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A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach

Introduction. Landscape changes disrupt environmental, social and biological systems, altering pathogen spillover and transmission risks. This study aims to quantify the impact of specific land management practices on spillover and transmission rates of zoonotic and vector-borne diseases within Mala...

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Main Authors: Kimberly Fornace, Benny Obrain Manin, Jason Matthiopoulos, Heather M Ferguson, Chris Drakeley, Kamruddin Ahmed, Koay, Teng Khoon, Robert M Ewers, Sylvia Daim, Tock, Hing Chua
Format: Article
Language:English
English
Published: Wellcome 2022
Subjects:
RC109-216 Infectious and parasitic diseases
RC31-1245 Internal medicine
Online Access:https://eprints.ums.edu.my/id/eprint/32810/1/A%20protocol%20for%20a%20longitudinal%2C%20observational%20cohort%20study%20of%20infection%20and%20exposure%20to%20zoonotic%20and%20vector-borne%20diseases%20across%20a%20land-use%20gradient%20in%20Sabah%2C%20Malaysian%20Borneo.pdf
https://eprints.ums.edu.my/id/eprint/32810/3/Wellcome%20Open%20Research.pdf
https://eprints.ums.edu.my/id/eprint/32810/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886174/pdf/wellcomeopenres-7-19556.pdf
https://doi.org/10.12688/wellcomeopenres.17678.1
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spelling my.ums.eprints.328102022-06-16T07:20:02Z https://eprints.ums.edu.my/id/eprint/32810/ A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach Kimberly Fornace Benny Obrain Manin Jason Matthiopoulos Heather M Ferguson Chris Drakeley Kamruddin Ahmed Koay, Teng Khoon Robert M Ewers Sylvia Daim Tock, Hing Chua RC109-216 Infectious and parasitic diseases RC31-1245 Internal medicine Introduction. Landscape changes disrupt environmental, social and biological systems, altering pathogen spillover and transmission risks. This study aims to quantify the impact of specific land management practices on spillover and transmission rates of zoonotic and vector-borne diseases within Malaysian Borneo. This protocol describes a cohort study with integrated ecological sampling to assess how deforestation and agricultural practices impact pathogen flow from wildlife and vector populations to human infection and detection by health facilities. This will focus on malaria, dengue and emerging arboviruses (Chikungunya and Zika), vector-borne diseases with varying contributions of simian reservoirs within this setting. Methods. A prospective longitudinal observational cohort study will be established in communities residing or working within the vicinity of the Stability of Altered Forest Ecosystems (SAFE) Project, a landscape gradient within Malaysian Borneo encompassing different plantation and forest types. The primary outcome of this study will be transmission intensity of selected zoonotic and vector-borne diseases, as quantified by changes in pathogen-specific antibody levels. Exposure will be measured using paired population-based serological surveys conducted at the beginning and end of the two-year cohort study. Secondary outcomes will include the distribution and infection rates of Aedes and Anopheles mosquito vectors, human risk behaviours and clinical cases reported to health facilities. Longitudinal data on human behaviour, contact with wildlife and GPS tracking of mobility patterns will be collected throughout the study period. This will be integrated with entomological surveillance to monitor densities and pathogen infection rates of Aedes and Anopheles mosquitoes relative to land cover. Within surrounding health clinics, continuous health facility surveillance will be used to monitor reported infections and febrile illnesses. Models will be developed to assess spillover and transmission rates relative to specific land management practices and evaluate abilities of surveillance systems to capture these risks. Wellcome 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32810/1/A%20protocol%20for%20a%20longitudinal%2C%20observational%20cohort%20study%20of%20infection%20and%20exposure%20to%20zoonotic%20and%20vector-borne%20diseases%20across%20a%20land-use%20gradient%20in%20Sabah%2C%20Malaysian%20Borneo.pdf text en https://eprints.ums.edu.my/id/eprint/32810/3/Wellcome%20Open%20Research.pdf Kimberly Fornace and Benny Obrain Manin and Jason Matthiopoulos and Heather M Ferguson and Chris Drakeley and Kamruddin Ahmed and Koay, Teng Khoon and Robert M Ewers and Sylvia Daim and Tock, Hing Chua (2022) A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach. Wellcome Open Research. ISSN 2398-502X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886174/pdf/wellcomeopenres-7-19556.pdf https://doi.org/10.12688/wellcomeopenres.17678.1
