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A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer

Breast cancer incidence and mortality rates have increased exponentially during the last decade, particularly among female patients. Current therapies, including surgery and chemotherapy, have significant negative physical and mental impacts on patients. As a safer alternative, gene therapy utilisin...

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Main Authors: Gloria Yi Wei Tseu, Khairul Azfar Kamaruzaman
Format: Article
Language:English
English
Published: Molecular Diversity Preservation International (MDPI) 2022
Subjects:
RB151-214 Theories of disease. Etiology. Pathogenesis
RS200-201 Pharmaceutical dosage forms
Online Access:https://eprints.ums.edu.my/id/eprint/35794/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/35794/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/35794/
https://doi.org/10.3390/molecules28031498
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spelling my.ums.eprints.357942023-07-07T06:28:39Z https://eprints.ums.edu.my/id/eprint/35794/ A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer Gloria Yi Wei Tseu Khairul Azfar Kamaruzaman RB151-214 Theories of disease. Etiology. Pathogenesis RS200-201 Pharmaceutical dosage forms Breast cancer incidence and mortality rates have increased exponentially during the last decade, particularly among female patients. Current therapies, including surgery and chemotherapy, have significant negative physical and mental impacts on patients. As a safer alternative, gene therapy utilising a therapeutic gene with the potential to treat various ailments is being considered. Delivery of the gene generally utilises viral vectors. However, immunological reactions and even mortality have been recorded as side effects. As a result, non-viral vectors, such as liposomes, a system composed of lipid bilayers formed into nanoparticles, are being studied. Liposomes have demonstrated tremendous potential due to their limitless ability to combine many functions into a system with desirable characteristics and functionality. This article discusses cationic, anionic, and neutral liposomes with their stability, cytotoxicity, transfection ability, cellular uptake, and limitation as a gene carrier suitable for gene therapy specifically for cancer. Due to the more practical approach of employing electrostatic contact with the negatively charged nucleic acid and the cell membrane for absorption purposes, cationic liposomes appear to be more suited for formulation for gene delivery and therapy for breast cancer treatment. As the other alternatives have numerous complicated additional modifications, attachments need to be made to achieve a functional gene therapy system for breast cancer treatment, which were also discussed in this review. This review aimed to increase understanding and build a viable breast cancer gene therapy treatment strategy. Molecular Diversity Preservation International (MDPI) 2022 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/35794/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/35794/2/FULL%20TEXT.pdf Gloria Yi Wei Tseu and Khairul Azfar Kamaruzaman (2022) A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer. Molecules, 28. pp. 1-31. https://doi.org/10.3390/molecules28031498
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RB151-214 Theories of disease. Etiology. Pathogenesis
RS200-201 Pharmaceutical dosage forms
spellingShingle RB151-214 Theories of disease. Etiology. Pathogenesis
RS200-201 Pharmaceutical dosage forms
Gloria Yi Wei Tseu
Khairul Azfar Kamaruzaman
A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
description Breast cancer incidence and mortality rates have increased exponentially during the last decade, particularly among female patients. Current therapies, including surgery and chemotherapy, have significant negative physical and mental impacts on patients. As a safer alternative, gene therapy utilising a therapeutic gene with the potential to treat various ailments is being considered. Delivery of the gene generally utilises viral vectors. However, immunological reactions and even mortality have been recorded as side effects. As a result, non-viral vectors, such as liposomes, a system composed of lipid bilayers formed into nanoparticles, are being studied. Liposomes have demonstrated tremendous potential due to their limitless ability to combine many functions into a system with desirable characteristics and functionality. This article discusses cationic, anionic, and neutral liposomes with their stability, cytotoxicity, transfection ability, cellular uptake, and limitation as a gene carrier suitable for gene therapy specifically for cancer. Due to the more practical approach of employing electrostatic contact with the negatively charged nucleic acid and the cell membrane for absorption purposes, cationic liposomes appear to be more suited for formulation for gene delivery and therapy for breast cancer treatment. As the other alternatives have numerous complicated additional modifications, attachments need to be made to achieve a functional gene therapy system for breast cancer treatment, which were also discussed in this review. This review aimed to increase understanding and build a viable breast cancer gene therapy treatment strategy.
format Article
author Gloria Yi Wei Tseu
Khairul Azfar Kamaruzaman
author_facet Gloria Yi Wei Tseu
Khairul Azfar Kamaruzaman
author_sort Gloria Yi Wei Tseu
title A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
title_short A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
title_full A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
title_fullStr A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
title_full_unstemmed A Review of Different Types of Liposomes and Their Advancements as a Form of Gene Therapy Treatment for Breast Cancer
title_sort review of different types of liposomes and their advancements as a form of gene therapy treatment for breast cancer
publisher Molecular Diversity Preservation International (MDPI)
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/35794/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/35794/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/35794/
https://doi.org/10.3390/molecules28031498
_version_ 1772812699983413248
score 13.211869

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