Staff View: Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi

Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi

Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in...

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Main Authors:	Raimalynah Abd Razak, Meiny Suzery, Rafida Razali, Zarina Amin, Ruzaidi Azli Mohd Mokhtar, Lee, Ping Chin, Cahyo Budiman
Format:	Article
Language:	English English
Published:	Elsevier Inc. 2021
Subjects:	RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:	https://eprints.ums.edu.my/id/eprint/32839/1/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi.pdf https://eprints.ums.edu.my/id/eprint/32839/2/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi2.pdf https://eprints.ums.edu.my/id/eprint/32839/ https://www.sciencedirect.com/science/article/pii/S2352340921008635 https://doi.org/10.1016/j.dib.2021.107588
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spelling	my.ums.eprints.328392022-06-16T08:26:02Z https://eprints.ums.edu.my/id/eprint/32839/ Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Lee, Ping Chin Cahyo Budiman RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in the protein homeostasis molecular machinery and therefore be lethal for the parasite. While plants are considered excellent sources of bioactive compounds exhibiting inhibition activity towards Pk-ClpP, many local medicinal plants remain unexplored. This article expands the data collected from the inhibition properties of the methanolic extract of Asystasia gangetica (Chinese Violet), Alstonia scholaris (Pulai Tree), Piper retrofractum (Javanese Long Pepper) and Small anthus sonchifolius (Yacon) towards Pk-ClpP. These plants are widely found in Malaysia and Indonesia and have been traditionally used in various medical treatments. The present dataset showed that the extracts contained phenolic and flavonoid compounds in various concentrations, whereby S. sonchifolius was found to have the lowest content of phenolic and flavonoid contents, while A. gangetica and A. scholaris were statistically comparable, yet higher than P. retrofactum and S. sonchifolus. Further inhibition data assay towards Pk-ClpP revealed that A. gangetica, A. scholaris and P. retrofactum demonstrated remarkable inhibition activity with IC50 values of 39.06 ± 1.98, 48.92 ± 1.52, and 87.63 ± 3.55, respectively. However, the inhibition activity of these extracts was significantly lower than a serine protease inhibitor of phenylmethylsulfonyl fluoridenone (PMSF). Meanwhile, S. sonchifolus did not exhibit significant inhibition activity towards Pk-ClpP. In addition, Pk-ClpP was not inhibited by a cysteine protease inhibitor of E64 Elsevier Inc. 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32839/1/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi.pdf text en https://eprints.ums.edu.my/id/eprint/32839/2/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi2.pdf Raimalynah Abd Razak and Meiny Suzery and Rafida Razali and Zarina Amin and Ruzaidi Azli Mohd Mokhtar and Lee, Ping Chin and Cahyo Budiman (2021) Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi. Data in Brief, 39 (107588). pp. 1-8. ISSN 2352-3409 https://www.sciencedirect.com/science/article/pii/S2352340921008635 https://doi.org/10.1016/j.dib.2021.107588
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English English
topic	RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle	RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Lee, Ping Chin Cahyo Budiman Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
description	Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P. knowlesi malaria infection in Malaysia and Southeast Asian region. Inhibition of this system leads to a disruption in the protein homeostasis molecular machinery and therefore be lethal for the parasite. While plants are considered excellent sources of bioactive compounds exhibiting inhibition activity towards Pk-ClpP, many local medicinal plants remain unexplored. This article expands the data collected from the inhibition properties of the methanolic extract of Asystasia gangetica (Chinese Violet), Alstonia scholaris (Pulai Tree), Piper retrofractum (Javanese Long Pepper) and Small anthus sonchifolius (Yacon) towards Pk-ClpP. These plants are widely found in Malaysia and Indonesia and have been traditionally used in various medical treatments. The present dataset showed that the extracts contained phenolic and flavonoid compounds in various concentrations, whereby S. sonchifolius was found to have the lowest content of phenolic and flavonoid contents, while A. gangetica and A. scholaris were statistically comparable, yet higher than P. retrofactum and S. sonchifolus. Further inhibition data assay towards Pk-ClpP revealed that A. gangetica, A. scholaris and P. retrofactum demonstrated remarkable inhibition activity with IC50 values of 39.06 ± 1.98, 48.92 ± 1.52, and 87.63 ± 3.55, respectively. However, the inhibition activity of these extracts was significantly lower than a serine protease inhibitor of phenylmethylsulfonyl fluoridenone (PMSF). Meanwhile, S. sonchifolus did not exhibit significant inhibition activity towards Pk-ClpP. In addition, Pk-ClpP was not inhibited by a cysteine protease inhibitor of E64
format	Article
author	Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Lee, Ping Chin Cahyo Budiman
author_facet	Raimalynah Abd Razak Meiny Suzery Rafida Razali Zarina Amin Ruzaidi Azli Mohd Mokhtar Lee, Ping Chin Cahyo Budiman
author_sort	Raimalynah Abd Razak
title	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_short	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_full	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_fullStr	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_full_unstemmed	Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi
title_sort	technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of plasmodium knowlesi
publisher	Elsevier Inc.
publishDate	2021
url	https://eprints.ums.edu.my/id/eprint/32839/1/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi.pdf https://eprints.ums.edu.my/id/eprint/32839/2/Technical%20data%20on%20the%20inhibition%20properties%20of%20some%20medicinal%20plant%20extracts%20towards%20caseinolytic%20protease%20proteolytic%20subunit%20of%20Plasmodium%20knowlesi2.pdf https://eprints.ums.edu.my/id/eprint/32839/ https://www.sciencedirect.com/science/article/pii/S2352340921008635 https://doi.org/10.1016/j.dib.2021.107588
_version_	1760231081548709888
score	13.211869

Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi

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