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RC109-216 Infectious and parasitic diseases
RC31-1245 Internal medicine
spellingShingle RC109-216 Infectious and parasitic diseases
RC31-1245 Internal medicine
Kimberly Fornace
Benny Obrain Manin
Jason Matthiopoulos
Heather M Ferguson
Chris Drakeley
Kamruddin Ahmed
Koay, Teng Khoon
Robert M Ewers
Sylvia Daim
Tock, Hing Chua
A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
description Introduction. Landscape changes disrupt environmental, social and biological systems, altering pathogen spillover and transmission risks. This study aims to quantify the impact of specific land management practices on spillover and transmission rates of zoonotic and vector-borne diseases within Malaysian Borneo. This protocol describes a cohort study with integrated ecological sampling to assess how deforestation and agricultural practices impact pathogen flow from wildlife and vector populations to human infection and detection by health facilities. This will focus on malaria, dengue and emerging arboviruses (Chikungunya and Zika), vector-borne diseases with varying contributions of simian reservoirs within this setting. Methods. A prospective longitudinal observational cohort study will be established in communities residing or working within the vicinity of the Stability of Altered Forest Ecosystems (SAFE) Project, a landscape gradient within Malaysian Borneo encompassing different plantation and forest types. The primary outcome of this study will be transmission intensity of selected zoonotic and vector-borne diseases, as quantified by changes in pathogen-specific antibody levels. Exposure will be measured using paired population-based serological surveys conducted at the beginning and end of the two-year cohort study. Secondary outcomes will include the distribution and infection rates of Aedes and Anopheles mosquito vectors, human risk behaviours and clinical cases reported to health facilities. Longitudinal data on human behaviour, contact with wildlife and GPS tracking of mobility patterns will be collected throughout the study period. This will be integrated with entomological surveillance to monitor densities and pathogen infection rates of Aedes and Anopheles mosquitoes relative to land cover. Within surrounding health clinics, continuous health facility surveillance will be used to monitor reported infections and febrile illnesses. Models will be developed to assess spillover and transmission rates relative to specific land management practices and evaluate abilities of surveillance systems to capture these risks.
format Article
author Kimberly Fornace
Benny Obrain Manin
Jason Matthiopoulos
Heather M Ferguson
Chris Drakeley
Kamruddin Ahmed
Koay, Teng Khoon
Robert M Ewers
Sylvia Daim
Tock, Hing Chua
author_facet Kimberly Fornace
Benny Obrain Manin
Jason Matthiopoulos
Heather M Ferguson
Chris Drakeley
Kamruddin Ahmed
Koay, Teng Khoon
Robert M Ewers
Sylvia Daim
Tock, Hing Chua
author_sort Kimberly Fornace
title A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
title_short A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
title_full A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
title_fullStr A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
title_full_unstemmed A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach
title_sort protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in sabah, malaysian borneo: a socio-ecological systems approach
publisher Wellcome
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/32810/1/A%20protocol%20for%20a%20longitudinal%2C%20observational%20cohort%20study%20of%20infection%20and%20exposure%20to%20zoonotic%20and%20vector-borne%20diseases%20across%20a%20land-use%20gradient%20in%20Sabah%2C%20Malaysian%20Borneo.pdf
https://eprints.ums.edu.my/id/eprint/32810/3/Wellcome%20Open%20Research.pdf
https://eprints.ums.edu.my/id/eprint/32810/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886174/pdf/wellcomeopenres-7-19556.pdf
https://doi.org/10.12688/wellcomeopenres.17678.1
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score 13.211869

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