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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo

Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide(1),(E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca [β]furan-2(3H)-one (...

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Main Authors: Takashi Kamada, Min-Cheol Kang, Phan, Chin Soon, Intan Irna Zanil, You-Jin Jeon, Charles Santhanaraju Vairappan
Format: Article
Language:English
Published: 2018
Subjects:
QH301-705.5 Biology (General)
QK Botany
Online Access:https://eprints.ums.edu.my/id/eprint/25522/1/Bioactive%20Cembranoids%20from%20the%20Soft%20Coral%20Genus%20Sinularia%20sp.%20in%20Borneo.pdf
https://eprints.ums.edu.my/id/eprint/25522/
https://doi.org/doi:10.3390/md16040099
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spelling my.ums.eprints.255222020-06-19T00:13:26Z https://eprints.ums.edu.my/id/eprint/25522/ Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo Takashi Kamada Min-Cheol Kang Phan, Chin Soon Intan Irna Zanil You-Jin Jeon Charles Santhanaraju Vairappan QH301-705.5 Biology (General) QK Botany Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide(1),(E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca [β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC50 values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25522/1/Bioactive%20Cembranoids%20from%20the%20Soft%20Coral%20Genus%20Sinularia%20sp.%20in%20Borneo.pdf Takashi Kamada and Min-Cheol Kang and Phan, Chin Soon and Intan Irna Zanil and You-Jin Jeon and Charles Santhanaraju Vairappan (2018) Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo. marine drugs, 16 (99). pp. 1-14. https://doi.org/doi:10.3390/md16040099
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QH301-705.5 Biology (General)
QK Botany
spellingShingle QH301-705.5 Biology (General)
QK Botany
Takashi Kamada
Min-Cheol Kang
Phan, Chin Soon
Intan Irna Zanil
You-Jin Jeon
Charles Santhanaraju Vairappan
Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
description Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide(1),(E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca [β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC50 values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations.
format Article
author Takashi Kamada
Min-Cheol Kang
Phan, Chin Soon
Intan Irna Zanil
You-Jin Jeon
Charles Santhanaraju Vairappan
author_facet Takashi Kamada
Min-Cheol Kang
Phan, Chin Soon
Intan Irna Zanil
You-Jin Jeon
Charles Santhanaraju Vairappan
author_sort Takashi Kamada
title Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_short Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_full Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_fullStr Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_full_unstemmed Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_sort bioactive cembranoids from the soft coral genus sinularia sp. in borneo
publishDate 2018
url https://eprints.ums.edu.my/id/eprint/25522/1/Bioactive%20Cembranoids%20from%20the%20Soft%20Coral%20Genus%20Sinularia%20sp.%20in%20Borneo.pdf
https://eprints.ums.edu.my/id/eprint/25522/
https://doi.org/doi:10.3390/md16040099
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score 13.211869

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