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Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis

More than 1.75 million COVID-19 infections and 16 thousand associated deaths have been reported in Malaysia. A meta-analysis on the prevalence of COVID-19 in different clinical stages before the National COVID-19 Vaccination Program in Malaysia is still lacking. To address this, the disease severity...

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Main Authors: Jun, Wei Ng, Chong, Eric Tzyy Jiann, Yee, Ann Tan, Heng, Gee Lee, Lan, Lan Chan, Qin, Zhi Lee, Yen, Tsen Saw, Yiko, Wong, Ahmad Aizudeen Bin Zakaria, Zarina Amin, Lee, Ping-Chin
Format: Article
Language:English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2022
Subjects:
RA1-1270 Public aspects of medicine
Online Access:https://eprints.ums.edu.my/id/eprint/32462/1/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia.pdf
https://eprints.ums.edu.my/id/eprint/32462/3/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia%20_ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/32462/
https://www.mdpi.com/1660-4601/19/4/2216/htm
https://doi.org/10.3390/ijerph19042216
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spelling my.ums.eprints.324622022-04-25T03:47:34Z https://eprints.ums.edu.my/id/eprint/32462/ Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis Jun, Wei Ng Chong, Eric Tzyy Jiann Yee, Ann Tan Heng, Gee Lee Lan, Lan Chan Qin, Zhi Lee Yen, Tsen Saw Yiko, Wong Ahmad Aizudeen Bin Zakaria Zarina Amin Lee, Ping-Chin RA1-1270 Public aspects of medicine More than 1.75 million COVID-19 infections and 16 thousand associated deaths have been reported in Malaysia. A meta-analysis on the prevalence of COVID-19 in different clinical stages before the National COVID-19 Vaccination Program in Malaysia is still lacking. To address this, the disease severity of a total of 215 admitted COVID-19 patients was initially recorded in the early phase of this study, and the data were later pooled into a meta-analysis with the aim of providing insight into the prevalence of COVID-19 in 5 different clinical stages during the outset of the COVID-19 pandemic in Malaysia. We have conducted a systematic literature search using PubMed, Web of Science, Scopus, ScienceDirect, and two preprint databases (bioRxiv and medRxiv) for relevant studies with specified inclusion and exclusion criteria. The quality assessment for the included studies was performed using the Newcastle–Ottawa Scale. The heterogeneity was examined with an I2 index and a Q-test. Funnel plots and Egger’s tests were performed to determine publication bias in this meta-analysis. Overall, 5 studies with 6375 patients were included, and the pooled prevalence rates in this meta-analysis were calculated using a random-effect model. The highest prevalence of COVID-19 in Malaysia was observed in Stage 2 cases (32.0%), followed by Stage 1 (27.8%), Stage 3 (17.1%), Stage 4 (7.6%), and Stage 5 (3.4%). About two-thirds of the number of cases have at least one morbidity, with the highest percentage of hypertension (66.7%), obesity (55.5%), or diabetes mellitus (33.3%) in Stage 5 patients. In conclusion, this meta-analysis suggested a high prevalence of COVID-19 occurred in Stage 2. The prevalence rate in Stage 5 appeared to be the lowest among COVID-19 patients before implementing the vaccination program in Malaysia. These meta-analysis data are critically useful for designing screening and vaccination programs and improving disease management in the country. Multidisciplinary Digital Publishing Institute (MDPI) 2022 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32462/1/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia.pdf text en https://eprints.ums.edu.my/id/eprint/32462/3/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia%20_ABSTRACT.pdf Jun, Wei Ng and Chong, Eric Tzyy Jiann and Yee, Ann Tan and Heng, Gee Lee and Lan, Lan Chan and Qin, Zhi Lee and Yen, Tsen Saw and Yiko, Wong and Ahmad Aizudeen Bin Zakaria and Zarina Amin and Lee, Ping-Chin (2022) Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 19. pp. 1-12. ISSN 1660-4601 https://www.mdpi.com/1660-4601/19/4/2216/htm https://doi.org/10.3390/ijerph19042216
