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Bioactive peptides and its alternative processes: A review

Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensinconverting enzyme inhibitors, antioxidants, opioids, and antimicrobials. Howe...

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Main Authors:	Norfahana Abd-Talib, Emmy Liza Anak Yaji, Nur Suraya Abd Wahab, Nadia Razali, Kelly Yong Tau Len, Jumardi Roslan, Nazamid Saari, Khairul Faizal Pa’ee
Format:	Article
Language:	English English
Published:	Universiti Malaysia Sabah 2022
Subjects:	QP501-801 Animal biochemistry TP248.13-248.65 Biotechnology
Online Access:	https://eprints.ums.edu.my/id/eprint/33150/1/Bioactive%20peptides%20and%20its%20alternative%20processes%2C%20A%20review.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/33150/2/Bioactive%20Peptides%20and%20Its%20Alternative%20Processes%2C%20A%20Review.pdf https://eprints.ums.edu.my/id/eprint/33150/ https://link.springer.com/article/10.1007/s12257-021-0160-8 https://doi.org/10.1007/s12257-021-0160-8
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spelling	my.ums.eprints.331502022-07-20T03:55:41Z https://eprints.ums.edu.my/id/eprint/33150/ Bioactive peptides and its alternative processes: A review Norfahana Abd-Talib Emmy Liza Anak Yaji Nur Suraya Abd Wahab Nadia Razali Kelly Yong Tau Len Jumardi Roslan Nazamid Saari Khairul Faizal Pa’ee QP501-801 Animal biochemistry TP248.13-248.65 Biotechnology Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensinconverting enzyme inhibitors, antioxidants, opioids, and antimicrobials. However, various challenges hindered the industrial-scale production of peptides, such as the sensory performance of peptides due to bitterness, low peptides bioavailability and yield, minimal human tests, unconfirmed molecular mechanisms, and the sustainability of the resources for mass production. The emerging alternative processes such as high hydrostatic pressure, microwave, ultrasound, sub- and supercritical fluids are selectively beneficial, albeit time-consuming and expensive. The diversity of the properties of bioactive peptides complicates the design of the appropriate purification steps, particularly for novel peptides. The integrative process by coupling the production and purification of bioactive peptides to a single integrative system can be a way forward for bioactive peptides production with high purity, potency, and cost-effectiveness. Thus, the review provides a comprehensive insight into the current status, trends, and challenges of bioactive peptide production through conventional and emerging processes. Universiti Malaysia Sabah 2022-06-15 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/33150/1/Bioactive%20peptides%20and%20its%20alternative%20processes%2C%20A%20review.ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/33150/2/Bioactive%20Peptides%20and%20Its%20Alternative%20Processes%2C%20A%20Review.pdf Norfahana Abd-Talib and Emmy Liza Anak Yaji and Nur Suraya Abd Wahab and Nadia Razali and Kelly Yong Tau Len and Jumardi Roslan and Nazamid Saari and Khairul Faizal Pa’ee (2022) Bioactive peptides and its alternative processes: A review. Biotechnology and Bioprocess Engineering, 27. pp. 306-335. ISSN 1226-8372 (P-ISSN) , 1976-3816 (E-ISSN) https://link.springer.com/article/10.1007/s12257-021-0160-8 https://doi.org/10.1007/s12257-021-0160-8
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	QP501-801 Animal biochemistry TP248.13-248.65 Biotechnology
spellingShingle	QP501-801 Animal biochemistry TP248.13-248.65 Biotechnology Norfahana Abd-Talib Emmy Liza Anak Yaji Nur Suraya Abd Wahab Nadia Razali Kelly Yong Tau Len Jumardi Roslan Nazamid Saari Khairul Faizal Pa’ee Bioactive peptides and its alternative processes: A review
description	Bioactive peptides are molecules of paramount importance with significant health benefits. These bioactive peptides extracted from various food sources demonstrated significant bioactivity and potency, including angiotensinconverting enzyme inhibitors, antioxidants, opioids, and antimicrobials. However, various challenges hindered the industrial-scale production of peptides, such as the sensory performance of peptides due to bitterness, low peptides bioavailability and yield, minimal human tests, unconfirmed molecular mechanisms, and the sustainability of the resources for mass production. The emerging alternative processes such as high hydrostatic pressure, microwave, ultrasound, sub- and supercritical fluids are selectively beneficial, albeit time-consuming and expensive. The diversity of the properties of bioactive peptides complicates the design of the appropriate purification steps, particularly for novel peptides. The integrative process by coupling the production and purification of bioactive peptides to a single integrative system can be a way forward for bioactive peptides production with high purity, potency, and cost-effectiveness. Thus, the review provides a comprehensive insight into the current status, trends, and challenges of bioactive peptide production through conventional and emerging processes.
format	Article
author	Norfahana Abd-Talib Emmy Liza Anak Yaji Nur Suraya Abd Wahab Nadia Razali Kelly Yong Tau Len Jumardi Roslan Nazamid Saari Khairul Faizal Pa’ee
author_facet	Norfahana Abd-Talib Emmy Liza Anak Yaji Nur Suraya Abd Wahab Nadia Razali Kelly Yong Tau Len Jumardi Roslan Nazamid Saari Khairul Faizal Pa’ee
author_sort	Norfahana Abd-Talib
title	Bioactive peptides and its alternative processes: A review
title_short	Bioactive peptides and its alternative processes: A review
title_full	Bioactive peptides and its alternative processes: A review
title_fullStr	Bioactive peptides and its alternative processes: A review
title_full_unstemmed	Bioactive peptides and its alternative processes: A review
title_sort	bioactive peptides and its alternative processes: a review
publisher	Universiti Malaysia Sabah
publishDate	2022
url	https://eprints.ums.edu.my/id/eprint/33150/1/Bioactive%20peptides%20and%20its%20alternative%20processes%2C%20A%20review.ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/33150/2/Bioactive%20Peptides%20and%20Its%20Alternative%20Processes%2C%20A%20Review.pdf https://eprints.ums.edu.my/id/eprint/33150/ https://link.springer.com/article/10.1007/s12257-021-0160-8 https://doi.org/10.1007/s12257-021-0160-8
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score	13.211869

Bioactive peptides and its alternative processes: A review

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