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The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats

Background. Potential antibacterial substances, such as titanium dioxide (TiO2), are being extensively studied throughout the research world. A modified hydrothermal Nano Titania extraction was shown to inhibit Staphylococcus aureus growth in the laboratory. However, the toxicity effect of the extra...

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Main Authors: Ahmad Mukifza Harun, Huzaika Awang, Nor Farid Mohd Noor, Nur Mohamad Makhatar, Mohamad Ezany Yusoff, Nor Dalila Nor Affandi, Mohammad Khursheed Alam
Format: Article
Language:English
English
Published: Hindawi Publishing Corporation 2021
Subjects:
TA1-2040 Engineering (General). Civil engineering (General)
Online Access:https://eprints.ums.edu.my/id/eprint/32038/1/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats.pdf
https://eprints.ums.edu.my/id/eprint/32038/2/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats1.pdf
https://eprints.ums.edu.my/id/eprint/32038/
https://www.hindawi.com/journals/bmri/2021/6173143/
https://doi.org/10.1155/2021/6173143
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spelling my.ums.eprints.320382022-03-28T01:44:04Z https://eprints.ums.edu.my/id/eprint/32038/ The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats Ahmad Mukifza Harun Huzaika Awang Nor Farid Mohd Noor Nur Mohamad Makhatar Mohamad Ezany Yusoff Nor Dalila Nor Affandi Mohammad Khursheed Alam TA1-2040 Engineering (General). Civil engineering (General) Background. Potential antibacterial substances, such as titanium dioxide (TiO2), are being extensively studied throughout the research world. A modified hydrothermal Nano Titania extraction was shown to inhibit Staphylococcus aureus growth in the laboratory. However, the toxicity effect of the extract on rats is unknown. In this study, we observed the effects of a modified hydrothermal Nano Titania extraction on the skin and behavior of Sprague-Dawley rats. Methods. Sprague-Dawley (Rattus norvegicus) rats were used as the experimental animals. The skin around the dorsum of the tested animals was shaved and pasted with 0.1 mg and 0.5 mg of the Nano Titania extraction. The color and condition of the pasted area and the behavior of the animals were observed. Results. 0.1 mg Nano Titania extraction application on the dorsum of the rat produced no skin color changes at day 1, day 3, day 5, or day 7 post application. There were no changes in their behavior up to day 7 with no skin rashes or skin scratches seen or fur changes. However, 0.5 mg of Nano Titania extraction resulted in redness and less fur regrowth at day 7. Conclusions. A 0.1 mg modified Nano Titania extraction was observed to have no effect on the skin of Sprague-Dawley rats. Hindawi Publishing Corporation 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/32038/1/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats.pdf text en https://eprints.ums.edu.my/id/eprint/32038/2/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats1.pdf Ahmad Mukifza Harun and Huzaika Awang and Nor Farid Mohd Noor and Nur Mohamad Makhatar and Mohamad Ezany Yusoff and Nor Dalila Nor Affandi and Mohammad Khursheed Alam (2021) The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats. BioMed Research International, 2021. pp. 1-5. ISSN 2314-6141 https://www.hindawi.com/journals/bmri/2021/6173143/ https://doi.org/10.1155/2021/6173143
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic TA1-2040 Engineering (General). Civil engineering (General)
spellingShingle TA1-2040 Engineering (General). Civil engineering (General)
Ahmad Mukifza Harun
Huzaika Awang
Nor Farid Mohd Noor
Nur Mohamad Makhatar
Mohamad Ezany Yusoff
Nor Dalila Nor Affandi
Mohammad Khursheed Alam
The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
description Background. Potential antibacterial substances, such as titanium dioxide (TiO2), are being extensively studied throughout the research world. A modified hydrothermal Nano Titania extraction was shown to inhibit Staphylococcus aureus growth in the laboratory. However, the toxicity effect of the extract on rats is unknown. In this study, we observed the effects of a modified hydrothermal Nano Titania extraction on the skin and behavior of Sprague-Dawley rats. Methods. Sprague-Dawley (Rattus norvegicus) rats were used as the experimental animals. The skin around the dorsum of the tested animals was shaved and pasted with 0.1 mg and 0.5 mg of the Nano Titania extraction. The color and condition of the pasted area and the behavior of the animals were observed. Results. 0.1 mg Nano Titania extraction application on the dorsum of the rat produced no skin color changes at day 1, day 3, day 5, or day 7 post application. There were no changes in their behavior up to day 7 with no skin rashes or skin scratches seen or fur changes. However, 0.5 mg of Nano Titania extraction resulted in redness and less fur regrowth at day 7. Conclusions. A 0.1 mg modified Nano Titania extraction was observed to have no effect on the skin of Sprague-Dawley rats.
format Article
author Ahmad Mukifza Harun
Huzaika Awang
Nor Farid Mohd Noor
Nur Mohamad Makhatar
Mohamad Ezany Yusoff
Nor Dalila Nor Affandi
Mohammad Khursheed Alam
author_facet Ahmad Mukifza Harun
Huzaika Awang
Nor Farid Mohd Noor
Nur Mohamad Makhatar
Mohamad Ezany Yusoff
Nor Dalila Nor Affandi
Mohammad Khursheed Alam
author_sort Ahmad Mukifza Harun
title The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
title_short The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
title_full The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
title_fullStr The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
title_full_unstemmed The Photocatalytic Effects of Modified Hydrothermal Nano Titania Extraction on the Skin and Behavior of Sprague-Dawley Rats
title_sort photocatalytic effects of modified hydrothermal nano titania extraction on the skin and behavior of sprague-dawley rats
publisher Hindawi Publishing Corporation
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/32038/1/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats.pdf
https://eprints.ums.edu.my/id/eprint/32038/2/The%20Photocatalytic%20Effects%20of%20Modified%20Hydrothermal%20Nano%20Titania%20Extraction%20on%20the%20Skin%20and%20Behavior%20of%20Sprague-Dawley%20Rats1.pdf
https://eprints.ums.edu.my/id/eprint/32038/
https://www.hindawi.com/journals/bmri/2021/6173143/
https://doi.org/10.1155/2021/6173143
_version_ 1760230972059549696
score 13.211869

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