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Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review

Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders t...

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Main Authors: Kok Yeow Phneh, Chong, Eric Tzyy Jiann, Lee, Ping Chin
Format: Article
Language:English
English
Published: Elsevier B.V. 2021
Subjects:
TP Chemical technology
Online Access:https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/30110/
https://www.sciencedirect.com/science/article/pii/S221454002100030X?casa_token=RPsboh54_rYAAAAA:dkYW6i-OUU5jzEjBxKKG8_HVB7JYG3ax6GPbRpBtbpERW7Vo1IHAFSOscrHtm1NMLbt8fFNSuE5-
https://doi.org/10.1016/j.mgene.2021.100879
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spelling my.ums.eprints.301102021-07-28T02:37:16Z https://eprints.ums.edu.my/id/eprint/30110/ Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review Kok Yeow Phneh Chong, Eric Tzyy Jiann Lee, Ping Chin TP Chemical technology Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders that subsequently lead to the development of stroke incidence. To date, constructive information that summarizes this particular relationship is limited. Hence, this comprehensive review focuses on the role of SNPs in facilitating susceptibility to several health disorders including brain aneurysms, atrial fibrillation, atherosclerosis, and hyperlipidemia, and their association with the development of higher stroke incidence. We discussed a total of 33 SNPs in this review that includes 11 SNPs associated with brain aneurysms, 4 SNPs associated with atrial fibrillation, 13 SNPs associated with atherosclerosis, and 5 SNPs associated with hyperlipidemia. The SNPs data could assist in determining an individual’s risk of different health disorders and subsequently stroke. Therefore, pharmacogenomics could be applied to effectively provide appropriate personalized medications and genetic counseling. Elsevier B.V. 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf text en https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf Kok Yeow Phneh and Chong, Eric Tzyy Jiann and Lee, Ping Chin (2021) Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review. Meta Gene, 28. pp. 1-8. ISSN 2214-5400 (E-ISSN) https://www.sciencedirect.com/science/article/pii/S221454002100030X?casa_token=RPsboh54_rYAAAAA:dkYW6i-OUU5jzEjBxKKG8_HVB7JYG3ax6GPbRpBtbpERW7Vo1IHAFSOscrHtm1NMLbt8fFNSuE5- https://doi.org/10.1016/j.mgene.2021.100879
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic TP Chemical technology
spellingShingle TP Chemical technology
Kok Yeow Phneh
Chong, Eric Tzyy Jiann
Lee, Ping Chin
Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
description Stroke is the second‑leading cause of global mortality and the third leading cause of disability. Numerous in-dependent studies have reported that genetic mutations such as single nucleotide polymorphisms (SNPs) within genes may alter an individual’s susceptibility towards several health disorders that subsequently lead to the development of stroke incidence. To date, constructive information that summarizes this particular relationship is limited. Hence, this comprehensive review focuses on the role of SNPs in facilitating susceptibility to several health disorders including brain aneurysms, atrial fibrillation, atherosclerosis, and hyperlipidemia, and their association with the development of higher stroke incidence. We discussed a total of 33 SNPs in this review that includes 11 SNPs associated with brain aneurysms, 4 SNPs associated with atrial fibrillation, 13 SNPs associated with atherosclerosis, and 5 SNPs associated with hyperlipidemia. The SNPs data could assist in determining an individual’s risk of different health disorders and subsequently stroke. Therefore, pharmacogenomics could be applied to effectively provide appropriate personalized medications and genetic counseling.
format Article
author Kok Yeow Phneh
Chong, Eric Tzyy Jiann
Lee, Ping Chin
author_facet Kok Yeow Phneh
Chong, Eric Tzyy Jiann
Lee, Ping Chin
author_sort Kok Yeow Phneh
title Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
title_short Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
title_full Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
title_fullStr Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
title_full_unstemmed Role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
title_sort role of single nucleotide polymorphisms in susceptibility of stroke: a systemic review
publisher Elsevier B.V.
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/30110/1/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/30110/2/Role%20of%20single%20nucleotide%20polymorphisms%20in%20susceptibility%20of%20stroke_%20a%20systemic%20review%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/30110/
https://www.sciencedirect.com/science/article/pii/S221454002100030X?casa_token=RPsboh54_rYAAAAA:dkYW6i-OUU5jzEjBxKKG8_HVB7JYG3ax6GPbRpBtbpERW7Vo1IHAFSOscrHtm1NMLbt8fFNSuE5-
https://doi.org/10.1016/j.mgene.2021.100879
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score 13.211869

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