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The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling

Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumor...

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Main Authors: Suhaini Sudi, Fiona Macniesia Thomas, Siti Kadzirah Daud, Dayang Maryama Ag Daud, Caroline Sunggip
Format: Article
Language:English
English
Published: Molecular Diversity Preservation International (MDPI) 2023
Subjects:
QP501-801 Animal biochemistry
RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
Online Access:https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/36288/
https://doi.org/10.3390/molecules28052102
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spelling my.ums.eprints.362882023-08-04T08:51:02Z https://eprints.ums.edu.my/id/eprint/36288/ The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling Suhaini Sudi Fiona Macniesia Thomas Siti Kadzirah Daud Dayang Maryama Ag Daud Caroline Sunggip QP501-801 Animal biochemistry RA643-645 Disease (Communicable and noninfectious) and public health RC31-1245 Internal medicine Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumoral factors and chronic stress, leading to heart failure. Adenosine triphosphate (ATP) is one of the potent mediators in cardiovascular signalling that act on the ligand-gated (P2X) and G-protein-coupled (P2Y) purinoceptors via the autocrine or paracrine manners. These activations mediate numerous intracellular communications by modulating the production of other messengers, including calcium, growth factors, cytokines, and nitric oxide. ATP is known to play a pleiotropic role in cardiovascular pathophysiology, making it a reliable biomarker for cardiac protection. This review outlines the sources of ATP released under physiological and pathological stress and its cell-specific mechanism of action. We further highlight a series of cardiovascular cell-to-cell communications of extracellular ATP signalling cascades in cardiac remodelling, which can be seen in hypertension, ischemia/reperfusion injury, fibrosis, hypertrophy, and atrophy. Finally, we summarize current pharmacological intervention using the ATP network as a target for cardiac protection. A better understanding of ATP communication in myocardial remodelling could be worthwhile for future drug development and repurposing and the management of cardiovascular diseases. Molecular Diversity Preservation International (MDPI) 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf Suhaini Sudi and Fiona Macniesia Thomas and Siti Kadzirah Daud and Dayang Maryama Ag Daud and Caroline Sunggip (2023) The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling. Molecules, 28. pp. 1-29. https://doi.org/10.3390/molecules28052102
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QP501-801 Animal biochemistry
RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
spellingShingle QP501-801 Animal biochemistry
RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
Suhaini Sudi
Fiona Macniesia Thomas
Siti Kadzirah Daud
Dayang Maryama Ag Daud
Caroline Sunggip
The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
description Myocardial remodelling is a molecular, cellular, and interstitial adaptation of the heart in response to altered environmental demands. The heart undergoes reversible physiological remodelling in response to changes in mechanical loading or irreversible pathological remodelling induced by neurohumoral factors and chronic stress, leading to heart failure. Adenosine triphosphate (ATP) is one of the potent mediators in cardiovascular signalling that act on the ligand-gated (P2X) and G-protein-coupled (P2Y) purinoceptors via the autocrine or paracrine manners. These activations mediate numerous intracellular communications by modulating the production of other messengers, including calcium, growth factors, cytokines, and nitric oxide. ATP is known to play a pleiotropic role in cardiovascular pathophysiology, making it a reliable biomarker for cardiac protection. This review outlines the sources of ATP released under physiological and pathological stress and its cell-specific mechanism of action. We further highlight a series of cardiovascular cell-to-cell communications of extracellular ATP signalling cascades in cardiac remodelling, which can be seen in hypertension, ischemia/reperfusion injury, fibrosis, hypertrophy, and atrophy. Finally, we summarize current pharmacological intervention using the ATP network as a target for cardiac protection. A better understanding of ATP communication in myocardial remodelling could be worthwhile for future drug development and repurposing and the management of cardiovascular diseases.
format Article
author Suhaini Sudi
Fiona Macniesia Thomas
Siti Kadzirah Daud
Dayang Maryama Ag Daud
Caroline Sunggip
author_facet Suhaini Sudi
Fiona Macniesia Thomas
Siti Kadzirah Daud
Dayang Maryama Ag Daud
Caroline Sunggip
author_sort Suhaini Sudi
title The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
title_short The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
title_full The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
title_fullStr The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
title_full_unstemmed The Pleiotropic Role of Extracellular ATP in Myocardial Remodelling
title_sort pleiotropic role of extracellular atp in myocardial remodelling
publisher Molecular Diversity Preservation International (MDPI)
publishDate 2023
url https://eprints.ums.edu.my/id/eprint/36288/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/36288/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/36288/
https://doi.org/10.3390/molecules28052102
_version_ 1773544863692750848
score 13.211869

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