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Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis

Although mumps virus (MuVi) is an important agent of encephalitis, however, mumps vaccine has not yet been included in the national immunization programme of Bangladesh. Furthermore, the genotype distribution of this virus in Bangladesh is unknown. Cerebrospinal fluid samples collected from 97 child...

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Main Authors: Daisuke Mori, Wahida Khanam, Kamruddin Ahmed
Format: Article
Language:English
English
Published: Universiti Malaysia Sabah 2021
Subjects:
RJ370-550 Diseases of children and adolescents
Online Access:https://eprints.ums.edu.my/id/eprint/30445/1/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/30445/2/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/30445/
https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2675/1920
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spelling my.ums.eprints.304452021-09-20T07:44:06Z https://eprints.ums.edu.my/id/eprint/30445/ Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis Daisuke Mori Wahida Khanam Kamruddin Ahmed RJ370-550 Diseases of children and adolescents Although mumps virus (MuVi) is an important agent of encephalitis, however, mumps vaccine has not yet been included in the national immunization programme of Bangladesh. Furthermore, the genotype distribution of this virus in Bangladesh is unknown. Cerebrospinal fluid samples collected from 97 children with encephalitis from April 2009 to March 2010 were subjected to polymerase chain reaction (PCR) test to determine the causative agents. MuVi was detected in two samples, these samples were further subjected to conventional PCR using specific primers, then amplicons were sequenced, and genotype was determined as genotype G. Phylogenetic analysis showed that these strains were clustered with strains from Nepal, India, the UK, Thailand, and the USA. By Bayesian inference, we also determined that the ancestor of Bangladeshi and Indian MuVi were same and segregated only about two decades back. These results will help future surveillance and the detection of invading MuVi strains from other countries. Universiti Malaysia Sabah 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/30445/1/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/30445/2/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20ABSTRACT.pdf Daisuke Mori and Wahida Khanam and Kamruddin Ahmed (2021) Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis. Borneo Journal of Medical Sciences, 15. pp. 73-79. ISSN 1985-1758 (P-ISSN) , 2710-7353 (E-ISSN) https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2675/1920
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic RJ370-550 Diseases of children and adolescents
spellingShingle RJ370-550 Diseases of children and adolescents
Daisuke Mori
Wahida Khanam
Kamruddin Ahmed
Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
description Although mumps virus (MuVi) is an important agent of encephalitis, however, mumps vaccine has not yet been included in the national immunization programme of Bangladesh. Furthermore, the genotype distribution of this virus in Bangladesh is unknown. Cerebrospinal fluid samples collected from 97 children with encephalitis from April 2009 to March 2010 were subjected to polymerase chain reaction (PCR) test to determine the causative agents. MuVi was detected in two samples, these samples were further subjected to conventional PCR using specific primers, then amplicons were sequenced, and genotype was determined as genotype G. Phylogenetic analysis showed that these strains were clustered with strains from Nepal, India, the UK, Thailand, and the USA. By Bayesian inference, we also determined that the ancestor of Bangladeshi and Indian MuVi were same and segregated only about two decades back. These results will help future surveillance and the detection of invading MuVi strains from other countries.
format Article
author Daisuke Mori
Wahida Khanam
Kamruddin Ahmed
author_facet Daisuke Mori
Wahida Khanam
Kamruddin Ahmed
author_sort Daisuke Mori
title Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
title_short Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
title_full Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
title_fullStr Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
title_full_unstemmed Detection of Mumps virus of Genotype G in Bangladeshi children suffering from Encephalitis
title_sort detection of mumps virus of genotype g in bangladeshi children suffering from encephalitis
publisher Universiti Malaysia Sabah
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/30445/1/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/30445/2/Detection%20of%20Mumps%20Virus%20of%20Genotype%20G%20in%20Bangladeshi%20Children%20Suffering%20from%20Encephalitis%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/30445/
https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2675/1920
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score 13.211869

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