Staff View: Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties

Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties

Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to...

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Main Authors:	How, See Choon, Poh, Lucky Wah Goh, Norhaniza Johansah, Azlinah Matawali, Jualang Azlan Gansau, How, Siew Eng
Format:	Article
Language:	English English
Published:	Acta Scientiarum. Technology 2022
Subjects:	QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine
Online Access:	https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf https://eprints.ums.edu.my/id/eprint/34992/ https://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/56879 https://doi.org/10.4025/actascitechnol.v44i1.56879
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spelling	my.ums.eprints.349922022-12-05T00:06:10Z https://eprints.ums.edu.my/id/eprint/34992/ Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to inhibit the key enzymes involved in obesity, hyperglycemia and oxidative stress. A total of 46 plant extracts were subjected to anti-pancreatic lipase, α-amylase inhibition and antioxidant assays. It was observed that S43 (Lantana camara) exhibited the greatest IC50 of anti-pancreatic lipase activity (mean of IC50 (±S.D.) = 0.20 mg mL-1 ± 0.010). Cinnamomum sp. (S42) has the most substantial α-amylase activity with a mean IC50 (±S.D.) = 2.68 mg mL-1 ± 0.471. S19 (Glochidion rubrum) was the most effective antioxidants (mean of IC50 (±S.D.) = 0.011 mg mL-1 ± 0.004) among all the investigated samples. Interestingly, three plant extracts were found (S6-Buchanania sp.; S22-Vitex negundo and S42-Cinnamomum sp.) to exhibit inhibition activity in ant pancreatic lipase, α-amylase and antioxidant assays. The bioactivities of plant extracts have been closely related to the content of phytochemicals, as in earlier studies. Thus, plants have the potential to serve as supplements and nutraceuticals for obesity and other related complications. Acta Scientiarum. Technology 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf text en https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf How, See Choon and Poh, Lucky Wah Goh and Norhaniza Johansah and Azlinah Matawali and Jualang Azlan Gansau and How, Siew Eng (2022) Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties. Acta Scientiarum. Technology, 44. pp. 1-13. ISSN 1806-2563 (P-ISSN) , 1807-8664 (E-ISSN) https://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/56879 https://doi.org/10.4025/actascitechnol.v44i1.56879
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine
spellingShingle	QK1-989 Botany RV1-431 Botanic, Thomsonian, and eclectic medicine How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
description	Medicinal plants have been widely used for their notable health benefits and help in disease prevention for generations. In recent years, obesity has become among the risk factors of hyperglycemia and oxidation stress. This study aims to investigate the potential of plants in Sabah, North Borneo to inhibit the key enzymes involved in obesity, hyperglycemia and oxidative stress. A total of 46 plant extracts were subjected to anti-pancreatic lipase, α-amylase inhibition and antioxidant assays. It was observed that S43 (Lantana camara) exhibited the greatest IC50 of anti-pancreatic lipase activity (mean of IC50 (±S.D.) = 0.20 mg mL-1 ± 0.010). Cinnamomum sp. (S42) has the most substantial α-amylase activity with a mean IC50 (±S.D.) = 2.68 mg mL-1 ± 0.471. S19 (Glochidion rubrum) was the most effective antioxidants (mean of IC50 (±S.D.) = 0.011 mg mL-1 ± 0.004) among all the investigated samples. Interestingly, three plant extracts were found (S6-Buchanania sp.; S22-Vitex negundo and S42-Cinnamomum sp.) to exhibit inhibition activity in ant pancreatic lipase, α-amylase and antioxidant assays. The bioactivities of plant extracts have been closely related to the content of phytochemicals, as in earlier studies. Thus, plants have the potential to serve as supplements and nutraceuticals for obesity and other related complications.
format	Article
author	How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng
author_facet	How, See Choon Poh, Lucky Wah Goh Norhaniza Johansah Azlinah Matawali Jualang Azlan Gansau How, Siew Eng
author_sort	How, See Choon
title	Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
title_short	Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
title_full	Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
title_fullStr	Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
title_full_unstemmed	Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
title_sort	medicinal plants in sabah (north borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties
publisher	Acta Scientiarum. Technology
publishDate	2022
url	https://eprints.ums.edu.my/id/eprint/34992/1/Abstract.pdf https://eprints.ums.edu.my/id/eprint/34992/2/Full%20text.pdf https://eprints.ums.edu.my/id/eprint/34992/ https://periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/56879 https://doi.org/10.4025/actascitechnol.v44i1.56879
_version_	1760231369524379648
score	13.211869

Medicinal plants in Sabah (North Borneo) exhibit antipancreatic lipase, anti-amylase, and antioxidant properties

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