Staff View: Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

Phytosterols (PSs) are insoluble in water and poorly soluble in oil, which hampers their potential as cholesterol level regulator in human. To mitigate this problem, monoglycerides (MGs) were used to modulates the crystallization behavior of PSs. Therefore, the understanding on mixing behavior provi...

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Main Authors:	Mohd Dona Sintang, Sabine M Danthine, Dmitry Khalenkow, Iris Tavernier, Daylan A. Tzompa-Sosa, Norliza Binti Julmohammad, Davy Van de Walle, Tom Rimaux, Andre Skirtach, Koen Dewettinck
Format:	Article
Language:	English
Published:	2020
Subjects:	TX341-641 Nutrition. Foods and food supply
Online Access:	https://eprints.ums.edu.my/id/eprint/25790/1/Modulating%20the%20crystallization%20of%20phytosterols%20with%20monoglycerides%20in%20the%20binary.pdf https://eprints.ums.edu.my/id/eprint/25790/ https://doi.org/10.1016/j.chemphyslip.2020.104912
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spelling	my.ums.eprints.257902020-08-12T02:56:00Z https://eprints.ums.edu.my/id/eprint/25790/ Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation Mohd Dona Sintang Sabine M Danthine Dmitry Khalenkow Iris Tavernier Daylan A. Tzompa-Sosa Norliza Binti Julmohammad Davy Van de Walle Tom Rimaux Andre Skirtach Koen Dewettinck TX341-641 Nutrition. Foods and food supply Phytosterols (PSs) are insoluble in water and poorly soluble in oil, which hampers their potential as cholesterol level regulator in human. To mitigate this problem, monoglycerides (MGs) were used to modulates the crystallization behavior of PSs. Therefore, the understanding on mixing behavior provides the insight into different aspects of crystallization and the resultant effects. The effects on thermal, morphology, diffraction, and spectroscopy behavior were investigated for binary mixtures of 11 different ratios (100:0 to 0:100 MGs:PSs). The phase behavior of binary mixtures of commercial MGs and PSs exhibited complexity with the formation of eutectic mixtures at 90:10 and 80:20 (MGs:PSs) combinations. These combinations revealed a single melting profile and reduced melting enthalpy, though after a month of storage at 5 °C. Conversely, two separate melting regions were observed in others. Furthermore, powder X-ray diffraction (PXRD) analysis of selected combinations revealed a change in crystalline forms with changes in the peaks located between 18-19° (2θ) and 25-26° (2θ). Accordingly, Raman spectroscopy results revealed changes in intensities and peak shape. Therefore, the change in crystalline forms or behavior correlated well to the change in thermal properties. Overall, the characterizations revealed the formation of eutectic mixtures between MGs and PSs at 90:10 and 80:20 (MGs:PSs) in which MGs modified the crystallization of PSs and changed the crystal forms thus, thermal behaviors. This study provides new insight into the mixing behavior of MGs and PSs which supports other research. Therefore, the results of this study are beneficial for the improvement of formulation of phytosterols in food and pharmaceutical products. Nonetheless, this study reveals a simple technique to alter crystal forms of phytosterols through simple complexation with monoglycerides. 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25790/1/Modulating%20the%20crystallization%20of%20phytosterols%20with%20monoglycerides%20in%20the%20binary.pdf Mohd Dona Sintang and Sabine M Danthine and Dmitry Khalenkow and Iris Tavernier and Daylan A. Tzompa-Sosa and Norliza Binti Julmohammad and Davy Van de Walle and Tom Rimaux and Andre Skirtach and Koen Dewettinck (2020) Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation. Chemistry and Physics of Lipids, 230. https://doi.org/10.1016/j.chemphyslip.2020.104912
institution	Universiti Malaysia Sabah
building	UMS Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Sabah
content_source	UMS Institutional Repository
url_provider	http://eprints.ums.edu.my/
language	English
topic	TX341-641 Nutrition. Foods and food supply
spellingShingle	TX341-641 Nutrition. Foods and food supply Mohd Dona Sintang Sabine M Danthine Dmitry Khalenkow Iris Tavernier Daylan A. Tzompa-Sosa Norliza Binti Julmohammad Davy Van de Walle Tom Rimaux Andre Skirtach Koen Dewettinck Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
description	Phytosterols (PSs) are insoluble in water and poorly soluble in oil, which hampers their potential as cholesterol level regulator in human. To mitigate this problem, monoglycerides (MGs) were used to modulates the crystallization behavior of PSs. Therefore, the understanding on mixing behavior provides the insight into different aspects of crystallization and the resultant effects. The effects on thermal, morphology, diffraction, and spectroscopy behavior were investigated for binary mixtures of 11 different ratios (100:0 to 0:100 MGs:PSs). The phase behavior of binary mixtures of commercial MGs and PSs exhibited complexity with the formation of eutectic mixtures at 90:10 and 80:20 (MGs:PSs) combinations. These combinations revealed a single melting profile and reduced melting enthalpy, though after a month of storage at 5 °C. Conversely, two separate melting regions were observed in others. Furthermore, powder X-ray diffraction (PXRD) analysis of selected combinations revealed a change in crystalline forms with changes in the peaks located between 18-19° (2θ) and 25-26° (2θ). Accordingly, Raman spectroscopy results revealed changes in intensities and peak shape. Therefore, the change in crystalline forms or behavior correlated well to the change in thermal properties. Overall, the characterizations revealed the formation of eutectic mixtures between MGs and PSs at 90:10 and 80:20 (MGs:PSs) in which MGs modified the crystallization of PSs and changed the crystal forms thus, thermal behaviors. This study provides new insight into the mixing behavior of MGs and PSs which supports other research. Therefore, the results of this study are beneficial for the improvement of formulation of phytosterols in food and pharmaceutical products. Nonetheless, this study reveals a simple technique to alter crystal forms of phytosterols through simple complexation with monoglycerides.
format	Article
author	Mohd Dona Sintang Sabine M Danthine Dmitry Khalenkow Iris Tavernier Daylan A. Tzompa-Sosa Norliza Binti Julmohammad Davy Van de Walle Tom Rimaux Andre Skirtach Koen Dewettinck
author_facet	Mohd Dona Sintang Sabine M Danthine Dmitry Khalenkow Iris Tavernier Daylan A. Tzompa-Sosa Norliza Binti Julmohammad Davy Van de Walle Tom Rimaux Andre Skirtach Koen Dewettinck
author_sort	Mohd Dona Sintang
title	Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
title_short	Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
title_full	Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
title_fullStr	Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
title_full_unstemmed	Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
title_sort	modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
publishDate	2020
url	https://eprints.ums.edu.my/id/eprint/25790/1/Modulating%20the%20crystallization%20of%20phytosterols%20with%20monoglycerides%20in%20the%20binary.pdf https://eprints.ums.edu.my/id/eprint/25790/ https://doi.org/10.1016/j.chemphyslip.2020.104912
_version_	1760230414211874816
score	13.211869

Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

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