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Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice

Lonicera japonica Thunb. has been widely used as food ingredients and healthy drinks in the Asian countries, which was reported to possess some good activities. However, it remains unknown in the immunomodulation of Lonicera japonica polysaccharides (LJP) on allergic rhinitis (AR). This study aime...

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Main Authors: Xinyu Bai, Yeewen Chai, Wanlan Shi, Yingying Li, Tao Zhang, Ping Liu
Format: Article
Language:English
Published: Elsevier 2020
Subjects:
QD Chemistry
Online Access:https://eprints.ums.edu.my/id/eprint/25504/1/Lonicera%20japonica%20polysaccharides%20attenuate%20ovalbumin-induced%20allergic%20rhinitis%20by%20regulation.pdf
https://eprints.ums.edu.my/id/eprint/25504/
https://doi.org/10.1016/j.jff.2019.103758
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spelling my.ums.eprints.255042020-06-10T07:30:18Z https://eprints.ums.edu.my/id/eprint/25504/ Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice Xinyu Bai Yeewen Chai Wanlan Shi Yingying Li Tao Zhang Ping Liu QD Chemistry Lonicera japonica Thunb. has been widely used as food ingredients and healthy drinks in the Asian countries, which was reported to possess some good activities. However, it remains unknown in the immunomodulation of Lonicera japonica polysaccharides (LJP) on allergic rhinitis (AR). This study aimed to investigate the impact of LJP on ovalbumin-induced AR in BALB/c mice model. LJP significantly inhibited AR symptoms and eosinophil number in nasal mucosa. Besides, the increased serum levels of IgE, TNF-α, IL-1β and IL-17 were markedly decreased when AR mice were treated with LJP. The mRNA expression levels of IL-4, IL-5, IL-6, IL-17, IL-23, ROR-γt and STAT3 in OVA group were increased, and SOCS3 was reduced, while LJP inhibited the changes. The present study indicated that LJP suppressed the inflammatory response in AR sensitized by ovalbumin, showing that LJP has the potential to treat AR through the regulation of Th17 cells. Elsevier 2020 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/25504/1/Lonicera%20japonica%20polysaccharides%20attenuate%20ovalbumin-induced%20allergic%20rhinitis%20by%20regulation.pdf Xinyu Bai and Yeewen Chai and Wanlan Shi and Yingying Li and Tao Zhang and Ping Liu (2020) Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice. Journal of Functional Foods, 65 (103758). ISSN 1756-4646 https://doi.org/10.1016/j.jff.2019.103758
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Xinyu Bai
Yeewen Chai
Wanlan Shi
Yingying Li
Tao Zhang
Ping Liu
Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
description Lonicera japonica Thunb. has been widely used as food ingredients and healthy drinks in the Asian countries, which was reported to possess some good activities. However, it remains unknown in the immunomodulation of Lonicera japonica polysaccharides (LJP) on allergic rhinitis (AR). This study aimed to investigate the impact of LJP on ovalbumin-induced AR in BALB/c mice model. LJP significantly inhibited AR symptoms and eosinophil number in nasal mucosa. Besides, the increased serum levels of IgE, TNF-α, IL-1β and IL-17 were markedly decreased when AR mice were treated with LJP. The mRNA expression levels of IL-4, IL-5, IL-6, IL-17, IL-23, ROR-γt and STAT3 in OVA group were increased, and SOCS3 was reduced, while LJP inhibited the changes. The present study indicated that LJP suppressed the inflammatory response in AR sensitized by ovalbumin, showing that LJP has the potential to treat AR through the regulation of Th17 cells.
format Article
author Xinyu Bai
Yeewen Chai
Wanlan Shi
Yingying Li
Tao Zhang
Ping Liu
author_facet Xinyu Bai
Yeewen Chai
Wanlan Shi
Yingying Li
Tao Zhang
Ping Liu
author_sort Xinyu Bai
title Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
title_short Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
title_full Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
title_fullStr Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
title_full_unstemmed Lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of Th17 cells in BALB/c mice
title_sort lonicera japonica polysaccharides attenuate ovalbumin-induced allergic rhinitis by regulation of th17 cells in balb/c mice
publisher Elsevier
publishDate 2020
url https://eprints.ums.edu.my/id/eprint/25504/1/Lonicera%20japonica%20polysaccharides%20attenuate%20ovalbumin-induced%20allergic%20rhinitis%20by%20regulation.pdf
https://eprints.ums.edu.my/id/eprint/25504/
https://doi.org/10.1016/j.jff.2019.103758
_version_ 1760230376817557504
score 13.211869

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