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Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia

Oxidative damage of biomolecules is implicated in the pathogenesis of various chronic diseases including cancer. This has led to intensive investigation aimed at reducing the extent of such oxidative injury. The present study was aimed to evaluate the total phenolics, hepatoprotective and antioxida...

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Main Author: Mohammad Iqbal
Format: Research Report
Language:English
Published: Universiti Malaysia Sabah 2011
Subjects:
SB Plant culture
Online Access:https://eprints.ums.edu.my/id/eprint/22785/1/Hepatoprotective%20mechanisms%20of%20selected%20herbal%20plants%20Native%20to%20Sabah.pdf
https://eprints.ums.edu.my/id/eprint/22785/
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spelling my.ums.eprints.227852019-07-18T13:47:08Z https://eprints.ums.edu.my/id/eprint/22785/ Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia Mohammad Iqbal SB Plant culture Oxidative damage of biomolecules is implicated in the pathogenesis of various chronic diseases including cancer. This has led to intensive investigation aimed at reducing the extent of such oxidative injury. The present study was aimed to evaluate the total phenolics, hepatoprotective and antioxidative effects of eighteen (18) selected herbal plants viz. Andrographis paniculata; Plantago major; Orthosiphon stamineus; Peperomia pellucida; Centella asiatica; Strobilanthes crispus; Eleusine indica; Thysanolaena latifolia; Merremia bornensis; Hoya corona ria; Homalanthus species; Momordica charantia; Parkia speciosa; Catharantus roseus; Pereskia sacharosa; Lantana camara; Oxalis corniculata; Cymbopongon citratus, known to be used as medicinal plants by local ethnic communities in Sabah, against carbon tetrachloride (CCI4) mediated oxidative tissue damage and toxicity in rats. Animals were pre-treated with selected herbal plants accordingly to the selected doses (100 to 300 mg/kg b.w.) for 14 days prior to the administration of (C14 (1.2 ml/kg b.w. p.o) on 13th and 14th days. All of these animals were sacrificed 24 hours after the last dose of (C14 or saline. Blood and liver tissues were taken quickly for biochemical and histopathological studies to assess the derangement in the functioning of liver. Hepatic damage was evaluated by employing serum biochemical parameters (alanine aminotransferase-ALT, aspartate aminotransferase-AST and lactate dehydrogenase-LDH), malondialdehye (MDA) level, reduced GSH and antioxidant enzymes (catalase-CAT, glutathione peroxidase-GPX, quinone reductaseQR, glutathione S-transferase-GST, glutathione reductase-GR and glucose-6-phosphate dehyrogenase-G6PD). In addition, CCI4 mediated hepatic damage was further evaluated by histopathological examination. However, most of these changes were alleviated by prophylactic treatment of animals with selected herbal plants dose dependently (p<O.OS).The protection was further evident through decreased histopathological alterations in liver. Selected herbal plants were also evaluated for total phenolic content and 2,2-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. The results of present study indicated that the hepatoprotective effects of selected herbal plant extract might be ascribable to its antioxidant and free radical scavenging properties. We concluded that only twelve (12) selected herbal plants viz. Andrographis paniculata; Orthosiphon stamineus; Centella asiatica; Strobilanthes crispus; Eleusine indica; Thysanolaena latifolia; Merremia bornensis; Hoya coronaria; Homalanthus species; Momordica charantia; Parkia speciosa; Cymbopongon citratus, could be used as hepatoprotective agents and possess the potential to be used to treat or prevent degenerative diseases where oxidative stress is implicated. However, other six (6) selected herbal plants viz. Plantago major; Peperomia pellucida; Catharantus roseus: Pereskia sacha rosa; Lantana camara; Oxalis corniculata, has no effect on (CI4-mediated oxidative tissue damage and toxicity in rats. Prior to considering the therapeutic aspects of selected herbal plants, the mechanism of action, comprehension investigation of pharmacokinetic and bioavailability of its bioactive constituents are much essential and needed. Universiti Malaysia Sabah 2011 Research Report NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/22785/1/Hepatoprotective%20mechanisms%20of%20selected%20herbal%20plants%20Native%20to%20Sabah.pdf Mohammad Iqbal (2011) Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia. (Unpublished)
