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Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction

Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid...

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Main Authors: Md. Ariful Alam, I. S. M. Zaidul, Kashif Ghafoor, Sahena Ferdosh, Md. Eaqub Ali, H. Mirhosseini, B. Y. Kamaruzzaman, Md Jahurul Haque Akanda, A. Khatib
Format: Article
Language:English
Published: Taylor & Francis Group 2021
Subjects:
QD Chemistry
QK Botany
Online Access:https://eprints.ums.edu.my/id/eprint/27531/1/Identification%20of%20bioactive%20compounds%20with%20GC%20Q-TOF%20MS%20in%20the%20extracts%20from%20Clinacanthus%20nutans%20using%20subcritical%20carbon%20dioxide%20extraction%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/27531/
https://www.tandfonline.com/doi/full/10.1080/01496395.2016.1271342
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spelling my.ums.eprints.275312021-06-30T12:21:01Z https://eprints.ums.edu.my/id/eprint/27531/ Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction Md. Ariful Alam I. S. M. Zaidul Kashif Ghafoor Sahena Ferdosh Md. Eaqub Ali H. Mirhosseini B. Y. Kamaruzzaman Md Jahurul Haque Akanda A. Khatib QD Chemistry QK Botany Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC-Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity. Taylor & Francis Group 2021 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/27531/1/Identification%20of%20bioactive%20compounds%20with%20GC%20Q-TOF%20MS%20in%20the%20extracts%20from%20Clinacanthus%20nutans%20using%20subcritical%20carbon%20dioxide%20extraction%20ABSTRACT.pdf Md. Ariful Alam and I. S. M. Zaidul and Kashif Ghafoor and Sahena Ferdosh and Md. Eaqub Ali and H. Mirhosseini and B. Y. Kamaruzzaman and Md Jahurul Haque Akanda and A. Khatib (2021) Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction. Separation Science and Technology, 52 (5). pp. 852-863. ISSN 1520-5754 https://www.tandfonline.com/doi/full/10.1080/01496395.2016.1271342 10.1080/01496395.2016.1271342
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QD Chemistry
QK Botany
spellingShingle QD Chemistry
QK Botany
Md. Ariful Alam
I. S. M. Zaidul
Kashif Ghafoor
Sahena Ferdosh
Md. Eaqub Ali
H. Mirhosseini
B. Y. Kamaruzzaman
Md Jahurul Haque Akanda
A. Khatib
Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
description Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC-Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity.
format Article
author Md. Ariful Alam
I. S. M. Zaidul
Kashif Ghafoor
Sahena Ferdosh
Md. Eaqub Ali
H. Mirhosseini
B. Y. Kamaruzzaman
Md Jahurul Haque Akanda
A. Khatib
author_facet Md. Ariful Alam
I. S. M. Zaidul
Kashif Ghafoor
Sahena Ferdosh
Md. Eaqub Ali
H. Mirhosseini
B. Y. Kamaruzzaman
Md Jahurul Haque Akanda
A. Khatib
author_sort Md. Ariful Alam
title Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
title_short Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
title_full Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
title_fullStr Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
title_full_unstemmed Identification of bioactive compounds with GC Q-TOF MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction
title_sort identification of bioactive compounds with gc q-tof ms in the extracts from clinacanthus nutans using subcritical carbon dioxide extraction
publisher Taylor & Francis Group
publishDate 2021
url https://eprints.ums.edu.my/id/eprint/27531/1/Identification%20of%20bioactive%20compounds%20with%20GC%20Q-TOF%20MS%20in%20the%20extracts%20from%20Clinacanthus%20nutans%20using%20subcritical%20carbon%20dioxide%20extraction%20ABSTRACT.pdf
https://eprints.ums.edu.my/id/eprint/27531/
https://www.tandfonline.com/doi/full/10.1080/01496395.2016.1271342
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score 13.211869

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