects:
GV460-555 Gymnastics. Gymnastic exercises Including calisthenics, heavy exercises, acrobatics, etc.
RE91-912 Particular diseases of the eye
Online Access:https://eprints.ums.edu.my/id/eprint/36747/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/36747/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/36747/
https://doi.org/10.3389/fendo.2023.1175585
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spelling my.ums.eprints.367472023-09-06T07:42:23Z https://eprints.ums.edu.my/id/eprint/36747/ Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats Mohammad Rami Samane Rahdar Amirhoseein Ahmadi Hekmatikar D. Maryama Awang Daud GV460-555 Gymnastics. Gymnastic exercises Including calisthenics, heavy exercises, acrobatics, etc. RE91-912 Particular diseases of the eye Background: Type 2 diabetes is one of the most common metabolic diseases in recent years and has become an important risk factor for cardiovascular disorders. The first goal is to reduce type 2 diabetes, and in the case of cardiovascular disease, the second goal is to reduce and manage that disorder. Materials and methods: The rats were divided into 4 groups: Healthy Control (n=8), Diabetes Control (n=8), Diabetes Training (n=8), and Healthy Training (n=8). The protocol consisted of 8 weeks of High-intensity interval (5 sessions per week), where the training started with 80% of the peak speed in the first week, and 10% was added to this speed every week. To measure the level of B-catenin, c-MYC, GSK3B, and Bcl-2 proteins using the western blot method, cardiac pathological changes were measured using hematoxylin and eosin staining, Masson's trichrome and PAS staining and apoptosis using the TUNEL method. Findings: Histological results showed that diabetes causes significant pathological hypertrophy, fibrosis, and severe apoptosis in heart tissue. HIIT training significantly reduced pathological hypertrophy and fibrosis in heart tissue, and the rate of cardiomyocyte apoptosis was greatly reduced. This research showed that diabetes disorder increases the levels of B-catenin and c-Myc proteins and causes a decrease in the expression of GSK3B and Bcl-2 proteins. After eight weeks of HIIT training, the levels of B-catenin and c-Myc proteins decreased significantly, and the levels of GSK3B and Bcl-2 proteins increased. Conclusion: This study showed that HIIT could be a suitable strategy to reduce cardiomyopathy in type 2 diabetic rats. However, it is suggested that in future studies, researchers should perform different intensities and exercises to promote exercise goals in type 2 diabetic cardiomyopathy. National Library of Medicine 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36747/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36747/2/FULL%20TEXT.pdf Mohammad Rami and Samane Rahdar and Amirhoseein Ahmadi Hekmatikar and D. Maryama Awang Daud (2023) Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats. Frontiers. pp. 1-14. https://doi.org/10.3389/fendo.2023.1175585
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic GV460-555 Gymnastics. Gymnastic exercises Including calisthenics, heavy exercises, acrobatics, etc.
RE91-912 Particular diseases of the eye
spellingShingle GV460-555 Gymnastics. Gymnastic exercises Including calisthenics, heavy exercises, acrobatics, etc.
RE91-912 Particular diseases of the eye
Mohammad Rami
Samane Rahdar
Amirhoseein Ahmadi Hekmatikar
D. Maryama Awang Daud
Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
description Background: Type 2 diabetes is one of the most common metabolic diseases in recent years and has become an important risk factor for cardiovascular disorders. The first goal is to reduce type 2 diabetes, and in the case of cardiovascular disease, the second goal is to reduce and manage that disorder. Materials and methods: The rats were divided into 4 groups: Healthy Control (n=8), Diabetes Control (n=8), Diabetes Training (n=8), and Healthy Training (n=8). The protocol consisted of 8 weeks of High-intensity interval (5 sessions per week), where the training started with 80% of the peak speed in the first week, and 10% was added to this speed every week. To measure the level of B-catenin, c-MYC, GSK3B, and Bcl-2 proteins using the western blot method, cardiac pathological changes were measured using hematoxylin and eosin staining, Masson's trichrome and PAS staining and apoptosis using the TUNEL method. Findings: Histological results showed that diabetes causes significant pathological hypertrophy, fibrosis, and severe apoptosis in heart tissue. HIIT training significantly reduced pathological hypertrophy and fibrosis in heart tissue, and the rate of cardiomyocyte apoptosis was greatly reduced. This research showed that diabetes disorder increases the levels of B-catenin and c-Myc proteins and causes a decrease in the expression of GSK3B and Bcl-2 proteins. After eight weeks of HIIT training, the levels of B-catenin and c-Myc proteins decreased significantly, and the levels of GSK3B and Bcl-2 proteins increased. Conclusion: This study showed that HIIT could be a suitable strategy to reduce cardiomyopathy in type 2 diabetic rats. However, it is suggested that in future studies, researchers should perform different intensities and exercises to promote exercise goals in type 2 diabetic cardiomyopathy.
format Article
author Mohammad Rami
Samane Rahdar
Amirhoseein Ahmadi Hekmatikar
D. Maryama Awang Daud
author_facet Mohammad Rami
Samane Rahdar
Amirhoseein Ahmadi Hekmatikar
D. Maryama Awang Daud
author_sort Mohammad Rami
title Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
title_short Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
title_full Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
title_fullStr Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
title_full_unstemmed Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
title_sort highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats
publisher National Library of Medicine
publishDate 2023
url https://eprints.ums.edu.my/id/eprint/36747/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/36747/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/36747/
https://doi.org/10.3389/fendo.2023.1175585
_version_ 1778162792203812864
score 13.211869

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