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Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University

Relative leptin resistance in childhood to absolute leptin resistance in maturity suggests sleep, eating behaviour, and the psychological state as probable causes. The current body of research provides inconclusive evidence linking G2548A and Q223R to obesity. Furthermore, we could find very little...

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Main Authors: Jaiprakash Mohanraj, Urban J. A. D’Souza, Siat Yee Fong, Ivan Rolland Karkada, Heethal Jaiprakash
Format: Article
Language:English
English
Published: Molecular Diversity Preservation International (MDPI) 2022
Subjects:
QP501-801 Animal biochemistry
RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Online Access:https://eprints.ums.edu.my/id/eprint/35755/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/35755/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/35755/
https://doi.org/10.3390/ijerph19148862
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spelling my.ums.eprints.357552023-06-30T01:36:52Z https://eprints.ums.edu.my/id/eprint/35755/ Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University Jaiprakash Mohanraj Urban J. A. D’Souza Siat Yee Fong Ivan Rolland Karkada Heethal Jaiprakash QP501-801 Animal biochemistry RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens Relative leptin resistance in childhood to absolute leptin resistance in maturity suggests sleep, eating behaviour, and the psychological state as probable causes. The current body of research provides inconclusive evidence linking G2548A and Q223R to obesity. Furthermore, we could find very little data that have observed the association between the environment and gene polymorphism, especially in the multiethnic population that exists in Malaysia. This study searched for a possible link between sleeping habits, eating behaviour, and stress indicators with plasma leptin and its genetic variation in young adult Malaysian healthcare students. The study involved 185 first- and second-year medical and dental students from a healthcare university. Polymerase Chain Reaction– Restriction Fragment Length Polymorphism(PCR-RFLP) determined the genotype, Enzyme Linked Immunoabsorbant Assay (ELISA) tested the serum leptin, and a self-administered questionnaire evaluated sleep, eating behaviour, and psychological condition. Gender and ethnicity are linked to fasting plasma leptin levels (p < 0.001). Plasma leptin also affects stress, anxiety, and sadness. Leptin (LEP) and Leptin Receptor (LEPR) polymorphisms were not associated with BMI, plasma leptin, sleep, eating behaviour, or psychological state. Young adult Malaysian Indians were obese and overweight, while Chinese were underweight. These findings imply overweight and obese participants were in stage I of leptin resistance and lifestyle change or leptin therapy could prevent them from becoming cripplingly obese as they age Molecular Diversity Preservation International (MDPI) 2022 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/35755/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/35755/2/FULL%20TEXT.pdf Jaiprakash Mohanraj and Urban J. A. D’Souza and Siat Yee Fong and Ivan Rolland Karkada and Heethal Jaiprakash (2022) Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University. International Journal of Environmental Research and Public Health, 19. pp. 1-17. https://doi.org/10.3390/ijerph19148862
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic QP501-801 Animal biochemistry
RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
spellingShingle QP501-801 Animal biochemistry
RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Jaiprakash Mohanraj
Urban J. A. D’Souza
Siat Yee Fong
Ivan Rolland Karkada
Heethal Jaiprakash
Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
description Relative leptin resistance in childhood to absolute leptin resistance in maturity suggests sleep, eating behaviour, and the psychological state as probable causes. The current body of research provides inconclusive evidence linking G2548A and Q223R to obesity. Furthermore, we could find very little data that have observed the association between the environment and gene polymorphism, especially in the multiethnic population that exists in Malaysia. This study searched for a possible link between sleeping habits, eating behaviour, and stress indicators with plasma leptin and its genetic variation in young adult Malaysian healthcare students. The study involved 185 first- and second-year medical and dental students from a healthcare university. Polymerase Chain Reaction– Restriction Fragment Length Polymorphism(PCR-RFLP) determined the genotype, Enzyme Linked Immunoabsorbant Assay (ELISA) tested the serum leptin, and a self-administered questionnaire evaluated sleep, eating behaviour, and psychological condition. Gender and ethnicity are linked to fasting plasma leptin levels (p < 0.001). Plasma leptin also affects stress, anxiety, and sadness. Leptin (LEP) and Leptin Receptor (LEPR) polymorphisms were not associated with BMI, plasma leptin, sleep, eating behaviour, or psychological state. Young adult Malaysian Indians were obese and overweight, while Chinese were underweight. These findings imply overweight and obese participants were in stage I of leptin resistance and lifestyle change or leptin therapy could prevent them from becoming cripplingly obese as they age
format Article
author Jaiprakash Mohanraj
Urban J. A. D’Souza
Siat Yee Fong
Ivan Rolland Karkada
Heethal Jaiprakash
author_facet Jaiprakash Mohanraj
Urban J. A. D’Souza
Siat Yee Fong
Ivan Rolland Karkada
Heethal Jaiprakash
author_sort Jaiprakash Mohanraj
title Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
title_short Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
title_full Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
title_fullStr Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
title_full_unstemmed Association between Leptin (G2548A) and Leptin Receptor (Q223R) polymorphisms with Plasma Leptin, BMI, Stress, Sleep and Eating Patterns among the Multiethnic Young Malaysian Adult Population from a Healthcare University
title_sort association between leptin (g2548a) and leptin receptor (q223r) polymorphisms with plasma leptin, bmi, stress, sleep and eating patterns among the multiethnic young malaysian adult population from a healthcare university
publisher Molecular Diversity Preservation International (MDPI)
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/35755/1/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/35755/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/35755/
https://doi.org/10.3390/ijerph19148862
_version_ 1770552500340916224
score 13.211869

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