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Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells

Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomat...

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Main Authors: Perng Yang Puah, Pak, Yan Moh, Coswald Stephen Sipaut @ Mohd Nasri, Ping, Chin Lee, Siew, Eng How
Format: Article
Language:English
English
Published: Multidisciplinary Digital Publishing Institute (MDPI) 2021
Subjects:
Q1-295 General
QD1-999 Chemistry
Online Access:https://eprints.ums.edu.my/id/eprint/31529/1/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells.pdf
https://eprints.ums.edu.my/id/eprint/31529/2/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells1.pdf
https://eprints.ums.edu.my/id/eprint/31529/
https://www.mdpi.com/2073-4360/13/19/3290/htm
https://doi.org/10.3390/polym13193290
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spelling my.ums.eprints.315292021-12-22T09:56:15Z https://eprints.ums.edu.my/id/eprint/31529/ Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells Perng Yang Puah Pak, Yan Moh Coswald Stephen Sipaut @ Mohd Nasri Ping, Chin Lee Siew, Eng How Q1-295 General QD1-999 Chemistry Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated. The results demonstrated that the peptide conjugate on the m-GO film did not hamper the normal growth of WJ-MSCs but supported the growth of WJ-MSCs after the 6-day culture period. In addition, the osteogenic differentiation of WJMSCs on the peptide/m-GO films was enhanced as compared with the parent m-GO film. Therefore, such peptide-conjugated m-GO films could provide a highly biocompatible and multifunctional 2D material to tailor the potential application of WJ-MSCs in bone tissue regeneration. Multidisciplinary Digital Publishing Institute (MDPI) 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/31529/1/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells.pdf text en https://eprints.ums.edu.my/id/eprint/31529/2/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells1.pdf Perng Yang Puah and Pak, Yan Moh and Coswald Stephen Sipaut @ Mohd Nasri and Ping, Chin Lee and Siew, Eng How (2021) Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells. Polymers, 13 (3290). pp. 1-13. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/19/3290/htm https://doi.org/10.3390/polym13193290
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic Q1-295 General
QD1-999 Chemistry
spellingShingle Q1-295 General
QD1-999 Chemistry
Perng Yang Puah
Pak, Yan Moh
Coswald Stephen Sipaut @ Mohd Nasri
Ping, Chin Lee
Siew, Eng How
Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
description Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated. The results demonstrated that the peptide conjugate on the m-GO film did not hamper the normal growth of WJ-MSCs but supported the growth of WJ-MSCs after the 6-day culture period. In addition, the osteogenic differentiation of WJMSCs on the peptide/m-GO films was enhanced as compared with the parent m-GO film. Therefore, such peptide-conjugated m-GO films could provide a highly biocompatible and multifunctional 2D material to tailor the potential application of WJ-MSCs in bone tissue regeneration.
format Article
author Perng Yang Puah
Pak, Yan Moh
Coswald Stephen Sipaut @ Mohd Nasri
Ping, Chin Lee
Siew, Eng How
author_facet Perng Yang Puah
Pak, Yan Moh
Coswald Stephen Sipaut @ Mohd Nasri
Ping, Chin Lee
Siew, Eng How
author_sort Perng Yang Puah
title Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
title_short Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
title_full Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
title_fullStr Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
title_full_unstemmed Peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human Wharton’s jelly-derived mesenchymal stem cells
title_sort peptide conjugate on multilayer graphene oxide film for the osteogenic differentiation of human wharton’s jelly-derived mesenchymal stem cells
publisher Multidisciplinary Digital Publishing Institute (MDPI)
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/31529/1/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells.pdf
https://eprints.ums.edu.my/id/eprint/31529/2/Peptide%20conjugate%20on%20multilayer%20graphene%20oxide%20film%20for%20the%20osteogenic%20differentiation%20of%20human%20Wharton%E2%80%99s%20jelly-derived%20mesenchymal%20stem%20cells1.pdf
https://eprints.ums.edu.my/id/eprint/31529/
https://www.mdpi.com/2073-4360/13/19/3290/htm
https://doi.org/10.3390/polym13193290
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score 13.211869

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