Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-l-DOPA
A series of novel α-methyl-l-DOPA urea derivatives viz., 3-(3,4-dihydroxyphenyl)-2-methyl-2-(3-halo/trifluoromethyl substituted phenyl ureido)propanoic acids (6a-e) have been synthesized from the reaction of α-methyl-l-DOPA (3) with various aryl isocyanates (4a-e) by using triethylamine (5, TEA) as...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/25931/1/Multiple%20molecular%20targets%20mediated%20antioxidant%20activity%2C%20molecular%20docking%2C%20ADMET%2C%20QSAR%20and%20bioactivity%20studies%20of%20halo%20substituted%20urea%20derivatives%20of%C2%A0%CE%B1-Methyl-l-DOPA.pdf https://eprints.ums.edu.my/id/eprint/25931/ https://doi.org/10.1016/j.bioorg.2020.103708 |
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