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The Advancement of Biomaterials in Regulating Stem Cell Fate.

Stem cells are well-known to have prominent roles in tissue engineering applications. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate into every cell type in the body while adult stem cells such as mesenchymal stem cells (MSCs) can be isolated from various so...

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Main Authors: Vun Vun Hiew, Siti Fatimah Simat, Peik Lin Teoh
Format: Article
Language:English
Published: 2018
Online Access:https://eprints.ums.edu.my/id/eprint/22260/1/The%20Advancement%20of%20Biomaterials%20in%20Regulating%20Stem%20Cell%20Fate.pdf
https://eprints.ums.edu.my/id/eprint/22260/
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spelling my.ums.eprints.222602019-06-18T08:23:11Z https://eprints.ums.edu.my/id/eprint/22260/ The Advancement of Biomaterials in Regulating Stem Cell Fate. Vun Vun Hiew Siti Fatimah Simat Peik Lin Teoh Stem cells are well-known to have prominent roles in tissue engineering applications. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate into every cell type in the body while adult stem cells such as mesenchymal stem cells (MSCs) can be isolated from various sources. Nevertheless, an utmost limitation in harnessing stem cells for tissue engineering is the supply of cells. The advances in biomaterial technology allows the establishment of ex vivo expansion systems to overcome this bottleneck. The progress of various scaffold fabrication could direct stem cell fate decisions including cell proliferation and differentiation into specific lineages in vitro. Stem cell biology and biomaterial technology promote synergistic effect on stem cell-based regenerative therapies. Therefore, understanding the interaction of stem cell and biomaterials would allow the designation of new biomaterials for future clinical therapeutic applications for tissue regeneration. This review focuses mainly on the advances of natural and synthetic biomaterials in regulating stem cell fate decisions. We have also briefly discussed how biological and biophysical properties of biomaterials including wettability, chemical functionality, biodegradability and stiffness play their roles. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/22260/1/The%20Advancement%20of%20Biomaterials%20in%20Regulating%20Stem%20Cell%20Fate.pdf Vun Vun Hiew and Siti Fatimah Simat and Peik Lin Teoh (2018) The Advancement of Biomaterials in Regulating Stem Cell Fate. Stem Cells Reviews and Reports, 14 (1). pp. 43-57. doi: 10.1007/s12015-017-9764-y.
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
description Stem cells are well-known to have prominent roles in tissue engineering applications. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate into every cell type in the body while adult stem cells such as mesenchymal stem cells (MSCs) can be isolated from various sources. Nevertheless, an utmost limitation in harnessing stem cells for tissue engineering is the supply of cells. The advances in biomaterial technology allows the establishment of ex vivo expansion systems to overcome this bottleneck. The progress of various scaffold fabrication could direct stem cell fate decisions including cell proliferation and differentiation into specific lineages in vitro. Stem cell biology and biomaterial technology promote synergistic effect on stem cell-based regenerative therapies. Therefore, understanding the interaction of stem cell and biomaterials would allow the designation of new biomaterials for future clinical therapeutic applications for tissue regeneration. This review focuses mainly on the advances of natural and synthetic biomaterials in regulating stem cell fate decisions. We have also briefly discussed how biological and biophysical properties of biomaterials including wettability, chemical functionality, biodegradability and stiffness play their roles.
format Article
author Vun Vun Hiew
Siti Fatimah Simat
Peik Lin Teoh
spellingShingle Vun Vun Hiew
Siti Fatimah Simat
Peik Lin Teoh
The Advancement of Biomaterials in Regulating Stem Cell Fate.
author_facet Vun Vun Hiew
Siti Fatimah Simat
Peik Lin Teoh
author_sort Vun Vun Hiew
title The Advancement of Biomaterials in Regulating Stem Cell Fate.
title_short The Advancement of Biomaterials in Regulating Stem Cell Fate.
title_full The Advancement of Biomaterials in Regulating Stem Cell Fate.
title_fullStr The Advancement of Biomaterials in Regulating Stem Cell Fate.
title_full_unstemmed The Advancement of Biomaterials in Regulating Stem Cell Fate.
title_sort advancement of biomaterials in regulating stem cell fate.
publishDate 2018
url https://eprints.ums.edu.my/id/eprint/22260/1/The%20Advancement%20of%20Biomaterials%20in%20Regulating%20Stem%20Cell%20Fate.pdf
https://eprints.ums.edu.my/id/eprint/22260/
_version_ 1760229945477431296
score 13.211869

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