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Potential health benefits of curcumin on female reproductive disorders: A review

Curcumin is one of the main polyphenolic compounds in the turmeric rhizome. It possesses antioxidant, anti-inflammatory, anti-cancer, anti-arthritis, anti-asthmatic, anti-microbial, anti-viral and anti-fungal properties. This review aims to provide an overview of the potential health benefits of cur...

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Main Authors: Datu Agasi Mohd Kamal, Norizam Salamt, Allia Najmie Muhammad Yusuf, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar
Format: Article
Language:English
English
Published: MDPI 2021
Subjects:
RG211-483 Abnormalities and diseases of the female genital organs
RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:https://eprints.ums.edu.my/id/eprint/32579/1/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/32579/2/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.pdf
https://eprints.ums.edu.my/id/eprint/32579/
https://www.mdpi.com/2072-6643/13/9/3126/htm
https://doi.org/10.3390/nu13093126
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spelling my.ums.eprints.325792022-05-18T04:04:57Z https://eprints.ums.edu.my/id/eprint/32579/ Potential health benefits of curcumin on female reproductive disorders: A review Datu Agasi Mohd Kamal Norizam Salamt Allia Najmie Muhammad Yusuf Mohd Izhar Ariff Mohd Kashim Mohd Helmy Mokhtar RG211-483 Abnormalities and diseases of the female genital organs RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Curcumin is one of the main polyphenolic compounds in the turmeric rhizome. It possesses antioxidant, anti-inflammatory, anti-cancer, anti-arthritis, anti-asthmatic, anti-microbial, anti-viral and anti-fungal properties. This review aims to provide an overview of the potential health benefits of curcumin to treat female reproductive disorders, including polycystic ovary syndrome (PCOS), ovarian failure and endometriosis. Comprehensive information on curcumin was retrieved from electronic databases, which were MEDLINE via EBSCOhost, Scopus and Google Scholar. The available evidence showed that curcumin reduced the high level of androgen in PCOS. Studies in rodents suggest that curcumin resulted in the disappearance of cysts and the appearance of healthy follicles and corpora lutea. Furthermore, animal studies showed curcumin improved the overall function of the ovary in ovarian diseases and reversed the disturbance in oxidative stress parameters. Meanwhile, in vitro and in vivo studies reported the positive effects of curcumin in alleviating endometriosis through anti-inflammatory, anti-proliferative, anti-angiogenic and pro-apoptotic mechanisms. Thus, curcumin possesses various effects on PCOS, ovarian diseases and endometriosis. Some studies found considerable therapeutic effects, whereas others found no effect. However, none of the investigations found curcumin to be harmful. Curcumin clinical trials in endometriosis and ovarian illness are still scarce; thus, future studies need to be conducted to confirm the safety and efficacy of curcumin before it could be offered as a complementary therapy agent. MDPI 2021-09-07 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32579/1/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/32579/2/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.pdf Datu Agasi Mohd Kamal and Norizam Salamt and Allia Najmie Muhammad Yusuf and Mohd Izhar Ariff Mohd Kashim and Mohd Helmy Mokhtar (2021) Potential health benefits of curcumin on female reproductive disorders: A review. Nutrients, 13. pp. 1-21. ISSN 2072-6643 https://www.mdpi.com/2072-6643/13/9/3126/htm https://doi.org/10.3390/nu13093126
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RG211-483 Abnormalities and diseases of the female genital organs
RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle RG211-483 Abnormalities and diseases of the female genital organs
RS160-167 Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
Datu Agasi Mohd Kamal
Norizam Salamt
Allia Najmie Muhammad Yusuf
Mohd Izhar Ariff Mohd Kashim
Mohd Helmy Mokhtar
Potential health benefits of curcumin on female reproductive disorders: A review
description Curcumin is one of the main polyphenolic compounds in the turmeric rhizome. It possesses antioxidant, anti-inflammatory, anti-cancer, anti-arthritis, anti-asthmatic, anti-microbial, anti-viral and anti-fungal properties. This review aims to provide an overview of the potential health benefits of curcumin to treat female reproductive disorders, including polycystic ovary syndrome (PCOS), ovarian failure and endometriosis. Comprehensive information on curcumin was retrieved from electronic databases, which were MEDLINE via EBSCOhost, Scopus and Google Scholar. The available evidence showed that curcumin reduced the high level of androgen in PCOS. Studies in rodents suggest that curcumin resulted in the disappearance of cysts and the appearance of healthy follicles and corpora lutea. Furthermore, animal studies showed curcumin improved the overall function of the ovary in ovarian diseases and reversed the disturbance in oxidative stress parameters. Meanwhile, in vitro and in vivo studies reported the positive effects of curcumin in alleviating endometriosis through anti-inflammatory, anti-proliferative, anti-angiogenic and pro-apoptotic mechanisms. Thus, curcumin possesses various effects on PCOS, ovarian diseases and endometriosis. Some studies found considerable therapeutic effects, whereas others found no effect. However, none of the investigations found curcumin to be harmful. Curcumin clinical trials in endometriosis and ovarian illness are still scarce; thus, future studies need to be conducted to confirm the safety and efficacy of curcumin before it could be offered as a complementary therapy agent.
format Article
author Datu Agasi Mohd Kamal
Norizam Salamt
Allia Najmie Muhammad Yusuf
Mohd Izhar Ariff Mohd Kashim
Mohd Helmy Mokhtar
author_facet Datu Agasi Mohd Kamal
Norizam Salamt
Allia Najmie Muhammad Yusuf
Mohd Izhar Ariff Mohd Kashim
Mohd Helmy Mokhtar
author_sort Datu Agasi Mohd Kamal
title Potential health benefits of curcumin on female reproductive disorders: A review
title_short Potential health benefits of curcumin on female reproductive disorders: A review
title_full Potential health benefits of curcumin on female reproductive disorders: A review
title_fullStr Potential health benefits of curcumin on female reproductive disorders: A review
title_full_unstemmed Potential health benefits of curcumin on female reproductive disorders: A review
title_sort potential health benefits of curcumin on female reproductive disorders: a review
publisher MDPI
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/32579/1/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/32579/2/Potential%20health%20benefits%20of%20curcumin%20on%20female%20reproductive%20disorders%2C%20A%20review.pdf
https://eprints.ums.edu.my/id/eprint/32579/
https://www.mdpi.com/2072-6643/13/9/3126/htm
https://doi.org/10.3390/nu13093126
_version_ 1760231045409538048
score 13.211869

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