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Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials

Polycystic ovary syndrome (PCOS) and endometriosis are reproductive disorders that may cause infertility. The pathology of both diseases has been suggested to be associated with sex steroid hormone receptors, including estrogen receptors (ER), progesterone receptors (PRs) and androgen receptors (ARs...

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Main Authors: Fazilah Abdul Hamid, Muhammad Azrai Abu, Abdul Kadir Abdul Karim, Mohd Faizal Ahmad, Nor Haslinda Abd. Aziz, Datu Agasi Mohd Kamal, Mohd Helmy Mokhtar
Format: Article
Language:English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2022
Subjects:
RG484-485 Urogynecology and obstetric urology. Urogynecologic surgery
Online Access:https://eprints.ums.edu.my/id/eprint/34591/1/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34591/2/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/34591/
https://www.mdpi.com/2227-9059/10/7/1705/htm
https://doi.org/10.3390/biomedicines10071705
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spelling my.ums.eprints.345912022-11-02T00:40:04Z https://eprints.ums.edu.my/id/eprint/34591/ Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials Fazilah Abdul Hamid Muhammad Azrai Abu Abdul Kadir Abdul Karim Mohd Faizal Ahmad Nor Haslinda Abd. Aziz Datu Agasi Mohd Kamal Mohd Helmy Mokhtar RG484-485 Urogynecology and obstetric urology. Urogynecologic surgery Polycystic ovary syndrome (PCOS) and endometriosis are reproductive disorders that may cause infertility. The pathology of both diseases has been suggested to be associated with sex steroid hormone receptors, including estrogen receptors (ER), progesterone receptors (PRs) and androgen receptors (ARs). Therefore, with this review, we aim to provide an update on the available knowledge of these receptors and how their interactions contribute to the pathogenesis of PCOS and endometriosis. One of the main PCOS-related medical conditions is abnormal folliculo genesis, which is associated with the downregulation of ER and AR expression in the ovaries. In addition, metabolic disorders in PCOS are caused by dysregulation of sex steroid hormone receptor expression. Furthermore, endometriosis is related to the upregulation of ER and the downregulation of PR expression. These receptors may serve as therapeutic targets for the treatment of PCOS-related disorders and endometriosis, considering their pathophysiological roles. Receptor agonists maybe applied to increase the expression of a specific receptor and treat endometriosis or metabolic disorders. In contrast, receptor antagonist functions to reduce receptor expression and can be used to treat endometriosis and induce ovulation. Understanding PCOS and the pathological roles of endometriosis sex steroid receptors is crucial for developing potential therapeutic strategies to treat infertility in both conditions. Therefore, research should be continued to fill the knowledge gap regarding the subject. Multidisciplinary Digital Publishing Institute (MDPI) 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/34591/1/FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/34591/2/ABSTRACT.pdf Fazilah Abdul Hamid and Muhammad Azrai Abu and Abdul Kadir Abdul Karim and Mohd Faizal Ahmad and Nor Haslinda Abd. Aziz and Datu Agasi Mohd Kamal and Mohd Helmy Mokhtar (2022) Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials. Biomedicines, 10 (1705). pp. 1-21. ISSN 2227-9059 https://www.mdpi.com/2227-9059/10/7/1705/htm https://doi.org/10.3390/biomedicines10071705
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RG484-485 Urogynecology and obstetric urology. Urogynecologic surgery
spellingShingle RG484-485 Urogynecology and obstetric urology. Urogynecologic surgery
Fazilah Abdul Hamid
Muhammad Azrai Abu
Abdul Kadir Abdul Karim
Mohd Faizal Ahmad
Nor Haslinda Abd. Aziz
Datu Agasi Mohd Kamal
Mohd Helmy Mokhtar
Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
description Polycystic ovary syndrome (PCOS) and endometriosis are reproductive disorders that may cause infertility. The pathology of both diseases has been suggested to be associated with sex steroid hormone receptors, including estrogen receptors (ER), progesterone receptors (PRs) and androgen receptors (ARs). Therefore, with this review, we aim to provide an update on the available knowledge of these receptors and how their interactions contribute to the pathogenesis of PCOS and endometriosis. One of the main PCOS-related medical conditions is abnormal folliculo genesis, which is associated with the downregulation of ER and AR expression in the ovaries. In addition, metabolic disorders in PCOS are caused by dysregulation of sex steroid hormone receptor expression. Furthermore, endometriosis is related to the upregulation of ER and the downregulation of PR expression. These receptors may serve as therapeutic targets for the treatment of PCOS-related disorders and endometriosis, considering their pathophysiological roles. Receptor agonists maybe applied to increase the expression of a specific receptor and treat endometriosis or metabolic disorders. In contrast, receptor antagonist functions to reduce receptor expression and can be used to treat endometriosis and induce ovulation. Understanding PCOS and the pathological roles of endometriosis sex steroid receptors is crucial for developing potential therapeutic strategies to treat infertility in both conditions. Therefore, research should be continued to fill the knowledge gap regarding the subject.
format Article
author Fazilah Abdul Hamid
Muhammad Azrai Abu
Abdul Kadir Abdul Karim
Mohd Faizal Ahmad
Nor Haslinda Abd. Aziz
Datu Agasi Mohd Kamal
Mohd Helmy Mokhtar
author_facet Fazilah Abdul Hamid
Muhammad Azrai Abu
Abdul Kadir Abdul Karim
Mohd Faizal Ahmad
Nor Haslinda Abd. Aziz
Datu Agasi Mohd Kamal
Mohd Helmy Mokhtar
author_sort Fazilah Abdul Hamid
title Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
title_short Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
title_full Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
title_fullStr Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
title_full_unstemmed Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials
title_sort sex steroid receptors in polycystic ovary syndrome and endometriosis: insights from laboratory studies to clinical trials
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/34591/1/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34591/2/ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/34591/
https://www.mdpi.com/2227-9059/10/7/1705/htm
https://doi.org/10.3390/biomedicines10071705
_version_ 1760231316158152704
score 13.211869

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