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic SB Plant culture
spellingShingle SB Plant culture
Mohammad Iqbal
Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
description Oxidative damage of biomolecules is implicated in the pathogenesis of various chronic diseases including cancer. This has led to intensive investigation aimed at reducing the extent of such oxidative injury. The present study was aimed to evaluate the total phenolics, hepatoprotective and antioxidative effects of eighteen (18) selected herbal plants viz. Andrographis paniculata; Plantago major; Orthosiphon stamineus; Peperomia pellucida; Centella asiatica; Strobilanthes crispus; Eleusine indica; Thysanolaena latifolia; Merremia bornensis; Hoya corona ria; Homalanthus species; Momordica charantia; Parkia speciosa; Catharantus roseus; Pereskia sacharosa; Lantana camara; Oxalis corniculata; Cymbopongon citratus, known to be used as medicinal plants by local ethnic communities in Sabah, against carbon tetrachloride (CCI4) mediated oxidative tissue damage and toxicity in rats. Animals were pre-treated with selected herbal plants accordingly to the selected doses (100 to 300 mg/kg b.w.) for 14 days prior to the administration of (C14 (1.2 ml/kg b.w. p.o) on 13th and 14th days. All of these animals were sacrificed 24 hours after the last dose of (C14 or saline. Blood and liver tissues were taken quickly for biochemical and histopathological studies to assess the derangement in the functioning of liver. Hepatic damage was evaluated by employing serum biochemical parameters (alanine aminotransferase-ALT, aspartate aminotransferase-AST and lactate dehydrogenase-LDH), malondialdehye (MDA) level, reduced GSH and antioxidant enzymes (catalase-CAT, glutathione peroxidase-GPX, quinone reductaseQR, glutathione S-transferase-GST, glutathione reductase-GR and glucose-6-phosphate dehyrogenase-G6PD). In addition, CCI4 mediated hepatic damage was further evaluated by histopathological examination. However, most of these changes were alleviated by prophylactic treatment of animals with selected herbal plants dose dependently (p<O.OS).The protection was further evident through decreased histopathological alterations in liver. Selected herbal plants were also evaluated for total phenolic content and 2,2-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. The results of present study indicated that the hepatoprotective effects of selected herbal plant extract might be ascribable to its antioxidant and free radical scavenging properties. We concluded that only twelve (12) selected herbal plants viz. Andrographis paniculata; Orthosiphon stamineus; Centella asiatica; Strobilanthes crispus; Eleusine indica; Thysanolaena latifolia; Merremia bornensis; Hoya coronaria; Homalanthus species; Momordica charantia; Parkia speciosa; Cymbopongon citratus, could be used as hepatoprotective agents and possess the potential to be used to treat or prevent degenerative diseases where oxidative stress is implicated. However, other six (6) selected herbal plants viz. Plantago major; Peperomia pellucida; Catharantus roseus: Pereskia sacha rosa; Lantana camara; Oxalis corniculata, has no effect on (CI4-mediated oxidative tissue damage and toxicity in rats. Prior to considering the therapeutic aspects of selected herbal plants, the mechanism of action, comprehension investigation of pharmacokinetic and bioavailability of its bioactive constituents are much essential and needed.
format Research Report
author Mohammad Iqbal
author_facet Mohammad Iqbal
author_sort Mohammad Iqbal
title Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
title_short Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
title_full Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
title_fullStr Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
title_full_unstemmed Hepatoprotective mechanisms of selected herbal plants Native to Sabah, Malaysia
title_sort hepatoprotective mechanisms of selected herbal plants native to sabah, malaysia
publisher Universiti Malaysia Sabah
publishDate 2011
url https://eprints.ums.edu.my/id/eprint/22785/1/Hepatoprotective%20mechanisms%20of%20selected%20herbal%20plants%20Native%20to%20Sabah.pdf
https://eprints.ums.edu.my/id/eprint/22785/
_version_ 1760230016152502272
score 13.211869

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