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RA1-1270 Public aspects of medicine
spellingShingle RA1-1270 Public aspects of medicine
Jun, Wei Ng
Chong, Eric Tzyy Jiann
Yee, Ann Tan
Heng, Gee Lee
Lan, Lan Chan
Qin, Zhi Lee
Yen, Tsen Saw
Yiko, Wong
Ahmad Aizudeen Bin Zakaria
Zarina Amin
Lee, Ping-Chin
Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
description More than 1.75 million COVID-19 infections and 16 thousand associated deaths have been reported in Malaysia. A meta-analysis on the prevalence of COVID-19 in different clinical stages before the National COVID-19 Vaccination Program in Malaysia is still lacking. To address this, the disease severity of a total of 215 admitted COVID-19 patients was initially recorded in the early phase of this study, and the data were later pooled into a meta-analysis with the aim of providing insight into the prevalence of COVID-19 in 5 different clinical stages during the outset of the COVID-19 pandemic in Malaysia. We have conducted a systematic literature search using PubMed, Web of Science, Scopus, ScienceDirect, and two preprint databases (bioRxiv and medRxiv) for relevant studies with specified inclusion and exclusion criteria. The quality assessment for the included studies was performed using the Newcastle–Ottawa Scale. The heterogeneity was examined with an I2 index and a Q-test. Funnel plots and Egger’s tests were performed to determine publication bias in this meta-analysis. Overall, 5 studies with 6375 patients were included, and the pooled prevalence rates in this meta-analysis were calculated using a random-effect model. The highest prevalence of COVID-19 in Malaysia was observed in Stage 2 cases (32.0%), followed by Stage 1 (27.8%), Stage 3 (17.1%), Stage 4 (7.6%), and Stage 5 (3.4%). About two-thirds of the number of cases have at least one morbidity, with the highest percentage of hypertension (66.7%), obesity (55.5%), or diabetes mellitus (33.3%) in Stage 5 patients. In conclusion, this meta-analysis suggested a high prevalence of COVID-19 occurred in Stage 2. The prevalence rate in Stage 5 appeared to be the lowest among COVID-19 patients before implementing the vaccination program in Malaysia. These meta-analysis data are critically useful for designing screening and vaccination programs and improving disease management in the country.
format Article
author Jun, Wei Ng
Chong, Eric Tzyy Jiann
Yee, Ann Tan
Heng, Gee Lee
Lan, Lan Chan
Qin, Zhi Lee
Yen, Tsen Saw
Yiko, Wong
Ahmad Aizudeen Bin Zakaria
Zarina Amin
Lee, Ping-Chin
author_facet Jun, Wei Ng
Chong, Eric Tzyy Jiann
Yee, Ann Tan
Heng, Gee Lee
Lan, Lan Chan
Qin, Zhi Lee
Yen, Tsen Saw
Yiko, Wong
Ahmad Aizudeen Bin Zakaria
Zarina Amin
Lee, Ping-Chin
author_sort Jun, Wei Ng
title Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
title_short Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
title_full Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
title_fullStr Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
title_full_unstemmed Prevalence of coronavirus disease 2019 (COVID-19) in different clinical stages before the national COVID-19 vaccination programme in Malaysia: A systematic review and meta-analysis
title_sort prevalence of coronavirus disease 2019 (covid-19) in different clinical stages before the national covid-19 vaccination programme in malaysia: a systematic review and meta-analysis
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2022
url https://eprints.ums.edu.my/id/eprint/32462/1/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia.pdf
https://eprints.ums.edu.my/id/eprint/32462/3/Prevalence%20of%20coronavirus%20disease%202019%20%28COVID-19%29%20in%20different%20clinical%20stages%20before%20the%20national%20covid-19%20vaccination%20programme%20in%20Malaysia%20_ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/32462/
https://www.mdpi.com/1660-4601/19/4/2216/htm
https://doi.org/10.3390/ijerph19042216
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score 13.211869

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